Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Neuronal vulnerability and multilineage diversity in multiple sclerosis

(2019) Lucas Schirmer et al.   NATURE

Phagocytosis in the Brain: Homeostasis and Disease

(2019) Dylan A. Galloway et al.   Frontiers in Immunology

Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus

(2019) Katy Poncin et al.   Nature Communications

Comparative analysis of CreER transgenic mice for the study of brain macrophages: A case study

(2019) Louise Chappell‐Maor et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency

(2018) Parisa Lotfi et al.   Autophagy

TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis

(2018) Trent D. Evans et al.   Autophagy

The β 2 Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes

(2018) Alexander Gluschko et al.   Cell Host & Microbe

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

(2018) Ludwig Kappos et al.   LANCET

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

(2018) Harald Lund et al.   NATURE IMMUNOLOGY

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson’s Disease?

(2018) Elzbieta Janda et al.   Frontiers in Molecular Neuroscience

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives

(2018) Cody Wolfe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of the CD200-CD200R Axis During Homeostasis and Neuroinflammation

(2018) Gemma Manich et al.   NEUROSCIENCE

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

(2018) Harald Lund et al.   Nature Communications

NLRX1 Facilitates Histoplasma capsulatum-Induced LC3-Associated Phagocytosis for Cytokine Production in Macrophages

(2018) Juin-Hua Huang et al.   Frontiers in Immunology

Multiple sclerosis

(2018) Massimo Filippi et al.   Nature Reviews Disease Primers

Rubicon: LC3-associated phagocytosis and beyond

(2017) Sing-Wai Wong et al.   FEBS Journal

A Tale of Two Genes: Microglial Apoe and Trem2

(2017) Anna A. Pimenova et al.   IMMUNITY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Older Age at Multiple Sclerosis Onset Is an Independent Factor of Poor Prognosis: A Population-Based Cohort Study

(2017) Francis Guillemin et al.   NEUROEPIDEMIOLOGY

Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival

(2017) Hong Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

(2017) Ismail Sergin et al.   Nature Communications

Aging Microglia—Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases

(2017) Björn Spittau   Frontiers in Aging Neuroscience

Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance

(2017) Zsuzsa Szondy et al.   Frontiers in Immunology

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

The role of autophagy in the pathogenesis of systemic lupus erythematosus

(2016) Xiao Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy Controls Acquisition of Aging Features in Macrophages

(2015) Amanda J. Stranks et al.   Journal of Innate Immunity

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways

(2015) Mohammad Samie et al.   NATURE IMMUNOLOGY

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

Crohn's Disease: Loss of Tolerance or a Disorder of Autophagy?

(2014) Marianne R. Spalinger et al.   DIGESTIVE DISEASES

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains

(2014) Jun-ichi Satoh et al.   Orphanet Journal of Rare Diseases

Microglia change from a reactive to an age-like phenotype with the time in culture

(2014) Cláudia Caldeira et al.   Frontiers in Cellular Neuroscience

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

(2013) Karen Castillo et al.   Autophagy

Vimentin is an endogenous ligand for the pattern recognition receptor Dectin-1

(2013) Praveena S. Thiagarajan et al.   CARDIOVASCULAR RESEARCH

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

The Salih Ataxia Mutation Impairs Rubicon Endosomal Localization

(2013) M. Assoum et al.   CEREBELLUM

Efficacy of vitamin D in treating multiple sclerosis-like neuroinflammation depends on developmental stage

(2013) Milena Z. Adzemovic et al.   EXPERIMENTAL NEUROLOGY

Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity

(2013) M. Thessen Hedreul et al.   HUMAN MOLECULAR GENETICS

Gray matter damage predicts the accumulation of disability 13 years later in MS

(2013) M. Filippi et al.   NEUROLOGY

Comparison of polarization properties of human adult microglia and blood-derived macrophages

(2012) Bryce A. Durafourt et al.   GLIA

Dectin-1-triggered Recruitment of Light Chain 3 Protein to Phagosomes Facilitates Major Histocompatibility Complex Class II Presentation of Fungal-derived Antigens

(2012) Jun Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Age and disability accumulation in multiple sclerosis

(2011) A. Scalfari et al.   NEUROLOGY

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

A quantitative assay for the monitoring of autophagosome accumulation in different phases of the cell cycle

(2010) Vitaliy Kaminskyy et al.   Autophagy

Evidence for a two-stage disability progression in multiple sclerosis

(2010) E. Leray et al.   BRAIN

Mitochondrial clearance is regulated by Atg7-dependent and independent mechanisms during reticulocyte maturation

(2009) J. Zhang et al.   BLOOD

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

(2009) H. H. Pua et al.   JOURNAL OF IMMUNOLOGY

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

(2008) M. Kundu et al.   BLOOD