Flavonoids Synergistically Enhance the Anti-Glioblastoma Effects of Chemotherapeutic Drugs

Flavonoids Targeting HIF-1: Implications on Cancer Metabolism

(2021) Marek Samec et al.   Cancers

Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism

(2021) Aranka Brockmueller et al.   Cancers

Silibinin as potential tool againstSARS‐Cov‐2: In silico spikereceptor‐bindingdomain and main protease molecular docking analysis, and in vitro endothelial protective effects

(2021) Antonio Speciale et al.   PHYTOTHERAPY RESEARCH

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

(2021) Kevin Zhai et al.   Cancers

Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles

(2021) Alena Liskova et al.   EPMA Journal

Flavonoids against the SARS-CoV-2 induced inflammatory storm

(2021) Alena Liskova et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention

(2021) Lenka Koklesova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes

(2020) Hyo In Kim et al.   Nutrients

Quercetin and chloroquine synergistically kill glioma cells by inducing organelle stress and disrupting Ca2+ homeostasis

(2020) Eunjung Jang et al.   BIOCHEMICAL PHARMACOLOGY

Neuroprotective effects of icariin in neonatal hypoxia-ischemic brain damage via its anti-apoptotic property

(2020) Mengxia Wang et al.   CHILDS NERVOUS SYSTEM

Flavonoids in Cancer Metastasis

(2020) Alena Liskova et al.   Cancers

Hispidulin: A promising flavonoid with diverse anti-cancer properties

(2020) Kaili Liu et al.   LIFE SCIENCES

Curcumin’s Beneficial Effects on Neuroblastoma: Mechanisms, Challenges, and Potential Solutions

(2020) Kevin Zhai et al.   Biomolecules

Carotenoids in Cancer Metastasis—Status Quo and Outlook

(2020) Lenka Koklesova et al.   Biomolecules

Icariin and Its Metabolites as Potential Protective Phytochemicals Against Alzheimer’s Disease

(2019) Cristina Angeloni et al.   Frontiers in Pharmacology

The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity

(2019) Alessandra Bispo da Silva et al.   BRAIN BEHAVIOR AND IMMUNITY

In vitro and in vivo Study on Glioma Treatment Enhancement by Combining Temozolomide with Calycosin and Formononetin

(2019) Qi Ni et al.   JOURNAL OF ETHNOPHARMACOLOGY

Quercetin and Sodium Butyrate Synergistically Increase Apoptosis in Rat C6 and Human T98G Glioblastoma Cells Through Inhibition of Autophagy

(2019) Matthew A. Taylor et al.   NEUROCHEMICAL RESEARCH

Synergistic effect of arsenic trioxide, vismodegib and temozolomide on glioblastoma

(2019) Costansia Bureta et al.   ONCOLOGY REPORTS

Focus on Formononetin: Anticancer Potential and Molecular Targets

(2019) Ong et al.   Cancers

Human Safety and Pharmacokinetics Study of Orally Administered Icariin: Randomized, Double-Blind, Placebo-Controlled Trial

(2019) E. Sherwood Brown et al.   Natural Product Communications

Formononetin: A Review of Its Anticancer Potentials and Mechanisms

(2019) Kai-Ching Tay et al.   Frontiers in Pharmacology

Synergistic anticancer effects of formononetin and temozolomide on glioma C6 cells

(2018) Xiong Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia

(2018) Abdelmeniem El-Bakoush et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Arsenic trioxide: insights into its evolution to an anticancer agent

(2018) Maneka Hoonjan et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The safety of green tea and green tea extract consumption in adults – Results of a systematic review

(2018) Jiang Hu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Anticancer activity of flavonoids isolated from Achyrocline satureioides in gliomas cell lines

(2018) Priscila Oliveira de Souza et al.   TOXICOLOGY IN VITRO

A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells

(2018) Eroje M. Ahmed et al.   CELLULAR ONCOLOGY

Challenges in the Treatment of Glioblastoma: Multisystem Mechanisms of Therapeutic Resistance

(2018) Evan K. Noch et al.   World Neurosurgery

Epigallocatechin Gallate Preferentially Inhibits O6-Methylguanine DNA-Methyltransferase Expression in Glioblastoma Cells Rather than in Nontumor Glial Cells

(2018) Chao-Ran Xie et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxide

(2017) Michael Gülden et al.   FOOD AND CHEMICAL TOXICOLOGY

Rutin increases the cytotoxicity of temozolomide in glioblastoma via autophagy inhibition

(2017) Pingde Zhang et al.   JOURNAL OF NEURO-ONCOLOGY

The Pharmacological Potential of Rutin

(2017) Aditya Ganeshpurkar et al.   SAUDI PHARMACEUTICAL JOURNAL

Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action

(2017) Renuka Mani et al.   PHYTOCHEMISTRY

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

(2016) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Anti-Cancer Properties of the Naturally Occurring Aphrodisiacs: Icariin and Its Derivatives

(2016) Hui-Li Tan et al.   Frontiers in Pharmacology

Endogenous and exogenous mediators of quercetin bioavailability

(2015) Yi Guo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C

(2015) Nu T. Lu et al.   PHYTOTHERAPY RESEARCH

Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway

(2015) Shang Li et al.   Scientific Reports

Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells

(2014) José E. Vargas et al.   Biochemistry and Cell Biology

Synergistic Anti-Cancer Effects of Icariin and Temozolomide in Glioblastoma

(2014) Lijuan Yang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Hispidulin Enhances the Anti-Tumor Effects of Temozolomide in Glioblastoma by Activating AMPK

(2014) YanGang Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Pine (Pinus morrisonicola Hayata) Needle Extracts Sensitize GBM8901 Human Glioblastoma Cells to Temozolomide by Downregulating Autophagy and O6-Methylguanine-DNA Methyltransferase Expression

(2014) Chia-Leng Liao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

EGCG inhibits properties of glioma stem-like cells and synergizes with temozolomide through downregulation of P-glycoprotein inhibition

(2014) Yong Zhang et al.   JOURNAL OF NEURO-ONCOLOGY

Rutin: therapeutic potential and recent advances in drug delivery

(2013) Shrestha Sharma et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Status Quo—Standard-of-Care Medical and Radiation Therapy for Glioblastoma

(2012) Kevin P. Becker et al.   CANCER JOURNAL

Safety and anti-HCV effect of prolonged intravenous silibinin in HCV genotype 1 subjects in the immediate liver transplant period

(2012) Rafael Bárcena et al.   JOURNAL OF HEPATOLOGY

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

(2011) Brahma N. Singh et al.   BIOCHEMICAL PHARMACOLOGY

Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models

(2011) Thomas C. Chen et al.   CANCER LETTERS

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

(2011) Derliz Mereles et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glioblastoma survival in the United States before and during the temozolomide era

(2011) Derek R. Johnson et al.   JOURNAL OF NEURO-ONCOLOGY

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

(2011) E. L. Kim et al.   NEURO-ONCOLOGY

Synergistic Effects of Arsenic Trioxide and Silibinin on Apoptosis and Invasion in Human Glioblastoma U87MG Cell Line

(2011) Majid Zaki Dizaji et al.   NEUROCHEMICAL RESEARCH

Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer

(2010) Gagan Deep et al.   CANCER AND METASTASIS REVIEWS

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Standard Therapy for Glioblastoma— A Review of Where We Are

(2010) Ryo NISHIKAWA   NEUROLOGIA MEDICO-CHIRURGICA