Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

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HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose

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Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

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Correction: Characterization of ferroptosis in kidney tubular cell death under diabetic conditions

(2021) Seonghun Kim et al.   Cell Death & Disease

Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

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Mitochondrial regulation of ferroptosis

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Ferroptosis is involved in the anti‑tumor effect of lycorine in renal cell carcinoma cells

(2021) Yang Du et al.   Oncology Letters

Targeting Ferroptosis Attenuates Interstitial Inflammation and Kidney Fibrosis

(2021) Lu Zhou et al.   Kidney Diseases

Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models

(2021) Xiaoqin Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis

(2020) Zhaoxin Hu et al.   Cell Death & Disease

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Ferroptosis in Cancer Cell Biology

(2020) Christina M. Bebber et al.   Cancers

Diverse Role of TGF-β in Kidney Disease

(2020) Yue-Yu Gu et al.   Frontiers in Cell and Developmental Biology

A new survival model based on ferroptosis-related genes for prognostic prediction in clear cell renal cell carcinoma

(2020) Guangzhen Wu et al.   Aging-US

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

(2020) Yi Lu et al.   Science Translational Medicine

Quercetin alleviates acute kidney injury by inhibiting ferroptosis

(2020) Yue Wang et al.   Journal of Advanced Research

Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo

(2020) Ines Cabrita et al.   Nature Communications

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Ferroptosis involves in renal tubular cell death in diabetic nephropathy

(2020) Yue Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

(2019) Rainer Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nephroprotective Effect of Embryonic Stem Cells Reducing Lipid Peroxidation in Kidney Injury Induced by Cisplatin

(2019) Monica Maribel Mata-Miranda et al.   Oxidative Medicine and Cellular Longevity

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

The release and activity of HMGB1 in ferroptosis

(2019) Qirong Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

N-Acetylcysteine Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting the C5a Receptor

(2019) Shuai Huang et al.   Biomed Research International

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

(2019) Wen-Hsuan Yang et al.   Cell Reports

Interactions of high mobility group box protein 1 (HMGB1) with nucleic acids: Implications in DNA repair and immune responses

(2019) Pooja Mandke et al.   DNA REPAIR

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways

(2019) J. Catharina Duvigneau et al.   Antioxidants

Diabetic Kidney Disease

(2019) Mohammed Akhtar et al.   ADVANCES IN ANATOMIC PATHOLOGY

Iron homeostasis and oxidative stress: An intimate relationship

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Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction

(2018) Michael J. Kerins et al.   CANCER SCIENCE

The tumor suppressor protein p53 and the ferroptosis network

(2018) Rui Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

(2018) Heike Miess et al.   ONCOGENE

Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease

(2018) Sanne van Raaij et al.   Scientific Reports

Early intraoperative iron-binding proteins are associated with acute kidney injury after cardiac surgery

(2018) Nora Choi et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

A Dual Role of Heme Oxygenase-1 in Cancer Cells

(2018) Shih-Kai Chiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

The in vivo evidence for regulated necrosis

(2017) Wulf Tonnus et al.   IMMUNOLOGICAL REVIEWS

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

(2017) Linda Xiaoyan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

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BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

Renal cell carcinoma

(2017) James J. Hsieh et al.   Nature Reviews Disease Primers

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas

(2016) Xiaohu Tang et al.   CANCER RESEARCH

Ferroptosis: process and function

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Evaluations of lipid peroxidation and inflammation in short-term glycerol-induced acute kidney injury in rats

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Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer

(2016) Johannes Schödel et al.   EUROPEAN UROLOGY

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

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Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Nicholas J Kassebaum et al.   LANCET

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells

(2016) Takashi Kasukabe et al.   ONCOLOGY REPORTS

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Possible therapeutic impact of the iron chelation on renal fibrosis

(2015) Kouichi Tamura et al.   HYPERTENSION RESEARCH

Association between renal iron accumulation and renal interstitial fibrosis in a rat model of chronic kidney disease

(2015) Yoshiro Naito et al.   HYPERTENSION RESEARCH

Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease

(2015) Li Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis

(2015) Y. Scindia et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND)

(2015) Sudha K. Iyengar et al.   PLoS Genetics

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

AKI Associated with Cardiac Surgery

(2014) R. H. Thiele et al.   Clinical Journal of the American Society of Nephrology

Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment

(2014) Fred H. Menko et al.   Familial Cancer

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Iron Chelation by Deferoxamine Prevents Renal Interstitial Fibrosis in Mice with Unilateral Ureteral Obstruction

(2014) Yasumasa Ikeda et al.   PLoS One

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of iron transport

(2013) David M. Frazer et al.   BIOFACTORS

Dietary iron restriction prevents further deterioration of renal damage in a chronic kidney disease rat model

(2013) Yoshiro Naito et al.   JOURNAL OF HYPERTENSION

Smac-Mimetic-Induced Epithelial Cell Death Reduces the Growth of Renal Cysts

(2013) L. X. Fan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

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Hepcidin and iron homeostasis

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Effect of iron restriction on renal damage and mineralocorticoid receptor signaling in a rat model of chronic kidney disease

(2012) Yoshiro Naito et al.   JOURNAL OF HYPERTENSION

Plasma and Urinary Heme Oxygenase-1 in AKI

(2012) R. A. Zager et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats

(2011) Francisca Rodriguez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

(2011) Wing-Hang Tong et al.   CANCER CELL

The contribution of chronic kidney disease to the global burden of major noncommunicable diseases

(2011) William G. Couser et al.   KIDNEY INTERNATIONAL

Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure

(2010) Olivier Boutaud et al.   FREE RADICAL BIOLOGY AND MEDICINE

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Advanced Glycation end Products, Oxidative Stress and Diabetic Nephropathy

(2010) Sho-ichi Yamagishi et al.   Oxidative Medicine and Cellular Longevity

Induction of Heme Oxygenase-1 Can Halt and Even Reverse Renal Tubule-Interstitial Fibrosis

(2010) Matheus Correa-Costa et al.   PLoS One

Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

(2009) Sang Choel Lee et al.   KIDNEY INTERNATIONAL

Rhabdomyolysis and Acute Kidney Injury

(2009) Xavier Bosch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rosiglitazone Treatment Reduces Diabetic Neuropathy in Streptozotocin-Treated DBA/2J Mice

(2008) Timothy D. Wiggin et al.   ENDOCRINOLOGY

Heme Oxygenase-1 Deficiency Promotes Epithelial-Mesenchymal Transition and Renal Fibrosis

(2008) J.-H. Kie et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY