Research progress on dendritic cell vaccines in cancer immunotherapy

The subtle interplay between gamma delta T lymphocytes and dendritic cells: is there a role for a therapeutic cancer vaccine in the era of combinatorial strategies?

(2021) Domenico Galati et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Novel targeted therapies of T cell lymphomas

(2021) Katarzyna Iżykowska et al.   Journal of Hematology & Oncology

Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model

(2021) Dina Stroopinsky et al.   HAEMATOLOGICA

The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1

(2021) Ming Yi et al.   Journal of Hematology & Oncology

Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy

(2021) Hye-Ran Kim et al.   Journal of Hematology & Oncology

Next generation of immune checkpoint inhibitors and beyond

(2021) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

Bispecific T cell engagers: an emerging therapy for management of hematologic malignancies

(2021) Zheng Tian et al.   Journal of Hematology & Oncology

The efficacy of dendritic cell vaccine for newly diagnosed glioblastoma: a meta-analysis of randomized controlled studies

(2021) Zhongtao Liu et al.   NEUROCHIRURGIE

A new PD-1-specific nanobody enhances the antitumor activity of T-cells in synergy with dendritic cell vaccine

(2021) Wei Shi et al.   CANCER LETTERS

Combine and conquer: manganese synergizing anti-TGF-β/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers

(2021) Ming Yi et al.   Journal of Hematology & Oncology

Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target

(2021) Wenjing Qian et al.   Journal of Hematology & Oncology

Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities

(2021) Yingyue Liu et al.   Journal of Hematology & Oncology

A phase I/II feasibility vaccine study by autologous leukemic apoptotic corpse-pulsed dendritic cells for elderly AML patients

(2021) Patrice Chevallier et al.   Human Vaccines & Immunotherapeutics

Recent Advances in Experimental Dendritic Cell Vaccines for Cancer

(2021) Ivan Y. Filin et al.   Frontiers in Oncology

The Efficacy of Dendritic Cell Vaccine for Newly Diagnosed Glioblastoma: A Meta-analysis of Randomized Controlled Studies

(2021) Long Tan et al.   CLINICAL NEUROPHARMACOLOGY

Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials

(2021) Joline Ingels et al.   CYTOTHERAPY

Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers

(2021) Yiyin Zhang et al.   Journal of Hematology & Oncology

Targeting CD47 for cancer immunotherapy

(2021) Zhongxing Jiang et al.   Journal of Hematology & Oncology

Combination strategies to maximize the benefits of cancer immunotherapy

(2021) Shaoming Zhu et al.   Journal of Hematology & Oncology

Feasibility of using monocyte-derived dendritic cells obtained from cryopreserved cells for DC-based vaccines

(2021) Lorena Usero et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Long‐term first‐in‐man Phase I/II study of an adjuvant dendritic cell vaccine in patients with high‐risk prostate cancer after radical prostatectomy

(2021) Anne M. A. Tryggestad et al.   PROSTATE

Dendritic Cell Vaccination of Glioblastoma: Road to Success or Dead End

(2021) Angeliki Datsi et al.   Frontiers in Immunology

Tumor-associated antigen-based personalized dendritic cell vaccine in solid tumor patients

(2020) Qian-Ting Wang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial

(2020) Steve Boudewijns et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Advances in the Treatment of Acute Myeloid Leukemia: New Drugs and New Challenges

(2020) Nicholas J. Short et al.   Cancer Discovery

Therapeutic Cancer Vaccination with Ex Vivo RNA-Transfected Dendritic Cells—An Update

(2020) Jan Dörrie et al.   Pharmaceutics

Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy

(2020) Chongxian Pan et al.   Journal of Hematology & Oncology

Whole leukemia cell vaccines: Past progress and future directions

(2020) Young Sok Ji et al.   VACCINE

A randomized controlled phase II clinical trial on mRNA electroporated autologous monocyte-derived dendritic cells (TriMixDC-MEL) as adjuvant treatment for stage III/IV melanoma patients who are disease-free following the resection of macrometastases

(2020) Yanina Jansen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Intranodal Administration of Neoantigen Peptide-loaded Dendritic Cell Vaccine Elicits Epitope-specific T Cell Responses and Clinical Effects in a Patient with Chemorefractory Ovarian Cancer with Malignant Ascites

(2020) Takashi Morisaki et al.   IMMUNOLOGICAL INVESTIGATIONS

WT1, PRAME, and PR3 mRNA Expression in Acute Myeloid Leukemia (AML)

(2020) Brigitte Steger et al.   JOURNAL OF IMMUNOTHERAPY

Antitumour dendritic cell vaccination in a priming and boosting approach

(2020) Alexandre Harari et al.   NATURE REVIEWS DRUG DISCOVERY

Overcoming T cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH

(2020) Amel Sengal et al.   BLOOD

Dendritic cell biology and its role in tumor immunotherapy

(2020) Yingying Wang et al.   Journal of Hematology & Oncology

Myelodysplastic Syndromes

(2020) Mario Cazzola   NEW ENGLAND JOURNAL OF MEDICINE

Dysregulated NF-κB–Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma

(2020) Deena M. Maurer et al.   Cancer Immunology Research

Effects of decitabine on allogeneic immune reactions of donor lymphocyte infusion via activation of dendritic cells

(2020) Yong-Rim Kwon et al.   Experimental Hematology & Oncology

Pharmacological combination of nivolumab with dendritic cell vaccines in cancer immunotherapy: An overview

(2020) João Calmeiro et al.   PHARMACOLOGICAL RESEARCH

Exosomes in the serum of Acute Myeloid Leukemia patients induce dendritic cell tolerance: Implications for immunotherapy

(2019) Bruno Deltreggia Benites et al.   VACCINE

Hypomethylating agent alters the immune microenvironment in acute myeloid leukaemia (AML) and enhances the immunogenicity of a dendritic cell/AML vaccine

(2019) Myrna R. Nahas et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting Immune Signaling Checkpoints in Acute Myeloid Leukemia

(2019) Krzysztof Giannopoulos   Journal of Clinical Medicine

Dendritic Cell-Based Immunotherapy of Acute Myeloid Leukemia

(2019) Heleen H. Van Acker et al.   Journal of Clinical Medicine

Clinical and Antitumor Immune Responses in Relapsed/Refractory Follicular Lymphoma Patients after Intranodal Injections of IFNα-Dendritic Cells and Rituximab

(2019) M. Christina Cox et al.   CLINICAL CANCER RESEARCH

Role of Interferon (IFN)α in “Cocktails” for the Generation of (Leukemia-derived) Dendritic Cells (DCleu) From Blasts in Blood From Patients (pts) With Acute Myeloid Leukemia (AML) and the Induction of Antileukemic Reactions

(2019) Annika Hirn Lopez et al.   JOURNAL OF IMMUNOTHERAPY

CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential

(2019) Ziduo Li et al.   Frontiers in Immunology

Can Dendritic Cell Vaccination Prevent Leukemia Relapse?

(2019) Liam J. O’Brien et al.   Cancers

PGE1-Containing Protocols Generate Mature (Leukemia-Derived) Dendritic Cells Directly from Leukemic Whole Blood

(2019) Daniel Christoph Amberger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tolerogenic dendritic cell-based treatment for multiple sclerosis (MS): a harmonised study protocol for two phase I clinical trials comparing intradermal and intranodal cell administration

(2019) Barbara Willekens et al.   BMJ Open

Lenalidomide improves the therapeutic effect of an interferon-α-dendritic cell-based lymphoma vaccine

(2019) Caterina Lapenta et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Delivery strategies of cancer immunotherapy: recent advances and future perspectives

(2019) Zhongwei Zhao et al.   Journal of Hematology & Oncology

Dendritic Cell Vaccination in Metastatic Melanoma Turns “Non-T Cell Inflamed” Into “T-Cell Inflamed” Tumors

(2019) Jenny Bulgarelli et al.   Frontiers in Immunology

Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients

(2018) M E Rodríguez-Ruiz et al.   ANNALS OF ONCOLOGY

Phase I trial of Lipovaxin-MM, a novel dendritic cell-targeted liposomal vaccine for malignant melanoma

(2018) Tessa Gargett et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

(2018) Linda M. Liau et al.   Journal of Translational Medicine

Interleukin-15-Cultured Dendritic Cells Enhance Anti-Tumor Gamma Delta T Cell Functions through IL-15 Secretion

(2018) Heleen H. Van Acker et al.   Frontiers in Immunology

Dendritic Cells and Programmed Death-1 Blockade: A Joint Venture to Combat Cancer

(2018) Maarten Versteven et al.   Frontiers in Immunology

A novel allogeneic off-the-shelf dendritic cell vaccine for post-remission treatment of elderly patients with acute myeloid leukemia

(2018) Arjan A. van de Loosdrecht et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Randomized-controlled phase II trial of salvage chemotherapy after immunization with a TP53-transfected dendritic cell-based vaccine (Ad.p53-DC) in patients with recurrent small cell lung cancer

(2018) Alberto A. Chiappori et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Next-generation dendritic cell-based vaccines for leukemia patients

(2017) Jean-Marc Hoffmann et al.   Immunotherapy

Recent developments in immunotherapy of acute myeloid leukemia

(2017) Felix S. Lichtenegger et al.   Journal of Hematology & Oncology

Intravenous dendritic cell administration enhances suppression of lung metastasis induced by carbon-ion irradiation

(2017) Ken Ando et al.   JOURNAL OF RADIATION RESEARCH

Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape

(2017) Abhishek D. Garg et al.   TRENDS IN IMMUNOLOGY

Desirable cytolytic immune effector cell recruitment by interleukin-15 dendritic cells

(2017) Heleen H. Van Acker et al.   Oncotarget

Induction of Immune Response after Allogeneic Wilms' Tumor 1 Dendritic Cell Vaccination and Donor Lymphocyte Infusion in Patients with Hematologic Malignancies and Post-Transplantation Relapse

(2016) Nirali N. Shah et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Dendritic cell-based immunotherapy

(2016) Rachel L Sabado et al.   CELL RESEARCH

Functions of Murine Dendritic Cells

(2016) Vivek Durai et al.   IMMUNITY

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

(2016) Martin Guilliams et al.   IMMUNITY

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting PD-1 and Tim-3 Pathways to Reverse CD8 T-Cell Exhaustion and Enhance Ex Vivo T-Cell Responses to Autologous Dendritic/Tumor Vaccines

(2016) Jingwei Liu et al.   JOURNAL OF IMMUNOTHERAPY

Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions

(2016) J. Rosenblatt et al.   Science Translational Medicine

Human blood myeloid and plasmacytoid dendritic cells cross activate each other and synergize in inducing NK cell cytotoxicity

(2016) Jasper J. P. van Beek et al.   OncoImmunology

WT1 vaccination in AML and MDS: A pilot trial with synthetic analog peptides

(2015) Jason Brayer et al.   AMERICAN JOURNAL OF HEMATOLOGY

Cytokine Release Patterns in Mixed Lymphocyte Culture (MLC) of T-Cells with Dendritic Cells (DC) Generated from AML Blasts Contribute to Predict anti-Leukaemic T-Cell Reactions and Patients’ Response to Immunotherapy

(2015) Dorothea Fischbacher et al.   CELL COMMUNICATION AND ADHESION

Long-term follow-up of the AML97 study for patients aged 60 years and above with acute myeloid leukaemia: a study of the East German Haematology and Oncology Study Group (OSHO)

(2015) C. Kahl et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Tumor-Infiltrating Dendritic Cells in Cancer Pathogenesis

(2015) Jo Marie Tran Janco et al.   JOURNAL OF IMMUNOLOGY

G-CSF and GM-CSF in Neutropenia

(2015) Hrishikesh M. Mehta et al.   JOURNAL OF IMMUNOLOGY

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

(2015) David L. Porter et al.   Science Translational Medicine

Review of the Results of WT1 Peptide Vaccination Strategies for Myelodysplastic Syndromes and Acute Myeloid Leukemia from Nine Different Studies

(2015) Antonio Di Stasi et al.   Frontiers in Immunology

Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner

(2015) Sébastien Anguille et al.   PLoS One

Clinical trials of dendritic cell-based cancer vaccines in hematologic malignancies

(2015) Athalia R Pyzer et al.   Human Vaccines & Immunotherapeutics

New generation dendritic cell vaccine for immunotherapy of acute myeloid leukemia

(2014) Marion Subklewe et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dendritic cell vaccination in acute myeloid leukemia

(2014) Sébastien Anguille et al.   CYTOTHERAPY

Dendritic cell vaccine against leukemia: advances and perspectives

(2014) Dige Andom Tesfatsion   Immunotherapy

Profiles of Activation, Differentiation–Markers, or β-Integrins on T Cells Contribute to Predict T Cells’ Antileukemic Responses After Stimulation With Leukemia-derived Dendritic Cells

(2014) Valentin Vogt et al.   JOURNAL OF IMMUNOTHERAPY

Clinical use of dendritic cells for cancer therapy

(2014) Sébastien Anguille et al.   LANCET ONCOLOGY

The targeting of immunosuppressive mechanisms in hematological malignancies

(2014) M H Andersen   LEUKEMIA

Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets

(2014) Florian Wimmers et al.   Frontiers in Immunology

Reduced intensity allogeneic hematopoietic transplantation is an established standard of care for treatment of older patients with acute myeloid leukemia

(2013) Richard Champlin   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

MUC1 Is a Potential Target for the Treatment of Acute Myeloid Leukemia Stem Cells

(2013) D. Stroopinsky et al.   CANCER RESEARCH

Antileukemic T-cell Responses Can Be Predicted by the Composition of Specific Regulatory T-cell Subpopulations

(2013) Julia Schick et al.   JOURNAL OF IMMUNOTHERAPY

Autologous Dendritic Cells Combined with Cytokine-Induced Killer Cells Synergize Low-Dose Chemotherapy in Elderly Patients with Acute Myeloid Leukaemia

(2013) M Dong et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Langerhans-type and monocyte-derived human dendritic cells have different susceptibilities to mRNA electroporation with distinct effects on maturation and activation: implications for immunogenicity in dendritic cell-based immunotherapy

(2013) David J Chung et al.   Journal of Translational Medicine

In vitro induction of potent tumor-specific cytotoxic T lymphocytes using TLR agonist-activated AML-DC

(2013) Maryam Nourizadeh et al.   Targeted Oncology

Dendritic Cell-Based Immunotherapy for Myeloid Leukemias

(2013) Christian M. Schürch et al.   Frontiers in Immunology

Deciphering the Message Broadcast by Tumor-Infiltrating Dendritic Cells

(2012) Nina Karthaus et al.   AMERICAN JOURNAL OF PATHOLOGY

Gene Immunotherapy of Chronic Lymphocytic Leukemia: A Phase I Study of Intranodally Injected Adenovirus Expressing a Chimeric CD154 Molecule

(2012) J. E. Castro et al.   CANCER RESEARCH

In vitro-induced response patterns of antileukemic T cells: characterization by spectratyping and immunophenotyping

(2012) Susanne Reuther et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Combined immunophenotyping and fluorescencein situhybridization with chromosome-specific DNA probes allows quantification and differentiation ofex vivogenerated dendritic cells, leukemia-derived dendritic cells and clonal leukemic cells in patients with acute myeloid leukemia

(2012) Andreas Kremser et al.   LEUKEMIA & LYMPHOMA

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-15-Induced CD56+ Myeloid Dendritic Cells Combine Potent Tumor Antigen Presentation with Direct Tumoricidal Potential

(2012) Sébastien Anguille et al.   PLoS One

A phase I/IIa clinical trial of immunotherapy for elderly patients with acute myeloid leukaemia using dendritic cells co-pulsed with WT1 peptide and zoledronate

(2011) Toshio Kitawaki et al.   BRITISH JOURNAL OF HAEMATOLOGY

Vaccination with dendritic cells loaded with tumor apoptotic bodies (Apo-DC) in patients with chronic lymphocytic leukemia: effects of various adjuvants and definition of immune response criteria

(2011) Marzia Palma et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Various ‘dendritic cell antigens’ are already expressed on uncultured blasts in acute myeloid leukemia and myelodysplastic syndromes

(2011) Julia Dreyssig et al.   Immunotherapy

High-dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma

(2010) J. Greiner et al.   HAEMATOLOGICA

Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells

(2010) A. Curti et al.   HAEMATOLOGICA

The Quality and Quantity of Leukemia-derived Dendritic Cells From Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome Are a Predictive Factor for the Lytic Potential of Dendritic Cells-primed Leukemia-Specific T Cells

(2010) Christine Grabrucker et al.   JOURNAL OF IMMUNOTHERAPY

Dendritic Cells (DCs) Can Be Successfully Generated From Leukemic Blasts in Individual Patients With AML or MDS

(2010) Andreas Kremser et al.   JOURNAL OF IMMUNOTHERAPY

The DNA demethylating agent 5-aza-2′-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells

(2010) Maika Almstedt et al.   LEUKEMIA RESEARCH

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

(2010) V. F. Van Tendeloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole tumor antigen vaccines

(2010) Cheryl Lai-Lai Chiang et al.   SEMINARS IN IMMUNOLOGY

A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS

(2009) U. Keilholz et al.   BLOOD

In situ Expression of Tumor Antigens by Messenger RNA-Electroporated Dendritic Cells in Lymph Nodes of Melanoma Patients

(2009) D. H. Schuurhuis et al.   CANCER RESEARCH

Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties

(2009) Sébastien Anguille et al.   Journal of Translational Medicine

Chronic lymphocytic leukemia (CLL) cells genetically modified to express B7-1, ICAM-1, and LFA-3 confer APC capacity to T cells from CLL patients

(2008) Mary T. Litzinger et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Clinical Grade OK432-activated Dendritic Cells

(2008) Emma West et al.   JOURNAL OF IMMUNOTHERAPY