CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE

Effect of CD47 Blockade on Vascular Inflammation

(2021) Kai-Uwe Jarr et al.   NEW ENGLAND JOURNAL OF MEDICINE

The CD47-SIRPα Immune Checkpoint

(2020) Meike E.W. Logtenberg et al.   IMMUNITY

Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo

(2020) Veronica Azcutia et al.   Mucosal Immunology

Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation

(2020) Rasmus Berglund et al.   Science Immunology

Autophagy in Multiple Sclerosis: Two Sides of the Same Coin

(2020) Chairi Misrielal et al.   Frontiers in Cellular Neuroscience

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Author Correction: Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

(2019) Branimir I. Sikic et al.   JOURNAL OF CLINICAL ONCOLOGY

Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter

(2019) Miho Sato-Hashimoto et al.   eLife

Neuronal vulnerability and multilineage diversity in multiple sclerosis

(2019) Lucas Schirmer et al.   NATURE

Central nervous system regeneration is driven by microglia necroptosis and repopulation

(2019) Amy F. Lloyd et al.   NATURE NEUROSCIENCE

Increased lymphocyte activation and atherosclerosis in CD47-deficient mice

(2019) Daniel Engelbertsen et al.   Scientific Reports

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

(2019) Nan Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury

(2019) Gerard Elberg et al.   Journal of Neuroinflammation

CD47-signal regulatory protein α signaling system and its application to cancer immunotherapy

(2018) Yoji Murata et al.   CANCER SCIENCE

Targeting CD47 as a cancer therapeutic strategy

(2018) Alecia S. Folkes et al.   CURRENT OPINION IN ONCOLOGY

Diversity of innate immune cell subsets across spatial and temporal scales in an EAE mouse model

(2018) Céline Caravagna et al.   Scientific Reports

Experimental Autoimmune Encephalomyelitis (EAE) as Animal Models of Multiple Sclerosis (MS)

(2018) Simon Glatigny et al.   Cold Spring Harbor Perspectives in Medicine

Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases

(2018) Hiroyuki Konishi et al.   Frontiers in Cellular Neuroscience

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma

(2018) Ranjana Advani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer immunotherapy targeting the CD47/SIRPα axis

(2017) Kipp Weiskopf   EUROPEAN JOURNAL OF CANCER

Hydraulic Extrusion of the Spinal Cord and Isolation of Dorsal Root Ganglia in Rodents

(2017) Mette Richner et al.   Jove-Journal of Visualized Experiments

Blockade of CD47 ameliorates autoimmune inflammation in CNS by suppressing IL-1-triggered infiltration of pathogenic Th17 cells

(2016) Qiangguo Gao et al.   JOURNAL OF AUTOIMMUNITY

Defects in CD4 + T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47 −/− mice from EAE

(2016) Veronica Azcutia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis

(2016) Barbara Rossi et al.   Frontiers in Immunology

Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs

(2015) Ken Washio et al.   GENES TO CELLS

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial

(2015) Vipul Jairath et al.   LANCET

Pathologic and Protective Roles for Microglial Subsets and Bone Marrow- and Blood-Derived Myeloid Cells in Central Nervous System Inflammation

(2015) Agnieszka Wlodarczyk et al.   Frontiers in Immunology

Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation

(2015) Melanie Greter et al.   Frontiers in Immunology

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock

(2014) Lars B. Holst et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions

(2013) Veronica Azcutia et al.   MOLECULAR BIOLOGY OF THE CELL

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice

(2012) May H. Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial CD47 Promotes Vascular Endothelial-Cadherin Tyrosine Phosphorylation and Participates in T Cell Recruitment at Sites of Inflammation In Vivo

(2012) V. Azcutia et al.   JOURNAL OF IMMUNOLOGY

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

(2011) Miri Gitik et al.   Journal of Neuroinflammation

Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery

(2011) Jeffrey L. Carson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A quantitative assay for the monitoring of autophagosome accumulation in different phases of the cell cycle

(2010) Vitaliy Kaminskyy et al.   Autophagy

Essential roles of SIRPα in homeostatic regulation of skin dendritic cells

(2010) Hiroko Iwamura et al.   IMMUNOLOGY LETTERS

Endothelial CD47 interaction with SIRP  is required for human T-cell transendothelial migration under shear flow conditions in vitro

(2008) M. Stefanidakis et al.   BLOOD

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain

(2008) Karen Bulloch et al.   JOURNAL OF COMPARATIVE NEUROLOGY