Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo
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Title
Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo
Authors
Keywords
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Journal
Nature Communications
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-08-28
DOI
10.1038/s41467-020-18104-5
References
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Related references
Note: Only part of the references are listed.- Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A
- (2020) Raquel Centeio et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells
- (2020) Ines Cabrita et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels
- (2020) Shihab Shah et al. Science Signaling
- TMEM16A Ca2+-activated Cl− channel inhibition ameliorates acute pancreatitis via the IP3R/Ca2+/NFκB/IL-6 signaling pathway
- (2020) Qinghua Wang et al. Journal of Advanced Research
- Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A
- (2019) Rainer Schreiber et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Contribution of Anoctamins to Cell Survival and Cell Death
- (2019) Karl Kunzelmann et al. Cancers
- Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways
- (2019) Kent Miner et al. Frontiers in Pharmacology
- Plasma membrane–localized TMEM16 proteins are indispensable for expression of CFTR
- (2019) Roberta Benedetto et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Phosphatidylinositol 4,5-bisphosphate (PIP2) and Ca2+ are both required to open the Cl- channel TMEM16A
- (2019) Maiwase Tembo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis
- (2019) David Crottès et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1)
- (2018) José J. De Jesús-Pérez et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1
- (2018) Joana Lérias et al. CELLULAR SIGNALLING
- CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A
- (2018) Aarushi Sharma et al. PLoS One
- HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease
- (2018) Andre Kraus et al. KIDNEY INTERNATIONAL
- Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors
- (2018) Yohan Seo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Differential effects of anoctamins on intracellular calcium signals
- (2017) Inês Cabrita et al. FASEB JOURNAL
- Cytoplasmic Cl−couples membrane remodeling to epithelial morphogenesis
- (2017) Mu He et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ciliary Mechanisms of Cyst Formation in Polycystic Kidney Disease
- (2017) Ming Ma et al. Cold Spring Harbor Perspectives in Biology
- Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function
- (2016) Axel R. Concepcion et al. JOURNAL OF CLINICAL INVESTIGATION
- P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells
- (2016) Andre Kraus et al. Purinergic Signalling
- Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2
- (2016) Yohan Seo et al. PLoS One
- Small Molecule-facilitated Degradation of ANO1 Protein
- (2014) Anke Bill et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of Ca2+-activated Cl−channel ANO1 by localized Ca2+signals
- (2014) Xin Jin et al. JOURNAL OF PHYSIOLOGY-LONDON
- The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function
- (2014) Diana Faria et al. KIDNEY INTERNATIONAL
- The secret life of CFTR as a calcium-activated chloride channel
- (2013) Arnaud Billet et al. JOURNAL OF PHYSIOLOGY-LONDON
- Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells
- (2013) Bjoern Buchholz et al. KIDNEY INTERNATIONAL
- Primary cilia are specialized calcium signalling organelles
- (2013) Markus Delling et al. NATURE
- Activation of the Cl- Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor
- (2013) X. Jin et al. Science Signaling
- Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
- (2012) F. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion
- (2011) Bjoern Buchholz et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Expression and Function of Epithelial Anoctamins
- (2010) Rainer Schreiber et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CFTR-Adenylyl Cyclase I Association Responsible for UTP Activation of CFTR in Well-Differentiated Primary Human Bronchial Cell Cultures
- (2010) Wan Namkung et al. MOLECULAR BIOLOGY OF THE CELL
- Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks
- (2009) Xuewen Song et al. HUMAN MOLECULAR GENETICS
- Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells
- (2009) Kalani L. Raphael et al. KIDNEY INTERNATIONAL
- Polycystic Kidney Disease
- (2008) Peter C. Harris et al. Annual Review of Medicine
- Small-Molecule CFTR Inhibitors Slow Cyst Growth in Polycystic Kidney Disease
- (2008) B. Yang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
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