The multicellular signalling network of ovarian cancer metastases

High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification

(2021) Siel Olbrecht et al.   Genome Medicine

Choice of library size normalization and statistical methods for differential gene expression analysis in balanced two-group comparisons for RNA-seq studies

(2020) Xiaohong Li et al.   BMC GENOMICS

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer

(2020) Anders Etzerodt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of Wnt pathway molecules is associated with disease outcome in metastatic high-grade serous carcinoma

(2020) Michal Chehover et al.   VIRCHOWS ARCHIV

Determining sequencing depth in a single-cell RNA-seq experiment

(2020) Martin Jinye Zhang et al.   Nature Communications

Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma

(2020) Ludwig Geistlinger et al.   CANCER RESEARCH

Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways

(2020) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A single-cell landscape of high-grade serous ovarian cancer

(2020) Benjamin Izar et al.   NATURE MEDICINE

ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment

(2020) Chi-Lam Au-Yeung et al.   Nature Communications

PRMT5/Wnt4 axis promotes lymph-node metastasis and proliferation of laryngeal carcinoma

(2020) Nan Wang et al.   Cell Death & Disease

Adipocytes: active facilitators in epithelial ovarian cancer progression?

(2020) Lan Dai et al.   Journal of Ovarian Research

Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin

(2020) Eun Jeong Park et al.   Frontiers in Cell and Developmental Biology

WNT4 secreted by tumor tissues promotes tumor progression in colorectal cancer by activation of the Wnt/β-catenin signalling pathway

(2020) Dongmei Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

WNT/β-catenin pathway activation correlates with immune exclusion across human cancers

(2019) Jason J. Luke et al.   CLINICAL CANCER RESEARCH

Specificity, versatility, and control of TGF-β family signaling

(2019) Rik Derynck et al.   Science Signaling

Wnt Signaling in Ovarian Cancer Stemness, EMT, and Therapy Resistance

(2019) Teeuwssen et al.   Journal of Clinical Medicine

Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells

(2019) Elena Y. Komarova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis

(2019) Vu Hong Loan Nguyen et al.   Journal of Ovarian Research

Bias, robustness and scalability in single-cell differential expression analysis

(2018) Charlotte Soneson et al.   NATURE METHODS

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

(2018) Andras Ladanyi et al.   ONCOGENE

Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites

(2018) Annika Unger et al.   Frontiers in Immunology

Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment

(2018) Silke Reinartz et al.   Molecular Oncology

The obese adipose tissue microenvironment in cancer development and progression

(2018) Daniela F. Quail et al.   Nature Reviews Endocrinology

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

(2018) Takeshi Motohara et al.   ONCOGENE

Identification of grade and origin specific cell populations in serous epithelial ovarian cancer by single cell RNA-seq

(2018) Andrew J. Shih et al.   PLoS One

IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis

(2018) Landon Browning et al.   Cancer Management and Research

Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells

(2017) Boris J. Winterhoff et al.   GYNECOLOGIC ONCOLOGY

EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells

(2017) Ville Koistinen et al.   MATRIX BIOLOGY

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment

(2017) Thomas Worzfeld et al.   MOLECULAR & CELLULAR PROTEOMICS

Power analysis of single-cell RNA-sequencing experiments

(2017) Valentine Svensson et al.   NATURE METHODS

Immunological Functions of the Omentum

(2017) Selene Meza-Perez et al.   TRENDS IN IMMUNOLOGY

The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

(2017) Minh Ngoc Duong et al.   Oncotarget

A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications

(2017) Ashraful Haque et al.   Genome Medicine

The Unique Molecular and Cellular Microenvironment of Ovarian Cancer

(2017) Thomas Worzfeld et al.   Frontiers in Oncology

Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche

(2016) Fabrizio Miranda et al.   CANCER CELL

Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo

(2016) Ville Koistinen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases

(2016) Justyna Mikuła-Pietrasik et al.   Cell Death & Disease

The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization

(2016) Florian Finkernagel et al.   Oncotarget

Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo

(2015) Justyna Mikuła-Pietrasik et al.   CLINICAL & EXPERIMENTAL METASTASIS

THEMIS: a critical TCR signal regulator for ligand discrimination

(2015) Nicholas RJ Gascoigne et al.   CURRENT OPINION IN IMMUNOLOGY

Systematic Mapping of WNT-FZD Protein Interactions Reveals Functional Selectivity by Distinct WNT-FZD Pairs

(2015) Jacomijn P. Dijksterhuis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state

(2015) Till Adhikary et al.   NUCLEIC ACIDS RESEARCH

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype

(2015) Verena Rohnalter et al.   Oncotarget

Mesothelial cells in tissue repair and fibrosis

(2015) Steven E. Mutsaers et al.   Frontiers in Pharmacology

Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion

(2014) Hilary A. Kenny et al.   JOURNAL OF CLINICAL INVESTIGATION

Heat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1/constitutive heat shock element-binding factor-dependent mechanism

(2014) Eduardo Ferat-Osorio et al.   Journal of Inflammation-London

Prognostic and Therapeutic Relevance of Molecular Subtypes in High-Grade Serous Ovarian Cancer

(2014) Gottfried E. Konecny et al.   JNCI-Journal of the National Cancer Institute

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Semaphorins and plexins as therapeutic targets

(2014) Thomas Worzfeld et al.   NATURE REVIEWS DRUG DISCOVERY

Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers

(2013) Kai Hung Tiong et al.   APOPTOSIS

β-Catenin-dependent pathway activation by both promiscuous “canonical” WNT3a–, and specific “noncanonical” WNT4– and WNT5a–FZD receptor combinations with strong differences in LRP5 and LRP6 dependency

(2013) Larisa Ring et al.   CELLULAR SIGNALLING

Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer

(2013) L. R. Howe et al.   CLINICAL CANCER RESEARCH

Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: Correlation of CD163 expression, cytokine levels and early relapse

(2013) Silke Reinartz et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts

(2013) Tat-San Lau et al.   JOURNAL OF PATHOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Cell–cell and cell–matrix dynamics in intraperitoneal cancer metastasis

(2012) Katharine L. Sodek et al.   CANCER AND METASTASIS REVIEWS

Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

(2012) Balázs Győrffy et al.   ENDOCRINE-RELATED CANCER

Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself

(2012) Michael Luong et al.   Journal of Inflammation-London

Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion

(2011) Yuan Zhang et al.   CANCER LETTERS

Fibroblasts in omentum activated by tumor cells promote ovarian cancer growth, adhesion and invasiveness

(2011) J. Cai et al.   CARCINOGENESIS

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium

(2011) Marcin P. Iwanicki et al.   Cancer Discovery

Ovarian Cancer Development and Metastasis

(2010) Ernst Lengyel   AMERICAN JOURNAL OF PATHOLOGY

Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion

(2010) S Tsuji et al.   BRITISH JOURNAL OF CANCER

Expanding role of ubiquitination in NF-κB signaling

(2010) Siqi Liu et al.   CELL RESEARCH

Omental Milky Spots Develop in the Absence of Lymphoid Tissue-Inducer Cells and Support B and T Cell Responses to Peritoneal Antigens

(2009) Javier Rangel-Moreno et al.   IMMUNITY

A new real-time PCR method to overcome significant quantitative inaccuracy due to slight amplification inhibition

(2008) Michele Guescini et al.   BMC BIOINFORMATICS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Membrane proteins and membrane proteomics

(2008) Sandra Tan et al.   PROTEOMICS