Function and molecular mechanisms of APE2 in genome and epigenome integrity

Genomic alterations and abnormal expression of APE2 in multiple cancers

(2020) Katherine A. Jensen et al.   Scientific Reports

Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma

(2020) Gökçen Ömeroğlu Şimşek   Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery

Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences

(2020) Maria Stratigopoulou et al.   Frontiers in Immunology

New insights into abasic site repair and tolerance

(2020) Petria S. Thompson et al.   DNA REPAIR

Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease

(2020) Alejandro Álvarez-Quilón et al.   MOLECULAR CELL

Identification of APEX2 as an oncogene in liver cancer

(2020) Ru Zheng et al.   World Journal of Clinical Cases

A non-canonical role for the DNA glycosylase NEIL3 in suppressing APE1 endonuclease-mediated ssDNA damage

(2020) Anh Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apn2 resolves blocked 3′ ends and suppresses Top1-induced mutagenesis at genomic rNMP sites

(2019) Fuyang Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRAIP is a master regulator of DNA interstrand crosslink repair

(2019) R. Alex Wu et al.   NATURE

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

(2019) Kristen E. Mengwasser et al.   MOLECULAR CELL

Resolution of a complex crisis at DNA 3′ termini

(2019) Shan Yan   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A consensus set of genetic vulnerabilities to ATR inhibition

(2019) Nicole Hustedt et al.   Open Biology

Structure and function relationships in mammalian DNA polymerases

(2019) Nicole M. Hoitsma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Distinct roles of XRCC1 in genome integrity in Xenopus egg extracts

(2019) Steven Cupello et al.   BIOCHEMICAL JOURNAL

APE1 senses DNA single-strand breaks for repair and signaling

(2019) Yunfeng Lin et al.   NUCLEIC ACIDS RESEARCH

APE2 promotes DNA damage response pathway from a single-strand break

(2018) Yunfeng Lin et al.   NUCLEIC ACIDS RESEARCH

Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2

(2018) Md. Hossain et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance

(2018) Subodh Kumar et al.   Blood Cancer Journal

Cell-free Xenopus egg extracts for studying DNA damage response pathways

(2016) Steven Cupello et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

APE2 Zf-GRF facilitates 3′-5′ resection of DNA damage following oxidative stress

(2016) Bret D. Wallace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

(2015) Sebastian Eustermann et al.   MOLECULAR CELL

An AP Endonuclease Functions in Active DNA Demethylation and Gene Imprinting in Arabidopsis

(2015) Yan Li et al.   PLoS Genetics

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

(2014) Shan Yan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast

(2014) Jin Jin et al.   DNA REPAIR

Recognition and repair of chemically heterogeneous structures at DNA ends

(2014) Sara N. Andres et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The DNA Repair Enzyme Apurinic/Apyrimidinic Endonuclease (Apex Nuclease) 2 Has the Potential to Protect against Down-Regulation of Chondrocyte Activity in Osteoarthritis

(2014) Naoko Yui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation

(2014) J. Stavnezer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homology-directed repair of DNA nicks via pathways distinct from canonical double-strand break repair

(2014) L. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Apurinic/Apyrimidinic Endonuclease 1

(2013) Mengxia Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Expression, Functionality, and Localization of Apurinic/Apyrimidinic Endonucleases in Replicative and Non-Replicative Forms ofTrypanosoma cruzi

(2013) S. Sepúlveda et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Apurinic/Apyrimidinic Endonuclease 1 Is the Essential Nuclease during Immunoglobulin Class Switch Recombination

(2013) S. Masani et al.   MOLECULAR AND CELLULAR BIOLOGY

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Regulation of PCNA–protein interactions for genome stability

(2013) Niels Mailand et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress

(2013) J. Willis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Apurinic/Apyrimidinic Endonuclease 2 Is Necessary for Normal B Cell Development and Recovery of Lymphoid Progenitors after Chemotherapeutic Challenge

(2011) J. E. J. Guikema et al.   JOURNAL OF IMMUNOLOGY

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage

(2010) David Svilar et al.   ANTIOXIDANTS & REDOX SIGNALING

Hereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2

(2010) Nancie Petrucelli et al.   GENETICS IN MEDICINE

The role of Apex2 in class-switch recombination of immunoglobulin genes

(2010) Jeroen E. J. Guikema et al.   INTERNATIONAL IMMUNOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing

(2010) Wenyi Wang et al.   NUCLEIC ACIDS RESEARCH

Active DNA Demethylation Mediated by DNA Glycosylases

(2009) Jian-Kang Zhu   Annual Review of Genetics

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

(2009) Z. Sabouri et al.   INTERNATIONAL IMMUNOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage

(2009) P. Burkovics et al.   NUCLEIC ACIDS RESEARCH

Requirement for Abasic Endonuclease Gene Homologues in Arabidopsis Seed Development

(2009) Terence M. Murphy et al.   PLoS One

The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme

(2008) Gianluca Tell et al.   ANTIOXIDANTS & REDOX SIGNALING

Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

(2008) Muralidhar L Hegde et al.   CELL RESEARCH

Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus

(2008) Yukihiko Dan et al.   DNA REPAIR

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

(2008) Mansour Akbari et al.   DNA REPAIR

Single-strand break repair and genetic disease

(2008) Keith W. Caldecott   NATURE REVIEWS GENETICS

DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining

(2008) S. Malyarchuk et al.   NUCLEIC ACIDS RESEARCH

The roles of APE1, APE2, DNA polymerase   and mismatch repair in creating S region DNA breaks during antibody class switch

(2008) C. E Schrader et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES