Carotenoids in Cancer Metastasis—Status Quo and Outlook

Exopolysaccharides from milk fermented by lactic acid bacteria enhance dietary carotenoid bioavailability in humans in a randomized crossover trial and in rats

(2020) Masashi Morifuji et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Carotenoids and their role in cancer prevention

(2020) Joe L. Rowles et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer

(2020) Laleh Arzi et al.   LIFE SCIENCES

Improving the cancer prevention/treatment role of carotenoids through various nano-delivery systems

(2020) Mahboobeh Zare et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses

(2020) Peter Kubatka et al.   MOLECULES

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

(2020) Lenka Koklesova et al.   EPMA Journal

β-Carotene exerts anti-colon cancer effects by regulating M2 macrophages and activated fibroblasts

(2020) Na Youn Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dietary carotenoids in cancer chemoprevention and chemotherapy: A review of emerging evidence

(2020) Ramesh Kumar Saini et al.   PHARMACOLOGICAL RESEARCH

Lycopene Inhibits Epithelial–Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway

(2020) Ran Wang et al.   Drug Design Development and Therapy

Flavonoids in Cancer Metastasis

(2020) Alena Liskova et al.   Cancers

Prostate cancer management: long-term beliefs, epidemic developments in the early twenty-first century and 3PM dimensional solutions

(2020) Radek Kucera et al.   EPMA Journal

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

(2020) Marek Samec et al.   EPMA Journal

Optimal multiparametric set-up modelled for best survival outcomes in palliative treatment of liver malignancies: unsupervised machine learning and 3 PM recommendations

(2020) Elisha Goldstein et al.   EPMA Journal

Implications of flavonoids as potential modulators of cancer neovascularity

(2020) Alena Liskova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Liquid Biopsy is Instrumental for 3PM Dimensional Solutions in Cancer Management

(2020) Alena Liskova et al.   Journal of Clinical Medicine

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back

(2020) Lenka Koklesova et al.   Cancers

Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib

(2020) Jia Xiong Ming et al.   JOURNAL OF ETHNOPHARMACOLOGY

Vaginal dryness: individualised patient profiles, risks and mitigating measures

(2019) Vadym Goncharenko et al.   EPMA Journal

Dietary Phytochemicals Targeting Cancer Stem Cells

(2019) Alena Liskova et al.   MOLECULES

β-Carotene 15, 15′-oxygenase inhibits cancer cell stemness and metastasis by regulating differentiation-related miRNAs in human neuroblastoma

(2019) Yoo Sun Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nanoencapsulation of carotenoids within lipid-based nanocarriers

(2019) Hadis Rostamabadi et al.   JOURNAL OF CONTROLLED RELEASE

Crocin inhibits the migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells via miR-320/KLF5/HIF-1α signaling

(2019) Ying Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Controlling metastatic cancer: the role of phytochemicals in cell signaling

(2019) Andrea Kapinova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Astaxanthin Combine With Human Serum Albumin To Abrogate Cell Proliferation, Migration, And Drug-Resistant In Human Ovarian Carcinoma SKOV3 Cells

(2019) Xiu-Zhen Su et al.   Anti-Cancer Agents in Medicinal Chemistry

Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro

(2019) Kubatka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

(2019) Marek Samec et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Long‐term efficacy and safety of bexarotene for Japanese patients with cutaneous T‐cell lymphoma: The results of a phase 2 study (B‐1201)

(2019) Toshihisa Hamada et al.   JOURNAL OF DERMATOLOGY

All-trans-retinoic acid (ATRA) plus oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) versus FOLFOX alone as palliative chemotherapy in patients with advanced hepatocellular carcinoma and extrahepatic metastasis: study protocol for a randomized controlled trial

(2019) Jie Shi et al.   Trials

The promotion of nanoparticle delivery to two populations of gastric cancer stem cells by CD133 and CD44 antibodies

(2019) Han Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity: Molecular Evidence

(2019) Sukant Garg et al.   Marine Drugs

Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a

(2019) Hye-Youn Kim et al.   Scientific Reports

β-Cryptoxanthin induced anti-proliferation and apoptosis by G0/G1 arrest and AMPK signal inactivation in gastric cancer

(2019) Meili Gao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Carotenoid-loaded nanocarriers: A comprehensive review

(2019) Abdur Rehman et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Metabolic engineering probiotic yeast produces 3S, 3′S-astaxanthin to inhibit B16F10 metastasis

(2019) Chung-Chih Tseng et al.   FOOD AND CHEMICAL TOXICOLOGY

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

(2019) Shehua Qian et al.   EPMA Journal

Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis

(2019) Shenghui Wu et al.   Advances in Nutrition

Epithelial Mesenchymal Transition in Tumor Metastasis

(2018) Vivek Mittal   Annual Review of Pathology-Mechanisms of Disease

Carotenoids in human nutrition and health

(2018) Manfred Eggersdorfer et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Discovering alkylamide derivatives of bexarotene as new therapeutic agents against triple-negative breast cancer

(2018) Luxi Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Comparative Study on Anti-Invasion, Antimigration, and Antiadhesion Effects of the Bioactive Carotenoids of Saffron on 4T1 Breast Cancer Cells Through Their Effects on Wnt/β-Catenin Pathway Genes

(2018) Laleh Arzi et al.   DNA AND CELL BIOLOGY

The retinamide VNLG-152 inhibits f-AR/AR-V7 and MNK-eIF4E signaling pathways to suppress EMT and castration-resistant prostate cancer xenograft growth

(2018) Vidya P. Ramamurthy et al.   FEBS Journal

Properties of encapsulated saffron extracts in maltodextrin using the Büchi B-90 nano spray-dryer

(2018) Anastasia Kyriakoudi et al.   FOOD CHEMISTRY

Lutein inhibits proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1

(2018) Yuan Li et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Apo-10’-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor γ

(2018) Junrui Cheng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

β-Carotene Supplementation and Lung Cancer Incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: The Role of Tar and Nicotine

(2018) Pooja Middha et al.   NICOTINE & TOBACCO RESEARCH

Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL-6-stimulated liver cancer cells

(2018) Buyun� Kim et al.   ONCOLOGY REPORTS

Glycine and succinic acid are effective indicators of the suppression of epithelial-mesenchymal transition by fucoxanthinol in colorectal cancer stem-like cells

(2018) Masaru Terasaki et al.   ONCOLOGY REPORTS

β‑carotene reverses tobacco smoke‑induced gastric EMT via Notch pathway in vivo

(2018) Ling Lu et al.   ONCOLOGY REPORTS

Fenretinide inhibits the proliferation and migration of human liver cancer HepG2 cells by downregulating the activation of myosin light chain kinase through the p38‑MAPK signaling pathway

(2018) Ling Zhang et al.   ONCOLOGY REPORTS

Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women

(2018) Lu Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cancer Nanotechnology: A New Revolution for Cancer Diagnosis and Therapy

(2018) Vivek K Chaturvedi et al.   CURRENT DRUG METABOLISM

All-trans-retinoic acid activates the pro-invasive Src-YAP-Interleukin 6 axis in triple-negative MDA-MB-231 breast cancer cells while cerivastatin reverses this action

(2018) Belén Mezquita et al.   Scientific Reports

All-Trans Retinoic Acid Enhances Matrix Metalloproteinase 2 Expression and Secretion in Human Myeloid Leukemia THP-1 Cells

(2018) Hien Thi Vu et al.   Biomed Research International

Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention

(2018) A. Kapinova et al.   Environmental Health and Preventive Medicine

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

(2018) Yun Zhang et al.   Frontiers of Medicine

“Dry mouth” and “Flammer” syndromes—neglected risks in adolescents and new concepts by predictive, preventive and personalised approach

(2018) Analtoly Kunin et al.   EPMA Journal

Protective effect of lycopene against chemical and natural toxins: A review

(2018) Narges Hedayati et al.   BIOFACTORS

All-trans retinoic acid reverses epithelial-mesenchymal transition in paclitaxel-resistant cells by inhibiting nuclear factor kappa B and upregulating gap junctions

(2018) Guiling Shi et al.   CANCER SCIENCE

Immune regulation of metastasis: mechanistic insights and therapeutic opportunities

(2018) Olga S. Blomberg et al.   Disease Models & Mechanisms

Inhibitory Effect of Crocin on Metastasis of Triple-Negative Breast Cancer by Interfering with Wnt/β-Catenin Pathway in Murine Model

(2018) Laleh Arzi et al.   DNA AND CELL BIOLOGY

Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis

(2018) Sunny Trivedi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lycopene Inhibits Metastasis of Human Liver Adenocarcinoma SK-Hep-1 Cells by Downregulation of NADPH Oxidase 4 Protein Expression

(2017) Bo-Yi Jhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

(2017) Tong Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epigenetic determinants of metastasis

(2017) Saroor A. Patel et al.   Molecular Oncology

Antioxidants in the Treatment of Cancer

(2017) Kanthi Athreya et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

All-Trans Retinoic Acid Prevents Osteosarcoma Metastasis by Inhibiting M2 Polarization of Tumor-Associated Macrophages

(2017) Qian Zhou et al.   Cancer Immunology Research

Cancer Screening and Early Detection in the 21 st Century

(2017) Jennifer T. Loud et al.   Seminars in Oncology Nursing

Carotenoids: biochemistry, pharmacology and treatment

(2016) Alireza Milani et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model

(2016) Peter Kubatka et al.   EUROPEAN JOURNAL OF NUTRITION

Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles

(2016) Rkia El-Kharrag et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells

(2016) Yugang Liu et al.   NEUROCHEMICAL RESEARCH

All-Trans Retinoic Acid Inhibits Human Colorectal Cancer Cells RKO Migration via Downregulating Myosin Light Chain Kinase Expression through MAPK Signaling Pathway

(2016) Li Zuo et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Nonlethal Levels of Zeaxanthin Inhibit Cell Migration, Invasion, and Secretion of MMP-2 via NF-κB Pathway in Cultured Human Uveal Melanoma Cells

(2016) Ming-Chao Bi et al.   Journal of Ophthalmology

Cancer Chemoprevention by Natural Carotenoids as an Efficient Strategy

(2015) Azam Bolhassani   Anti-Cancer Agents in Medicinal Chemistry

Serum Retinol and Carotenoid Concentrations and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial

(2015) S. H. Nash et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Potential Anti-cancer Drugs Commonly Used for Other Indications

(2015) Veronika Hanusova et al.   CURRENT CANCER DRUG TARGETS

Inflammation Fuels Tumor Progress and Metastasis

(2015) Jingyi Liu et al.   CURRENT PHARMACEUTICAL DESIGN

UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1

(2015) H.-J. Choi et al.   EMBO REPORTS

Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer

(2015) Peter Kubatka et al.   EUROPEAN JOURNAL OF NUTRITION

Carotenoids from fruits and vegetables: Chemistry, analysis, occurrence, bioavailability and biological activities

(2015) Ramesh Kumar Saini et al.   FOOD RESEARCH INTERNATIONAL

MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4

(2015) Jun-Nian Zhou et al.   HEPATOLOGY

Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene

(2015) Bing-Huei Chen et al.   International Journal of Nanomedicine

All-trans retinoic acid inhibits proliferation, migration, invasion and induces differentiation of hepa1-6 cells through reversing EMT in vitro

(2015) JIEJIE CUI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice

(2015) Yi-Zhen Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Retinoic acid receptors: From molecular mechanisms to cancer therapy

(2015) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

Combination chemotherapy of doxorubicin, all-trans retinoic acid and low molecular weight heparin based on self-assembled multi-functional polymeric nanoparticles

(2015) Ting Zhang et al.   NANOTECHNOLOGY

Lycopene Enriched Tomato Extract Inhibits Hypoxia, Angiogenesis, and Metastatic Markers in early Stage N-Nitrosodiethylamine Induced Hepatocellular Carcinoma

(2015) Nisha Bhatia et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition

(2015) Hanbing An et al.   Oncotarget

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells

(2015) Dimitra Bourboulia et al.   Oncotarget

iPS cells: a game changer for future medicine

(2014) H. Inoue et al.   EMBO JOURNAL

β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α

(2014) Yoo-Sun Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

(2014) Sandra S. McAllister et al.   NATURE CELL BIOLOGY

Potential Role of Carotenoids as Antioxidants in Human Health and Disease

(2014) Joanna Fiedor et al.   Nutrients

Dietary and Serum Lycopene Levels in Prostate Cancer Patients Undergoing Intensity-Modulated Radiation Therapy

(2013) Mridul Datta et al.   JOURNAL OF MEDICINAL FOOD

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

A novel hybrid delivery system: Polymer-oil nanostructured carrier for controlled delivery of highly lipophilic drug all-trans-retinoic acid (ATRA)

(2012) Mayuri Narvekar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cancer Chemoprevention by Carotenoids

(2012) Takuji Tanaka et al.   MOLECULES

Combination of paclitaxel- and retinoic acid-incorporated nanoparticles for the treatment of CT-26 colon carcinoma

(2011) Gun-Young Hong et al.   ARCHIVES OF PHARMACAL RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Carotenoids bioavailability from foods: From plant pigments to efficient biological activities

(2011) Elisabet Fernández-García et al.   FOOD RESEARCH INTERNATIONAL

Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1

(2011) Momoko Maekawa et al.   NATURE

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

(2010) J. E. Talmadge et al.   CANCER RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Growth Factors in Induction of Epithelial-Mesenchymal Transition and Metastasis

(2010) Nur Akmarina B.M. Said et al.   CELLS TISSUES ORGANS

A pilot phase II trial of all-trans retinoic acid (Vesanoid) and paclitaxel (Taxol) in patients with recurrent or metastatic breast cancer

(2010) Margarette Bryan et al.   INVESTIGATIONAL NEW DRUGS

Lycopene: features and potential significance in the oral cancer and precancerous lesions

(2010) Rui Lu et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis

(2010) A K Mitra et al.   ONCOGENE

miRNA control of tumor cell invasion and metastasis

(2009) Somesh Baranwal et al.   INTERNATIONAL JOURNAL OF CANCER

Phase II trial of fenretinide (NSC 374551) in patients with recurrent small cell lung cancer

(2009) Bryan J. Schneider et al.   INVESTIGATIONAL NEW DRUGS

Investigating the biomarker potential of glycoproteins using comparative glycoprofiling — application to tissue inhibitor of metalloproteinases-1

(2008) Morten Thaysen-Andersen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A phase I/II trial of TAC-101, an oral synthetic retinoid, in patients with advanced hepatocellular carcinoma

(2008) Kimberly B. Higginbotham et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A microRNA DNA methylation signature for human cancer metastasis

(2008) A. Lujambio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA