Molecular mechanism of 15-lipoxygenase allosteric activation and inhibition

Dynamically Driven Protein Allostery Exhibits Disparate Responses for Fast and Slow Motions

(2015) Jingjing Guo et al.   BIOPHYSICAL JOURNAL

Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution

(2015) Hu Meng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two Pathways Mediate Interdomain Allosteric Regulation in Pin1

(2015) Jingjing Guo et al.   STRUCTURE

Dynamics-Driven Allostery in Protein Kinases

(2015) Alexandr P. Kornev et al.   TRENDS IN BIOCHEMICAL SCIENCES

Systems Biology Brings New Dimensions for Structure-Based Drug Design

(2014) Jianfeng Pei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential simulated annealing: a robust and efficient global optimization algorithm for parameter estimation of biological networks

(2014) Ziwei Dai et al.   Molecular BioSystems

Binding Site Detection and Druggability Prediction of Protein Targets for Structure- Based Drug Design

(2013) Yaxia Yuan et al.   CURRENT PHARMACEUTICAL DESIGN

15-Lipoxygenases in cancer: A double-edged sword?

(2013) Adi J. Klil-Drori et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

LigBuilder 2: A Practicalde NovoDrug Design Approach

(2011) Yaxia Yuan et al.   Journal of Chemical Information and Modeling

Discovery and Biological Evaluation of a Novel Class of Dual Microsomal Prostaglandin E2Synthase-1/5-lipoxygenase Inhibitors Based on 2-[(4,6-Diphenethoxypyrimidin-2-yl)thio]hexanoic Acid

(2011) Martina Hieke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: A key to allosteric behavior of this class of enzymes?

(2011) Igor Ivanov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

Dynamical networks in tRNA:protein complexes

(2009) A. Sethi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isotope Sensitive Branching and Kinetic Isotope Effects in the Reaction of Deuterated Arachidonic Acids with Human 12- and 15-Lipoxygenases†

(2008) Cyril Jacquot et al.   BIOCHEMISTRY

Do Human Lipoxygenases have a PDZ Regulatory Domain?

(2008) Jerzy Jankun et al.   CURRENT MOLECULAR MEDICINE