Journal
TRENDS IN MOLECULAR MEDICINE
Volume 25, Issue 1, Pages 20-32Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2018.10.009
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Funding
- Landesoffensive zur Entwicklung wissenschaftlich-okonomischer Exzellenz (LOEWE), Zentrum: Translationale Medizin und Pharmakologie
- German Research Association (DFG) [SFB 1039]
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Ceramides are sphingolipids and integral components of the eukaryotic cell membrane. Apart from providing structural integrity, ceramides have also been shown to act as second messengers in cell signaling processes. In recent publications, ceramide modulation has been reported in pathological conditions such as cancer, diabetes, Alzheimer's disease (AD), coronary artery disease (CAD), multiple sclerosis (MS), as well as depression. Ceramides or ceramide panel combinations have been proposed as specific disease biomarkers that could be detected in diseased tissue, synovial fluid, cerebrospinal fluid (CSF), and blood. This article reviews ceramide modulation in a selection of different diseases and the potential use of ceramides as biomarkers in diagnostics, determination of disease stage and personalized medicine.
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