Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201

Overview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE2?

(2021) Gopa Mahesh et al.   Journal of Inflammation Research

Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators

(2021) Simona Pace et al.   PHARMACOLOGICAL RESEARCH

From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

(2021) Tran Thi Van Anh et al.   Acta Pharmaceutica Sinica B

Beneficial Modulation of Lipid Mediator Biosynthesis in Innate Immune Cells by Antirheumatic Tripterygium wilfordii Glycosides

(2021) Kehong Zhang et al.   Biomolecules

Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators

(2021) Nathaniel C. Gilbert et al.   BIOCHEMICAL PHARMACOLOGY

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

(2020) Nathaniel C. Gilbert et al.   Nature Chemical Biology

Specialized pro-resolving mediator network: an update on production and actions

(2020) Nan Chiang et al.   Essays in Biochemistry

Eicosanoids

(2020) Philip C. Calder   Essays in Biochemistry

Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution

(2020) Paul M. Jordan et al.   Cell Reports

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

(2019) Markus Werner et al.   FASEB JOURNAL

Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy

(2019) Jana Gerstmeier et al.   BIOCHEMICAL PHARMACOLOGY

Selectivity of phospholipid hydrolysis by phospholipase A 2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization

(2018) Alma M. Astudillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Natural products as inhibitors of prostaglandin E 2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis

(2018) Andreas Koeberle et al.   BIOTECHNOLOGY ADVANCES

Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis

(2018) Zehra Tuğçe Gür et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of multi-target inhibitors of leukotriene and prostaglandin E 2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7

(2018) Zehra Tuğçe Gür et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukotriene biosynthetic enzymes as therapeutic targets

(2018) Jesper Z. Haeggström   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanism of 15-lipoxygenase allosteric activation and inhibition

(2018) Hu Meng et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation

(2018) Sun-Yee Cheung et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs

(2018) Hartmut Kuhn et al.   PROGRESS IN LIPID RESEARCH

Two-pronged approach to anti-inflammatory therapy through the modulation of the arachidonic acid cascade

(2018) Angelo Sala et al.   BIOCHEMICAL PHARMACOLOGY

Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents

(2017) Oliver Werz et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Does promoting resolution instead of inhibiting inflammation represent the new paradigm in treating infections?

(2017) Jesmond Dalli   MOLECULAR ASPECTS OF MEDICINE

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes

(2016) Jana Gerstmeier et al.   FASEB JOURNAL

Cyclooxygenase inhibitors: From pharmacology to clinical read-outs

(2015) Paola Patrignani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

(2015) Olof Rådmark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Recent advances for FLAP inhibitors

(2015) Daniel Pettersen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

(2015) Christoph Lehmann et al.   FASEB JOURNAL

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

(2015) Igor Ivanov et al.   GENE

Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution

(2015) Hu Meng et al.   JOURNAL OF MEDICINAL CHEMISTRY

An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis

(2014) Jana Gerstmeier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network

(2012) Chong He et al.   Molecular BioSystems

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

(2011) William L. Smith et al.   CHEMICAL REVIEWS