New Insights into the Role of the Complement System in Human Viral Diseases

C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus

(2021) Praveen M. Varghese et al.   Frontiers in Immunology

Complement-5 inhibition deters progression of fulminant hepatitis to acute liver failure in murine models

(2021) Jiro Kusakabe et al.   Cellular and Molecular Gastroenterology and Hepatology

Incorporation of CD55 into the Zika Viral Envelope Contributes to Its Stability against Human Complement

(2021) Zahra Malekshahi et al.   Viruses-Basel

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

(2021) Lina Ma et al.   Science Immunology

Multiple-Organ Complement Deposition on Vascular Endothelium in COVID-19 Patients

(2021) Paolo Macor et al.   Biomedicines

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Ebola virus disease

(2020) Shevin T. Jacob et al.   Nature Reviews Disease Primers

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Lower level of complement component C3 and C3a in the plasma means poor outcome in the patients with hepatitis B virus related acute-on-chronic liver failure

(2020) Qian Li et al.   BMC GASTROENTEROLOGY

Complement activation in patients with COVID-19: A novel therapeutic target

(2020) Massimo Cugno et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

(2020) Cynthia Magro et al.   Translational Research

Complement-Independent Modulation of Influenza A Virus Infection by Factor H

(2020) Valarmathy Murugaiah et al.   Frontiers in Immunology

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

(2020) Julien Carvelli et al.   NATURE

Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics

(2020) Jack Mellors et al.   Frontiers in Immunology

Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

(2020) Jan C. Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement protein levels and MBL2 polymorphisms are associated with dengue and disease severity

(2020) Ngo Truong Giang et al.   Scientific Reports

A complement component C1q-mediated mechanism of antibody-dependent enhancement of Ebola virus infection

(2020) Wakako Furuyama et al.   PLoS Neglected Tropical Diseases

In the Crosshairs: RNA Viruses OR Complement?

(2020) Nisha Asok Kumar et al.   Frontiers in Immunology

The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury

(2020) Mineia Alessandra Scaranello Malaquias et al.   Translational Research

From SARS to MERS, Thrusting Coronaviruses into the Spotlight

(2019) Zhiqi Song et al.   Viruses-Basel

Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV

(2019) Yuting Jiang et al.   Viruses-Basel

Zika Virus: Origins, Pathological Action, and Treatment Strategies

(2019) Kirill Gorshkov et al.   Frontiers in Microbiology

Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

(2019) Katharina Bröker et al.   Journal of Translational Medicine

Acute Respiratory Distress Syndrome: Etiology, Pathogenesis, and Summary on Management

(2019) Shawn Kaku et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Acute liver failure

(2019) R Todd Stravitz et al.   LANCET

Alternative pathway of complement activation has a beneficial role against Chandipura virus infection

(2019) Pooja Gupta et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

(2019) Claudia P. Figueiredo et al.   Nature Communications

C5a receptor1 inhibition alleviates influenza virus-induced acute lung injury

(2018) Nianping Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dengue Virus Induces Increased Activity of the Complement Alternative Pathway in Infected Cells

(2018) Sheila Cabezas et al.   JOURNAL OF VIROLOGY

Identification of key candidate genes and pathways in hepatitis B virus-associated acute liver failure by bioinformatical analysis

(2018) Huapeng Lin et al.   MEDICINE

Zika virus infection elicits auto-antibodies to C1q

(2018) Takaaki Koma et al.   Scientific Reports

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

(2018) Yuting Jiang et al.   Emerging Microbes & Infections

Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies

(2018) Chrysoula Papageorgiou et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure

(2018) Zhaochun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex

(2018) Britta Schiela et al.   Frontiers in Immunology

A C3(H20) recycling pathway is a component of the intracellular complement system

(2017) Michelle Elvington et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4

(2017) HongBin Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergy between the classical and alternative pathways of complement is essential for conferring effective protection against the pandemic influenza A(H1N1) 2009 virus infection

(2017) Ajitanuj Rattan et al.   PLoS Pathogens

C5L2, the Second C5a Anaphylatoxin Receptor, Suppresses LPS-Induced Acute Lung Injury

(2016) Ruobing Wang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Secreted NS1 Protects Dengue Virus from Mannose-Binding Lectin–Mediated Neutralization

(2016) Somchai Thiemmeca et al.   JOURNAL OF IMMUNOLOGY

Complement Opsonization Promotes Herpes Simplex Virus 2 Infection of Human Dendritic Cells

(2016) Elisa Crisci et al.   JOURNAL OF VIROLOGY

Inhibition of the Membrane Attack Complex by Dengue Virus NS1 through Interaction with Vitronectin and Terminal Complement Proteins

(2016) Jonas Nascimento Conde et al.   JOURNAL OF VIROLOGY

Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI)

(2016) Miriam Kalbitz et al.   PLoS One

C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure

(2016) Yan-Chang Lei et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatitis B virus X protein up-regulates C4b-binding protein α through activating transcription factor Sp1 in protection of hepatoma cells from complement attack

(2016) Guoxing Feng et al.   Oncotarget

Molecules Great and Small: The Complement System

(2015) D. R. Mathern et al.   Clinical Journal of the American Society of Nephrology

Influenza virus-induced lung injury: pathogenesis and implications for treatment

(2015) Susanne Herold et al.   EUROPEAN RESPIRATORY JOURNAL

Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin

(2015) Norman F. Russkamp et al.   FASEB JOURNAL

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection

(2015) Xinyi Tu et al.   JOURNAL OF INFECTION

Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection

(2015) Yung-Chun Chuang et al.   MEDIATORS OF INFLAMMATION

Complement-Coagulation Cross-Talk: A Potential Mediator of the Physiological Activation of Complement by Low pH

(2015) Hany Ibrahim Kenawy et al.   Frontiers in Immunology

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Caring for Critically Ill Patients with Ebola Virus Disease. Perspectives from West Africa

(2014) Robert A. Fowler et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Severe acute respiratory syndrome vs. the Middle East respiratory syndrome

(2014) David S. Hui et al.   CURRENT OPINION IN PULMONARY MEDICINE

Pathologic highlights of dengue hemorrhagic fever in 13 autopsy cases from Myanmar

(2014) Khin Saw Aye et al.   HUMAN PATHOLOGY

Clinical features and pathobiology of Ebolavirus infection

(2014) Aftab A. Ansari   JOURNAL OF AUTOIMMUNITY

Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection

(2014) J. R. Teijaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular sensing of complement C3 activates cell autonomous immunity

(2014) J. C. H. Tam et al.   SCIENCE

Inhibition of Complement Activation Alleviates Acute Lung Injury Induced by Highly Pathogenic Avian Influenza H5N1 Virus Infection

(2013) Shihui Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

(2013) Markus Bosmann et al.   FASEB JOURNAL

Hepatitis B virus core protein interacts with CD59 to promote complement-mediated liver inflammation during chronic hepatitis B virus infection

(2013) Dong Liu et al.   FEBS LETTERS

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

Disruption of the Complement Anaphylatoxin Receptor C5L2 Exacerbates Inflammation in Allergic Contact Dermatitis

(2013) R. Wang et al.   JOURNAL OF IMMUNOLOGY

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

(2013) Jie Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

(2013) Abdullah Assiri et al.   LANCET INFECTIOUS DISEASES

Pathogenesis of influenza-induced acute respiratory distress syndrome

(2013) Kirsty R Short et al.   LANCET INFECTIOUS DISEASES

Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation

(2013) Arije Ghannam et al.   MOLECULAR IMMUNOLOGY

Complement C5 Activation during Influenza A Infection in Mice Contributes to Neutrophil Recruitment and Lung Injury

(2013) Cristiana C. Garcia et al.   PLoS One

Lectin-Dependent Enhancement of Ebola Virus Infection via Soluble and Transmembrane C-type Lectin Receptors

(2013) Matthew Brudner et al.   PLoS One

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus

(2013) L. Josset et al.   mBio

West Nile Virus: Biology, Transmission, and Human Infection

(2012) T. M. Colpitts et al.   CLINICAL MICROBIOLOGY REVIEWS

Acute Respiratory Distress Syndrome

(2012)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Complement Activation Product C5a Is a Selective Suppressor of TLR4-Induced, but Not TLR3-Induced, Production of IL-27(p28) from Macrophages

(2012) M. Bosmann et al.   JOURNAL OF IMMUNOLOGY

Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells

(2012) Michael G Strainic et al.   NATURE IMMUNOLOGY

Macrophages and Tissue Injury: Agents of Defense or Destruction?

(2011) Debra L. Laskin et al.   Annual Review of Pharmacology and Toxicology

Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cells from complement attack

(2011) Changliang Shan et al.   CARCINOGENESIS

Th17 Cytokines Are Critical for Respiratory Syncytial Virus-Associated Airway Hyperreponsiveness through Regulation by Complement C3a and Tachykinins

(2011) Monali M. Bera et al.   JOURNAL OF IMMUNOLOGY

Binding of Flavivirus Nonstructural Protein NS1 to C4b Binding Protein Modulates Complement Activation

(2011) P. Avirutnan et al.   JOURNAL OF IMMUNOLOGY

Structural basis for engagement by complement factor H of C3b on a self surface

(2011) Hugh P Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Protective Role for Complement C3 Protein during Pandemic 2009 H1N1 and H5N1 Influenza A Virus Infection

(2011) Kevin B. O'Brien et al.   PLoS One

Complement and the Alternative Pathway Play an Important Role in LPS/D-GalN-Induced Fulminant Hepatic Failure

(2011) Shihui Sun et al.   PLoS One

Thrombomodulin and its role in inflammation

(2011) Edward M. Conway   Seminars in Immunopathology

Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin

(2011) P. Avirutnan et al.   mBio

Direct Complement Restriction of Flavivirus Infection Requires Glycan Recognition by Mannose-Binding Lectin

(2010) Anja Fuchs et al.   Cell Host & Microbe

Antibody-directed complement-mediated cytotoxicity to hepatocytes from patients with chronic hepatitis B

(2010) T. I. MICHALAK et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A Novel L-ficolin/Mannose-binding Lectin Chimeric Molecule with Enhanced Activity against Ebola Virus

(2010) Ian C. Michelow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antagonism of the complement component C4 by flavivirus nonstructural protein NS1

(2010) Panisadee Avirutnan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae

(2010) S. Agarwal et al.   JOURNAL OF IMMUNOLOGY

High-Dose Mannose-Binding Lectin Therapy for Ebola Virus Infection

(2010) Ian C. Michelow et al.   JOURNAL OF INFECTIOUS DISEASES

Acute liver failure: mechanisms of immune-mediated liver injury

(2010) Zeguang Wu et al.   LIVER INTERNATIONAL

Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4- and IFN-β-dependent

(2010) K A Shirey et al.   Mucosal Immunology

Steric Shielding of Surface Epitopes and Impaired Immune Recognition Induced by the Ebola Virus Glycoprotein

(2010) Joseph R. Francica et al.   PLoS Pathogens

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Complement: coming full circle

(2009) Gaëlle Le Friec et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Complement and its role in innate and adaptive immune responses

(2009) Jason R Dunkelberger et al.   CELL RESEARCH

Dengue Virus Pathogenesis: an Integrated View

(2009) B. E. E. Martina et al.   CLINICAL MICROBIOLOGY REVIEWS

Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection

(2009) Iranaia Assunção-Miranda et al.   FASEB JOURNAL

Paths reunited: Initiation of the classical and lectin pathways of complement activation

(2009) Russell Wallis et al.   IMMUNOBIOLOGY

Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA

(2009) J. Zhang et al.   JOURNAL OF GENERAL VIROLOGY

Ebolavirus Glycoprotein GP Masks both Its Own Epitopes and the Presence of Cellular Surface Proteins

(2009) O. Reynard et al.   JOURNAL OF VIROLOGY

Hepatitis B virus sensitizes hepatocytes to complement-dependent cytotoxicity through downregulating CD59

(2009) Zhonghua Qu et al.   MOLECULAR IMMUNOLOGY

Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity

(2009) Eduardo J. M. Nascimento et al.   PLoS One

Animal models of acute lung injury

(2008) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Properdin and Complement Activation: A Fresh Perspective

(2008) Dennis Hourcade   CURRENT DRUG TARGETS

Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells

(2008) Michael G. Strainic et al.   IMMUNITY

The alternative complement pathway revisited

(2008) Morten Harboe et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Biological activities of C1 inhibitor

(2008) Alvin E. Davis et al.   MOLECULAR IMMUNOLOGY

Differential mechanisms of complement-mediated neutralization of the closely related paramyxoviruses simian virus 5 and mumps virus

(2008) John B. Johnson et al.   VIROLOGY

Cellular Proteins in Influenza Virus Particles

(2008) Megan L. Shaw et al.   PLoS Pathogens