Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network

Discovery of Dual Target Inhibitors against Cyclooxygenases and Leukotriene A4Hydrolyase

(2011) Zheng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis

(2009) C.A.C. Hyde et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lipidomic Analysis of Dynamic Eicosanoid Responses during the Induction and Resolution of Lyme Arthritis

(2009) Victoria A. Blaho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arylpyrrolizines as Inhibitors of Microsomal Prostaglandin E2Synthase-1 (mPGES-1) or as Dual Inhibitors of mPGES-1 and 5-Lipoxygenase (5-LOX)

(2009) Andy J. Liedtke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

Discovery of Multitarget Inhibitors by Combining Molecular Docking with Common Pharmacophore Matching

(2008) Dengguo Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microsomal Prostaglandin E2Synthase-1 (mPGES-1): A Novel Anti-Inflammatory Therapeutic Target

(2008) Richard W. Friesen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pirinixic Acid Derivatives as Novel Dual Inhibitors of Microsomal Prostaglandin E2Synthase-1 and 5-Lipoxygenase

(2008) Andreas Koeberle et al.   JOURNAL OF MEDICINAL CHEMISTRY

MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

(2008) D. Xu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Finding multiple target optimal intervention in disease-related molecular network

(2008) Kun Yang et al.   Molecular Systems Biology

Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors

(2008) G.F. Sud’ina et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Development and validation of a high-performance liquid chromatography–electrospray mass spectrometry method for the simultaneous determination of 23 eicosanoids

(2007) Anthony J. Blewett et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS