Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models

The genetic background significantly impacts the severity of kidney cystic disease in the Pkd1RC/RC mouse model of autosomal dominant polycystic kidney disease.

(2021) Jennifer Arroyo et al.   KIDNEY INTERNATIONAL

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

(2019) Rainer Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Potential of Mitochondria-Targeted Antioxidants to Prevent Oxidative Stress in Pancreatic β-cells

(2019) Lydie Plecitá-Hlavatá et al.   Oxidative Medicine and Cellular Longevity

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

(2019) Liyuan Wang et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis and autophagy in polycystic kidney disease (PKD)

(2019) Kristen L. Nowak et al.   CELLULAR SIGNALLING

Polycystic kidney disease

(2018) Carsten Bergmann et al.   Nature Reviews Disease Primers

Cancer growth regulation by 4-hydroxynonenal

(2017) Ana Cipak Gasparovic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma

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Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

(2017) Linda Xiaoyan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

BID links ferroptosis to mitochondrial cell death pathways

(2017) Sandra Neitemeier et al.   Redox Biology

Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency

(2017) Ming-Yang Chang et al.   Scientific Reports

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evaluation of apoptosis-associated protein (Bcl-2, Bax, cleaved caspase-3 and p53) expression in canine mammary tumors: An immunohistochemical and prognostic study

(2016) Izabella Dolka et al.   RESEARCH IN VETERINARY SCIENCE

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

On the role of 4-hydroxynonenal in health and disease

(2015) Miklós Csala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease

(2015) Li Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel molecular approaches for improving enzymatic and nonenzymatic detoxification of 4-hydroxynonenal: toward the discovery of a novel class of bioactive compounds

(2014) Giancarlo Aldini et al.   FREE RADICAL BIOLOGY AND MEDICINE

3D spheroid model of mIMCD3 cells for studying ciliopathies and renal epithelial disorders

(2014) Rachel H Giles et al.   Nature Protocols

Smac-Mimetic-Induced Epithelial Cell Death Reduces the Growth of Renal Cysts

(2013) L. X. Fan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of Mammalian Iron Homeostasis

(2012) Kostas Pantopoulos et al.   BIOCHEMISTRY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses

(2012) F. Zhang et al.   HAEMATOLOGICA

Heme Oxygenase-1, Oxidation, Inflammation, and Atherosclerosis

(2012) Jesus A. Araujo et al.   Frontiers in Pharmacology

Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses

(2011) Z. Zhang et al.   BLOOD

Polycystin-1 Protein Level Determines Activity of the Gα12/JNK Apoptosis Pathway

(2010) Wanfeng Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation

(2009) Huan Sun et al.   MOLECULAR BIOLOGY REPORTS

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

(2008) Sekiya Shibazaki et al.   HUMAN MOLECULAR GENETICS

A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease

(2008) Xiaogang Li et al.   NATURE MEDICINE