Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease

Published 2020 View Full Article

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Title
Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease
Authors
Keywords
BRCA1, BRCA2, APE2, APEX2, RNASEH2, synthetic lethality, TOP1, TDP1, ribonucleotide
Journal
MOLECULAR CELL
Volume 78, Issue 6, Pages 1152-1165.e8
Publisher
Elsevier BV
Online
2020-06-08
DOI
10.1016/j.molcel.2020.05.021

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