Involvement of Ceramides in Non-Alcoholic Fatty Liver Disease (NAFLD) Atherosclerosis (ATS) Development: Mechanisms and Therapeutic Targets

Immunity as Cornerstone of Non-Alcoholic Fatty Liver Disease: The Contribution of Oxidative Stress in the Disease Progression

(2021) Marcello Dallio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ceramide Scores Predict Cardiovascular Risk in the Community

(2021) Vlad C. Vasile et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes

(2021) Subroto Chatterjee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterizing a common CERS2 polymorphism in a mouse model of metabolic disease and in subjects from the Utah CAD Study

(2021) Rebekah J Nicholson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Novel Nutraceuticals Mixture Improves Liver Steatosis by Preventing Oxidative Stress and Mitochondrial Dysfunction in a NAFLD Model

(2021) Moris Sangineto et al.   Nutrients

Trends in the Use of Sphingosine 1 Phosphate in Age-Related Diseases: A Scientometric Research Study (1992-2020)

(2021) Qiong He et al.   Journal of Diabetes Research

Roles of Ceramides in Non-Alcoholic Fatty Liver Disease

(2021) Eric Hajduch et al.   Journal of Clinical Medicine

Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease

(2021) Jae-Hwi Song et al.   Biomolecules & Therapeutics

Alpha‐mangostin improves endothelial dysfunction in db/db mice through inhibition of aSMase/ceramide pathway

(2021) Meng Jiang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ceramides and other sphingolipids as drivers of cardiovascular disease

(2021) Ran Hee Choi et al.   Nature Reviews Cardiology

Neutral sphingomyelinase‐2 and cardiometabolic diseases

(2021) Sardar Sindhu et al.   Obesity Reviews

Promising Novel Biomarkers in Cardiovascular Diseases

(2021) Brigitte Sipos et al.   Applied Sciences-Basel

Ceramides and Sphingosino-1-Phosphate in Obesity

(2021) Ilona Juchnicka et al.   Frontiers in Endocrinology

Circulating ceramides as biomarkers of cardiovascular disease: Evidence from phenotypic and genomic studies

(2021) Kathryn A. McGurk et al.   ATHEROSCLEROSIS

Sphingolipids in metabolic disease: The good, the bad, and the unknown

(2021) Christopher D. Green et al.   Cell Metabolism

Glucagon-Like Peptide 1 Receptor Agonists, Carotid Atherosclerosis, and Cardiovascular Outcomes

(2021) Guillaume Marquis-Gravel et al.   DIABETES CARE

A Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis

(2021) Brianna M. Quinville et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

N-Palmitoyl Serinol Stimulates Ceramide Production through a CB1-Dependent Mechanism in In Vitro Model of Skin Inflammation

(2021) Kyong-Oh Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

(2021) Inês C. M. Simões et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analytical considerations for reducing the matrix effect for the sphingolipidome quantification in whole blood

(2021) Dezhen Wang et al.   Bioanalysis

Effect of Coffee Consumption on Non-Alcoholic Fatty Liver Disease Incidence, Prevalence and Risk of Significant Liver Fibrosis: Systematic Review with Meta-Analysis of Observational Studies

(2021) Maryam Ebadi et al.   Nutrients

Ceramides and phospholipids are downregulated with liraglutide treatment: results from the LiraFlame randomized controlled trial

(2021) Emilie H Zobel et al.   BMJ Open Diabetes Research & Care

Predictive Added Value of Selected Plasma Lipids to a Re-estimated Minimal Risk Tool

(2021) Antonella Bodini et al.   Frontiers in Cardiovascular Medicine

Myriocin and d-PDMP ameliorate atherosclerosis in ApoE−/− mice via reducing lipid uptake and vascular inflammation

(2020) Zemou Yu et al.   CLINICAL SCIENCE

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

Metabolic inflammation - a role for hepatic inflammatory pathways as driver of comorbidities in non-alcoholic fatty liver disease (NAFLD)?

(2020) Nadine Gehrke et al.   GASTROENTEROLOGY

Ceramides ‐ a cause of insulin resistance in NAFLD in both murine models and humans

(2020) Hannele Yki‐Järvinen   HEPATOLOGY

Breaking through the surface: more to learn about lipids and cardiovascular disease

(2020) Justin B. Echouffo-Tcheugui et al.   JOURNAL OF CLINICAL INVESTIGATION

Murine Epidermal Ceramide Synthase 4 is a Key Regulator of Skin Barrier Homeostasis

(2020) Franziska Peters et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Circulating ceramide ratios and risk of vascular brain aging and dementia

(2020) Emer R. McGrath et al.   Annals of Clinical and Translational Neurology

Heart-Type Fatty Acid-Binding Protein (H-FABP) and Its Role as a Biomarker in Heart Failure: What Do We Know So Far?

(2020) Richard Rezar et al.   Journal of Clinical Medicine

DES1: A Key Driver of Lipotoxicity in Metabolic Disease

(2020) Jeremy T. Blitzer et al.   DNA AND CELL BIOLOGY

Plasma Ceramides in Relation to Coronary Plaque Characterization Determined by Optical Coherence Tomography

(2020) Weili Pan et al.   Journal of Cardiovascular Translational Research

Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms—A Narrative Review

(2020) Jibran A. Wali et al.   Nutrients

Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

(2020) Moris Sangineto et al.   Cancers

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH

(2020) Francesca Zanieri et al.   Cells

Role of bioactive sphingolipids in physiology and pathology

(2020) Ana Gomez-Larrauri et al.   Essays in Biochemistry

Association between ceramides and coronary artery stenosis in patients with coronary artery disease

(2020) Chenchen Tu et al.   Lipids in Health and Disease

The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet

(2020) Emmanuel Somm et al.   Translational Research

An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease

(2020) Ke Pei et al.   Biomed Research International

Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases

(2020) Suryaprakash Raichur   Frontiers in Endocrinology

Ceramides in Adipose Tissue

(2020) Ying Li et al.   Frontiers in Endocrinology

The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: A meta-analysis of 11 epidemiological studies

(2020) Umar Hayat et al.   Annals of Hepatology

Why and how increased plasma ceramides predict future cardiovascular events?

(2020) Katariina Öörni et al.   ATHEROSCLEROSIS

Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP-/- mice

(2020) Abudukadier Abulizi et al.   JOURNAL OF LIPID RESEARCH

Effects of a Low Dose of Caffeine Alone or as Part of a Green Coffee Extract, in a Rat Dietary Model of Lean Non-Alcoholic Fatty Liver Disease without Inflammation

(2020) Ana Magdalena Velázquez et al.   Nutrients

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α

(2020) Fatema Al-Rashed et al.   Scientific Reports

Sphingolipids and Diagnosis, Prognosis, and Organ Damage in Systemic Lupus Erythematosus

(2020) Olivia C. Harden et al.   Frontiers in Immunology

The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines

(2020) Bianca C. Field et al.   Frontiers in Endocrinology

Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging

(2020) Astrid M. Moerman et al.   JOURNAL OF LIPID RESEARCH

Ceramides in Metabolism: Key Lipotoxic Players

(2020) Bhagirath Chaurasia et al.   Annual Review of Physiology

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

(2019) Sarah M. Turpin-Nolan et al.   Cell Reports

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

(2019) Suryaprakash Raichur et al.   Molecular Metabolism

FTY720/Fingolimod Decreases Hepatic Steatosis and Expression of Fatty Acid Synthase in Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

(2019) Timothy D. Rohrbach et al.   JOURNAL OF LIPID RESEARCH

Ceramide synthase inhibition by fumonisins: a perfect storm of perturbed sphingolipid metabolism, signaling and disease

(2019) Ronald T. Riley et al.   JOURNAL OF LIPID RESEARCH

Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients

(2019) Mika Hilvo et al.   EUROPEAN HEART JOURNAL

Impact of exenatide on mitochondrial lipid metabolism in mice with nonalcoholic steatohepatitis

(2019) Srilaxmi Kalavalapalli et al.   JOURNAL OF ENDOCRINOLOGY

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

Lowering ceramides to overcome diabetes

(2019) Christine M. Kusminski et al.   SCIENCE

Hepatocyte Elovl6 determines ceramide acyl‐chain length and hepatic insulin sensitivity in mice

(2019) Takashi Matsuzaka et al.   HEPATOLOGY

Metabolic and Vascular Effect of the Mediterranean Diet

(2019) Antonino Tuttolomondo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cholesterol Acceptors Regulate the Lipidome of Macrophage Foam Cells

(2019) Antoni Paul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overeating saturated fat promotes fatty liver and ceramides compared to polyunsaturated fat: a randomized trial

(2019) Fredrik Rosqvist et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Variations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities

(2019) Lisa Rein-Fischboeck et al.   Lipids in Health and Disease

The Role of Ceramides in Insulin Resistance

(2019) Emilia Sokolowska et al.   Frontiers in Endocrinology

Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease

(2019) Meng Jiang et al.   Frontiers in Endocrinology

A tissue‐specific screen of ceramide expression in aged mice identifies ceramide synthase‐1 and ceramide synthase‐5 as potential regulators of fiber size and strength in skeletal muscle

(2019) Bettina Tosetti et al.   AGING CELL

Fenretinide treatment accelerates atherosclerosis development in apoE‐deficient mice in spite of beneficial metabolic effects

(2019) Marco Busnelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases

(2019) Ye-Ryung Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis

(2019) Rui-Xu Yang et al.   Lipids in Health and Disease

Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides

(2019) Varman T. Samuel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity

(2019) Samar M. Hammad et al.   PLoS One

Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats

(2019) Bei-bo Cai et al.   ACTA PHARMACOLOGICA SINICA

Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism

(2019) Zhongyang Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Machine learning reveals serum sphingolipids as cholesterol-independent biomarkers of coronary artery disease

(2019) Annelise M. Poss et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation

(2019) Kazuhiro Ishimaru et al.   Scientific Reports

Plasma Ceramides

(2018) Jeffrey W. Meeusen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe−/−MiceHighlights

(2018) Tom Lallemand et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PCSK9 inhibition alters the lipidome of plasma and lipoprotein fractions

(2018) Mika Hilvo et al.   ATHEROSCLEROSIS

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Strong Heart, Low Ceramides

(2018) William L. Holland et al.   DIABETES

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

(2018) Panu K. Luukkonen et al.   DIABETES CARE

Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

(2018) Maija Ruuth et al.   EUROPEAN HEART JOURNAL

Lipotoxicity and the gut-liver axis in NASH pathogenesis

(2018) Fabio Marra et al.   JOURNAL OF HEPATOLOGY

Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?

(2018) Amedeo Lonardo et al.   JOURNAL OF HEPATOLOGY

Additional Diagnostic Value of Growth Differentiation Factor-15 (GDF-15) to N-Terminal B-Type Natriuretic Peptide (NT-proBNP) in Patients with Different Stages of Heart Failure

(2018) Jiao Li et al.   MEDICAL SCIENCE MONITOR

Az apolipoprotein M és a szfingozin-1-foszfát tengely jelentősége az érelmeszesedés kialakulásának gátlásában

(2018) Bíborka Nádró et al.   ORVOSI HETILAP

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression

(2018) Francesco Bellanti et al.   Redox Biology

Soluble ST2 is a biomarker for cardiovascular mortality related to abnormal glucose metabolism in high-risk subjects

(2018) Marina Cardellini et al.   ACTA DIABETOLOGICA

Sphingolipid metabolism in non-alcoholic fatty liver diseases

(2018) Marion Régnier et al.   BIOCHIMIE

Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia

(2018) Dattesh Verlekar et al.   Cell Death & Disease

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

(2018) Nigel Turner et al.   Nature Communications

Mechanisms of Fumonisin B1 Toxicity: A Computational Perspective beyond the Ceramide Synthases Inhibition

(2018) Luca Dellafiora et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

Ceramides as Novel Disease Biomarkers

(2018) Jennifer Kurz et al.   TRENDS IN MOLECULAR MEDICINE

Ceramides and depression: A systematic review

(2017) Adam Dinoff et al.   JOURNAL OF AFFECTIVE DISORDERS

suPAR and chronic kidney disease—a podocyte story

(2017) Martin Zeier et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Sphingolipids and Lipoproteins in Health and Metabolic Disorders

(2017) Jahangir Iqbal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

(2017) Max C. Petersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ceramide synthase-4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through the nuclear factor-κB signaling pathway

(2017) Jinwu Chen et al.   Oncology Letters

Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma

(2017) Zheng Wang et al.   Oncotarget

Role of B‐Type Natriuretic Peptide and N‐Terminal Prohormone BNP as Predictors of Cardiovascular Morbidity and Mortality in Patients With a Recent Coronary Event and Type 2 Diabetes Mellitus

(2017) Emil Wolsk et al.   Journal of the American Heart Association

High-Density Lipoprotein–Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1Highlights

(2016) Mario Ruiz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sphingolipids Contribute to Human Atherosclerotic Plaque InflammationHighlights

(2016) Andreas Edsfeldt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 CohortHighlights

(2016) Aki S. Havulinna et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology

(2016) Mireia Casasampere et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol

(2016) Reijo Laaksonen et al.   EUROPEAN HEART JOURNAL

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

(2016) Frank J. Gonzalez et al.   GASTROENTEROLOGY

Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity

(2016) Dominic Gosejacob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis

(2016) Hailiang Liu et al.   JOURNAL OF LIPID RESEARCH

Preclinical development of a C6-ceramide NanoLiposome, a novel sphingolipid therapeutic

(2015) Mark Kester et al.   BIOLOGICAL CHEMISTRY

Microsomal Triglyceride Transfer Protein Transfers and Determines Plasma Concentrations of Ceramide and Sphingomyelin but Not Glycosylceramide

(2015) Jahangir Iqbal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-atherosclerotic effects of the glucagon-like peptide-1 (GLP-1) based therapies in patients with type 2 Diabetes Mellitus: A meta-analysis

(2015) Xiaoyan Song et al.   Scientific Reports

Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis

(2015) Takhar Kasumov et al.   PLoS One

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Renal Glycosphingolipid Metabolism Is Dysfunctional in Lupus Nephritis

(2014) T. K. Nowling et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

(2014) P. J. Meakin et al.   MOLECULAR AND CELLULAR BIOLOGY

Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages

(2013) Junfei Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rapid regression of atherosclerosis with MTP inhibitor treatment

(2013) Bernd Hewing et al.   ATHEROSCLEROSIS

The complexity of sphingolipid biosynthesis in the endoplasmic reticulum

(2013) Rotem Tidhar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The pro-inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is associated with incident type 2 diabetes among overweight but not obese individuals with impaired glucose regulation: effect modification by smoking and body weight status

(2013) A. Heraclides et al.   DIABETOLOGIA

Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720

(2012) Janee Gelineau-van Waes et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide

(2012) M. J. Watt et al.   DIABETOLOGIA

Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice

(2011) Suthat Liangpunsakul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Modulators of Sphingolipid Metabolism Reduce Lung Inflammation

(2011) Maria Cristina Dechecchi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Phospholipid transfer activity of microsomal triglyceride transfer protein produces apolipoprotein B and reduces hepatosteatosis while maintaining low plasma lipids in mice

(2011) Irani Khatun et al.   HEPATOLOGY

A Critical Role for Ceramide Synthase 2 in Liver Homeostasis

(2010) Yael Pewzner-Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response

(2009) Stefka D. Spassieva et al.   BIOCHEMICAL JOURNAL

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING