Overview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE2?
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Title
Overview on the Discovery and Development of Anti-Inflammatory Drugs: Should the Focus Be on Synthesis or Degradation of PGE2?
Authors
Keywords
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Journal
Journal of Inflammation Research
Volume Volume 14, Issue -, Pages 253-263
Publisher
Informa UK Limited
Online
2021-02-03
DOI
10.2147/jir.s278514
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Note: Only part of the references are listed.- Pharmacologic Blockade of 15-PGDH Protects Against Acute Renal Injury Induced by LPS in Mice
- (2020) Shuying Miao et al. Frontiers in Physiology
- DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1
- (2020) Shuo Zhou et al. Scientific Reports
- Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis
- (2020) Julianne N. P. Smith et al. Scientific Reports
- miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer
- (2019) Nicholas J. Monteleone et al. Scientific Reports
- Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
- (2019) Filip Bergqvist et al. Frontiers in Pharmacology
- A review on mPGES-1 inhibitors: From preclinical studies to clinical applications
- (2019) Filip Bergqvist et al. PROSTAGLANDINS & OTHER LIPID MEDIATORS
- Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach
- (2018) Jaismy Jacob P et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Role of dihydroartemisinin in regulating prostaglandin E2 synthesis cascade and inflammation in endothelial cells
- (2018) Jie Yin et al. HEART AND VESSELS
- Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs
- (2018) Kai Ding et al. Scientific Reports
- Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth
- (2018) Anna Kock et al. EBioMedicine
- Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas
- (2018) Kota Arima et al. ONCOGENE
- Diclofenac use and cardiovascular risks: series of nationwide cohort studies
- (2018) Morten Schmidt et al. BMJ-British Medical Journal
- Evaluation of anti-inflammatory and immunomodulatory effects of Premna integrifolia extracts and assay-guided isolation of a COX-2/5-LOX dual inhibitor
- (2018) Rajaram Azad et al. FITOTERAPIA
- MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma
- (2018) Young Soo Park et al. Scientific Reports
- Fluoride Induces Neuroinflammation and Alters Wnt Signaling Pathway in BV2 Microglial Cells
- (2017) Rui Chen et al. INFLAMMATION
- Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair
- (2017) Monika I. Antczak et al. JOURNAL OF MEDICINAL CHEMISTRY
- In-vitro wound healing effect of 15-hydroxyprostaglandin dehydrogenase inhibitor from plant
- (2017) Sandeep Karna Pharmacognosy Magazine
- Prostaglandin terminal synthases as novel therapeutic targets
- (2017) Shuntaro HARA PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Increased expression of tight junction protein�occludin is associated with the protective effect of mosapride against aspirin‑induced gastric injury
- (2017) Chenchen Liu et al. Experimental and Therapeutic Medicine
- 15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury
- (2017) Lu Yao et al. PLoS One
- Cardiovascular effects of cyclooxygenase-2 inhibitors: a mechanistic and clinical perspective
- (2016) Carlo Patrono BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug–Induced Small Bowel Injury: A Randomized, Placebo-Controlled Trial
- (2016) Ema Washio et al. Clinical Gastroenterology and Hepatology
- Curcumin Blocks Naproxen-Induced Gastric Antral Ulcerations through Inhibition of Lipid Peroxidation and Activation of Enzymatic Scavengers in Rats
- (2016) Jeong-Hwan Kim et al. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders
- (2015) Andreas Koeberle et al. BIOCHEMICAL PHARMACOLOGY
- The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages
- (2015) Tomasz Olszowski et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?
- (2015) G O'Callaghan et al. BRITISH JOURNAL OF PHARMACOLOGY
- 15-Hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes
- (2015) HAK-JAE KIM et al. Molecular Medicine Reports
- Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways
- (2015) Nicholas S. Kirkby et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclooxygenase-1 as the Main Source of Proinflammatory Factors After Sodium Orthovanadate Treatment
- (2014) Jan Korbecki et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- Cardiovascular Risk with Non-steroidal Anti-inflammatory Drugs: Clinical Implications
- (2014) Alfonso E. Bello et al. DRUG SAFETY
- Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system
- (2014) Zhihua Yue et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Multifaceted roles of PGE2 in inflammation and cancer
- (2012) Masako Nakanishi et al. Seminars in Immunopathology
- Fluoride in low concentration modifies expression and activity of 15 lipoxygenase in human PBMC differentiated monocyte/macrophage
- (2012) I. Gutowska et al. TOXICOLOGY
- Inibição seletiva da ciclo-oxigenase-2: riscos e benefícios
- (2012) Reila Tainá Mendes et al. Revista Brasileira De Reumatologia
- Identification and development of mPGES-1 inhibitors: where we are at?
- (2011) Hui-Hua Chang et al. Future Medicinal Chemistry
- mPGES-1 as a target for cancer suppression
- (2010) Masako Nakanishi et al. BIOCHIMIE
- Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report
- (2009) Marco Zaffanello et al. ACTA PAEDIATRICA
- Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages
- (2009) D. Bharat Reddy et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment
- (2009) A. Greenhough et al. CARCINOGENESIS
- Eicosanoids in inflammation and cancer: the role of COX-2
- (2009) Smita Agarwal et al. Expert Review of Clinical Immunology
- Prostaglandin E2 at new glance: Novel insights in functional diversity offer therapeutic chances
- (2009) Daniel F. Legler et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Chebulagic acid, a COX–LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., induces apoptosis in COLO-205 cell line
- (2009) D. Bharat Reddy et al. JOURNAL OF ETHNOPHARMACOLOGY
- Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation
- (2008) Takao Shimizu Annual Review of Pharmacology and Toxicology
- Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1
- (2008) A. Koeberle et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
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