The TNF-α/TNFR2 Pathway: Targeting a Brake to Release the Anti-tumor Immune Response

Co-Expression of Membrane-Bound Tumor Necrosis Factor-Alpha Receptor Types 1 and 2 by Tumor Cell Lines

(2020) Alina A. Alshevskaya et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach

(2020) Roman Fischer et al.   Frontiers in Cell and Developmental Biology

The TNF/TNFR2 signaling pathway is a key regulatory factor in endothelial progenitor cell immunosuppressive effect

(2020) Sina Naserian et al.   Cell Communication and Signaling

TNFα-TNFR2 signaling pathway in control of the neural stem/progenitor cell immunosuppressive effect: Different experimental approaches to assess this hypothetical mechanism behind their immunological function

(2020) Sara Shamdani et al.   Stem Cell Research & Therapy

TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function

(2020) Ghada Beldi et al.   Stem Cell Research & Therapy

CD4+CD25highCD127low/-FoxP3+ Regulatory T-Cell Population in Acute Leukemias: A Review of the Literature

(2019) M. Niedźwiecki et al.   Journal of Immunology Research

Targeting TNFR2 as a Novel Therapeutic Strategy for Alzheimer’s Disease

(2019) Natalia Ortí-Casañ et al.   Frontiers in Neuroscience

Rational design of anti-GITR-based combination immunotherapy

(2019) Roberta Zappasodi et al.   NATURE MEDICINE

GITR agonism — combination is key

(2019) David Killock   Nature Reviews Clinical Oncology

Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis

(2019) Roman Fischer et al.   BRAIN BEHAVIOR AND IMMUNITY

The TNF Paradox in Cancer Progression and Immunotherapy

(2019) Anne Montfort et al.   Frontiers in Immunology

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages

(2019) Harald Wajant et al.   Frontiers in Cell and Developmental Biology

TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes

(2019) Roman Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Regulatory T Cells by Addressing Tumor Necrosis Factor and Its Receptors in Allogeneic Hematopoietic Cell Transplantation and Cancer

(2019) Harald Wajant et al.   Frontiers in Immunology

Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity

(2019) Eric M. Tam et al.   Science Translational Medicine

Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein

(2019) Tanja Padutsch et al.   Frontiers in Pharmacology

Signaling and Function of Interleukin-2 in T Lymphocytes

(2018) Sarah H. Ross et al.   Annual Review of Immunology

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling

(2018) Alice Borghi et al.   BIOCHEMICAL PHARMACOLOGY

Immune regulation by CD8+ Treg cells: novel possibilities for anticancer immunotherapy

(2018) Shuping Zhang et al.   Cellular & Molecular Immunology

Intracellular regulation of TNF activity in health and disease

(2018) Eugene Varfolomeev et al.   CYTOKINE

TNF activity and T cells

(2018) Amit K. Mehta et al.   CYTOKINE

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer

(2018) Yingjie Nie et al.   Science Signaling

Clinical significance of tumor necrosis factor receptor 2 in middle and lower thoracic esophageal squamous cell carcinoma

(2018) Dong Yang et al.   Oncology Letters

Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?

(2018) Fei Tang et al.   Cell and Bioscience

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer

(2018) Yingjie Nie et al.   Science Signaling

Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis

(2018) Roman Fischer et al.   Arthritis & Rheumatology

Selective Modulation of TNF–TNFRs Signaling: Insights for Multiple Sclerosis Treatment

(2018) Valentina Pegoretti et al.   Frontiers in Immunology

The p38 MAPK Inhibitor SB203580 Abrogates Tumor Necrosis Factor-Induced Proliferative Expansion of Mouse CD4+Foxp3+ Regulatory T Cells

(2018) Tianzhen He et al.   Frontiers in Immunology

Tumor Necrosis Factor α and Regulatory T Cells in Oncoimmunology

(2018) Benoît L. Salomon et al.   Frontiers in Immunology

TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors

(2018) Yuqiao Sheng et al.   Frontiers in Immunology

Increased Regulatory T Cells in Peripheral Blood of Acute Myeloid Leukemia Patients Rely on Tumor Necrosis Factor (TNF)-α–TNF Receptor-2 Pathway

(2018) Min Wang et al.   Frontiers in Immunology

TNF Receptor Type II as an Emerging Drug Target for the Treatment of Cancer, Autoimmune Diseases, and Graft-Versus-Host Disease: Current Perspectives and In Silico Search for Small Molecule Binders

(2018) Faraz Shaikh et al.   Frontiers in Immunology

ICONIC: Biologic and clinical activity of first in class ICOS agonist antibody JTX-2011 +/- nivolumab (nivo) in patients (pts) with advanced cancers.

(2018) Timothy Anthony Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Unleashing endogenous TNF-alpha as a cancer immunotherapeutic

(2018) Steven F. Josephs et al.   Journal of Translational Medicine

Pembrolizumab plus Chemotherapy for Squamous Non–Small-Cell Lung Cancer

(2018) Luis Paz-Ares et al.   NEW ENGLAND JOURNAL OF MEDICINE

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway

(2018) Jun Wang et al.   Scientific Reports

Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome

(2018) H Torrey et al.   LEUKEMIA

Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity

(2018) Kamar-Sulu N. Atretkhany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy

(2018) Arabella Young et al.   Cancer Immunology Research

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer

(2017) Xin Chen et al.   Science Signaling

TNFR2: A Novel Target for Cancer Immunotherapy

(2017) Éva S. Vanamee et al.   TRENDS IN MOLECULAR MEDICINE

Depletion of regulatory T cells by anti-ICOS antibody enhances anti-tumor immunity of tumor cell vaccine in prostate cancer

(2017) Lijun Mo et al.   VACCINE

Aberrant frequency of TNFR2+ Treg and related cytokines in patients with CIN and cervical cancer

(2017) Teng Zhang et al.   Oncotarget

Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2

(2017) Roman Fischer et al.   Scientific Reports

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer

(2017) Xin Chen et al.   Science Signaling

TNFR2: The new Treg switch?

(2017) José L. Cohen et al.   OncoImmunology

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

(2016) M. Leclerc et al.   BLOOD

Soluble tumour necrosis factor receptor type II and survival in colorectal cancer

(2016) Ana Babic et al.   BRITISH JOURNAL OF CANCER

Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy

(2016) K.-S. Le et al.   CANCER RESEARCH

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Epithelial Nuclear Factor-κB Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis

(2016) Takashi Nagaishi et al.   DIGESTION

Rationale for anti-OX40 cancer immunotherapy

(2016) Sandrine Aspeslagh et al.   EUROPEAN JOURNAL OF CANCER

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

(2016) Takuro Saito et al.   NATURE MEDICINE

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

(2016) Danny N. Khalil et al.   Nature Reviews Clinical Oncology

Management of Adverse Events Following Treatment With Anti-Programmed Death-1 Agents

(2016) Jeffrey S. Weber et al.   ONCOLOGIST

Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis

(2016) Daniela Siegmund et al.   Cell Death & Disease

Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma

(2016) Rafia S. Al-Lamki et al.   Oncotarget

Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy

(2016) Geoffrey S. Williams et al.   Oncotarget

A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells

(2016) Xuehui He et al.   PLoS One

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Expression of TNFR2 by regulatory T cells in peripheral blood is correlated with clinical pathology of lung cancer patients

(2015) Fan Yan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages

(2015) C. Frankenberger et al.   CANCER RESEARCH

TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases

(2015) B. Ham et al.   CANCER RESEARCH

Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8+ T Cells in Mice With Colitis

(2015) Shivesh Punit et al.   GASTROENTEROLOGY

Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2

(2015) Alexander Ungewickell et al.   NATURE GENETICS

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

(2015) Bin Shang et al.   Scientific Reports

Blockade of TNF-α signaling benefits cancer therapy by suppressing effector regulatory T cell expansion

(2015) Li-Yuan Chang et al.   OncoImmunology

Systemic use of tumor necrosis factor alpha as an anticancer agent

(2015) Nicholas J. Roberts et al.   Oncotarget

Lenalidomide-based maintenance therapy reduces TNF receptor 2 on CD4 T cells and enhances immune effector function in acute myeloid leukemia patients

(2014) Chindu Govindaraj et al.   AMERICAN JOURNAL OF HEMATOLOGY

Expression of tumour necrosis factor-α and its receptors in Hodgkin lymphoma

(2014) Shoko Nakayama et al.   BRITISH JOURNAL OF HAEMATOLOGY

Reduction of Regulatory T Cells by Mogamulizumab, a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients with Aggressive/Refractory Mycosis Fungoides and Sezary Syndrome

(2014) X. Ni et al.   CLINICAL CANCER RESEARCH

TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future

(2014) Lisa M. Sedger et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Regulation and dysregulation of tumor necrosis factor receptor-1

(2014) Leen Puimège et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cutting Edge: TNFR-Shedding by CD4+CD25+ Regulatory T Cells Inhibits the Induction of Inflammatory Mediators

(2014) G. J. D. van Mierlo et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell Maturation and Survival Are Differentially Regulated by TNFR1 and TNFR2

(2014) Nicola J. Maney et al.   JOURNAL OF IMMUNOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Myosin Light Chain Kinase Expression Induced via Tumor Necrosis Factor Receptor 2 Signaling in the Epithelial Cells Regulates the Development of Colitis-Associated Carcinogenesis

(2014) Masahiro Suzuki et al.   PLoS One

Rapid Rebound of the Treg Compartment in DEREG Mice Limits the Impact of Treg Depletion on Mycobacterial Burden, but Prevents Autoimmunity

(2014) Luciana Berod et al.   PLoS One

Associations between functional TNFR2 196 M/R polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis

(2014) Gwan Gyu Song et al.   RHEUMATOLOGY INTERNATIONAL

Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis

(2013) Martin Chopra et al.   CARCINOGENESIS

Reducing TNF Receptor 2 + Regulatory T Cells via the Combined Action of Azacitidine and the HDAC Inhibitor, Panobinostat for Clinical Benefit in Acute Myeloid Leukemia Patients

(2013) Chindu Govindaraj et al.   CLINICAL CANCER RESEARCH

Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2+ Tregs within the tumor microenvironment

(2013) Chindu Govindaraj et al.   CLINICAL IMMUNOLOGY

Therapeutic polyclonal human CD8+ CD25+ Fox3+ TNFR2+ PD-L1+ regulatory cells induced ex-vivo

(2013) David A. Horwitz et al.   CLINICAL IMMUNOLOGY

Prognostic value of regulatory T cells in newly diagnosed chronic myeloid leukemia patients

(2013) Asmaa M. Zahran et al.   International Journal of Clinical Oncology

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Transmembrane TNF-  Promotes Suppressive Activities of Myeloid-Derived Suppressor Cells via TNFR2

(2013) X. Hu et al.   JOURNAL OF IMMUNOLOGY

Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2

(2013) Yoshiaki Okubo et al.   Scientific Reports

TNFR2 Expression on CD25hiFOXP3+ T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors

(2013) Chindu Govindaraj et al.   Frontiers in Immunology

TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine

(2013) Denise L. Faustman et al.   Frontiers in Immunology

Tumour-infiltrating FOXP3+ lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer

(2012) N R West et al.   BRITISH JOURNAL OF CANCER

TNF signaling drives myeloid-derived suppressor cell accumulation

(2012) Xueqiang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study

(2012) Takashi Ishida et al.   JOURNAL OF CLINICAL ONCOLOGY

Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival

(2012) Steffen Walter et al.   NATURE MEDICINE

What are regulatory T cells (Treg) regulating in cancer and why?

(2012) Theresa L. Whiteside   SEMINARS IN CANCER BIOLOGY

T-cell-mediated immunological barriers to xenotransplantation

(2012) Joseph Scalea et al.   XENOTRANSPLANTATION

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications

(2011) E. Campo et al.   BLOOD

Heterogeneity reduces sensitivity of cell death for TNF-Stimuli

(2011) Monica Schliemann et al.   BMC Systems Biology

Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity

(2011) Xin Chen et al.   FEBS LETTERS

The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4+ FoxP3+ regulatory T cells

(2011) Xin Chen et al.   IMMUNOLOGY

Resolving the identity myth: Key markers of functional CD4+FoxP3+ regulatory T cells

(2011) Xin Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Natural but Not Inducible Regulatory T Cells Require TNF-  Signaling for In Vivo Function

(2011) W. J. Housley et al.   JOURNAL OF IMMUNOLOGY

Cytokine Induction of Tumor Necrosis Factor Receptor 2 Is Mediated by STAT3 in Colon Cancer Cells

(2011) K. E. Hamilton et al.   MOLECULAR CANCER RESEARCH

Breaking the ‘harmony’ of TNF-α signaling for cancer treatment

(2011) S P Sasi et al.   ONCOGENE

A TNF Receptor 2 Selective Agonist Rescues Human Neurons from Oxidative Stress-Induced Cell Death

(2011) Roman Fischer et al.   PLoS One

TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms

(2011) H Rauert et al.   Cell Death & Disease

Selective Depletion of Foxp3+ Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma

(2010) K. Klages et al.   CANCER RESEARCH

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Acquisition of regulatory function by human CD8+ T cells treated with anti-CD3 antibody requires TNF

(2010) Vitaly Ablamunits et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells

(2010) Yuh-Ching Twu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3- Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

(2010) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells

(2010) F. S. Kleijwegt et al.   JOURNAL OF IMMUNOLOGY

Regulatory (FoxP3+) T-cell Tumor Infiltration Is a Favorable Prognostic Factor in Advanced Colon Cancer Patients Undergoing Chemo or Chemoimmunotherapy

(2010) Pierpaolo Correale et al.   JOURNAL OF IMMUNOTHERAPY

Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease

(2010) Giovanni D’Arena et al.   LEUKEMIA RESEARCH

TNF receptor 2 pathway: drug target for autoimmune diseases

(2010) Denise Faustman et al.   NATURE REVIEWS DRUG DISCOVERY

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Solution of the Structure of the TNF-TNFR2 Complex

(2010) Y. Mukai et al.   Science Signaling

Tumor necrosis factor and cancer, buddies or foes?

(2009) Xia Wang et al.   ACTA PHARMACOLOGICA SINICA

Signaling pathway via TNF-α/NF-κB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis

(2009) Michio Onizawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis

(2009) Elias Gounaris et al.   CANCER RESEARCH

Increased Frequency and Suppression by Regulatory T Cells in Patients with Acute Myelogenous Leukemia

(2009) M. J. Szczepanski et al.   CLINICAL CANCER RESEARCH

Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma

(2009) Frank A. Sinicrope et al.   GASTROENTEROLOGY

High frequency of tumor-infiltrating FOXP3+regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients

(2009) Daniel M. Frey et al.   INTERNATIONAL JOURNAL OF CANCER

Cutting Edge: Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice

(2009) J. Kim et al.   JOURNAL OF IMMUNOLOGY

TNFR2-Deficient Memory CD8 T Cells Provide Superior Protection against Tumor Cell Growth

(2009) E. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma

(2008) S. Mittal et al.   BLOOD

Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy

(2008) Robbert G. van der Most et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer

(2008) Ninke Leffers et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Regulatory T cells and treatment of cancer

(2008) Tyler J Curiel   CURRENT OPINION IN IMMUNOLOGY

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

(2008) Paul Salama et al.   JOURNAL OF CLINICAL ONCOLOGY

Transmembrane TNF-α mediates “forward” and “reverse” signaling, inducing cell death or survival via the NF-κB pathway in Raji Burkitt lymphoma cells

(2008) Hailong Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Exogenous tumor necrosis factor-alpha induces suppression of autoimmune arthritis

(2008) Eugene Y Kim et al.   ARTHRITIS RESEARCH & THERAPY