APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells

Apurinic/Apyrimidinic Endonuclease 2 (APE2): An ancillary enzyme for contextual base excision repair mechanisms to preserve genome stability

(2021) Sima Chaudhari et al.   BIOCHIMIE

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Genomic alterations and abnormal expression of APE2 in multiple cancers

(2020) Katherine A. Jensen et al.   Scientific Reports

Topoisomerase II-binding protein 1 promotes the progression of prostate cancer via ATR-CHK1 signaling pathway

(2020) Kaiwen Li et al.   Aging-US

Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease

(2020) Alejandro Álvarez-Quilón et al.   MOLECULAR CELL

Identification of APEX2 as an oncogene in liver cancer

(2020) Ru Zheng et al.   World Journal of Clinical Cases

The multifunctional APE1 DNA repair–redox signaling protein as a drug target in human disease

(2020) Rachel A. Caston et al.   DRUG DISCOVERY TODAY

Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes

(2020) Xihan Guo et al.   INTERNATIONAL JOURNAL OF CANCER

Cisplatin-mediated upregulation of APE2 binding to MYH9 provokes mitochondrial fragmentation and acute kidney injury

(2020) Yi Hu et al.   CANCER RESEARCH

Function and molecular mechanisms of APE2 in genome and epigenome integrity

(2020) Yunfeng Lin et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

(2019) Kristen E. Mengwasser et al.   MOLECULAR CELL

A phase I study of the APE1 protein inhibitor APX3330 in patients with advanced solid tumors.

(2019) Safi Shahda et al.   JOURNAL OF CLINICAL ONCOLOGY

Resolution of a complex crisis at DNA 3′ termini

(2019) Shan Yan   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A consensus set of genetic vulnerabilities to ATR inhibition

(2019) Nicole Hustedt et al.   Open Biology

Distinct roles of XRCC1 in genome integrity in Xenopus egg extracts

(2019) Steven Cupello et al.   BIOCHEMICAL JOURNAL

APE1 senses DNA single-strand breaks for repair and signaling

(2019) Yunfeng Lin et al.   NUCLEIC ACIDS RESEARCH

Targeting ATR as Cancer Therapy: A new era for synthetic lethality and synergistic combinations?

(2019) Alice Bradbury et al.   PHARMACOLOGY & THERAPEUTICS

The ATR Inhibitor AZD6738 Synergizes with GemcitabineIn VitroandIn Vivoto Induce Pancreatic Ductal Adenocarcinoma Regression

(2018) Yann Wallez et al.   MOLECULAR CANCER THERAPEUTICS

APE2 promotes DNA damage response pathway from a single-strand break

(2018) Yunfeng Lin et al.   NUCLEIC ACIDS RESEARCH

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F

(2018) Shao-Ru Chen et al.   Frontiers in Pharmacology

Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2

(2018) Md. Hossain et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance

(2018) Subodh Kumar et al.   Blood Cancer Journal

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

(2018) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-free Xenopus egg extracts for studying DNA damage response pathways

(2016) Steven Cupello et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage

(2016) Julyana Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress

(2016) Bret D. Wallace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts

(2015) Darla DeStephanis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Pathways: Targeting ATR in Cancer Therapy

(2015) L. M. Karnitz et al.   CLINICAL CANCER RESEARCH

Biochemical mechanism of DSB end resection and its regulation

(2015) James M. Daley et al.   DNA REPAIR

Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition

(2015) Venkatasubbaiah A. Venkatesha et al.   NEOPLASIA

Identification of ATR-Chk1 Pathway Inhibitors That Selectively Target p53-Deficient Cells without Directly Suppressing ATR Catalytic Activity

(2014) M. Kawasumi et al.   CANCER RESEARCH

ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses

(2014) R. Josse et al.   CANCER RESEARCH

RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response

(2014) Alexandre Maréchal et al.   CELL RESEARCH

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

(2014) Shan Yan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

End Resection at Double-Strand Breaks: Mechanism and Regulation

(2014) L. S. Symington   Cold Spring Harbor Perspectives in Biology

Over expression of hRad9 protein correlates with reduced chemosensitivity in breast cancer with administration of neoadjuvant chemotherapy

(2014) Haiqin Yun et al.   Scientific Reports

Human Apurinic/Apyrimidinic Endonuclease 1

(2013) Mengxia Li et al.   ANTIOXIDANTS & REDOX SIGNALING

WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling

(2013) Shan Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine

(2013) J. Fredebohm et al.   JOURNAL OF CELL SCIENCE

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress

(2013) J. Willis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

(2012) E Fokas et al.   Cell Death & Disease

Study of the DNA Damage Checkpoint using Xenopus Egg Extracts

(2012) Jeremy Willis et al.   Jove-Journal of Visualized Experiments

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Genetic activities in micronuclei: Is the DNA entrapped in micronuclei lost for the cell?

(2010) Mariona Terradas et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

(2009) Z. Sabouri et al.   INTERNATIONAL IMMUNOLOGY

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks

(2009) Shan Yan et al.   JOURNAL OF CELL BIOLOGY

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage

(2009) P. Burkovics et al.   NUCLEIC ACIDS RESEARCH

Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus

(2008) Yukihiko Dan et al.   DNA REPAIR

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

(2008) T. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY