Article
Oncology
Yitao Gong, Yunzhen Qian, Guopei Luo, Yu Liu, Ruijie Wang, Shengming Deng, He Cheng, Kaizhou Jin, Quanxing Ni, Xianjun Yu, Weiding Wu, Chen Liu
Summary: GFPT1 is generally upregulated in PDAC tissue and is associated with a high risk of LN metastasis and an unfavorable outcome in patients with resectable PDAC, suggesting its crucial role in PDAC progression.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Genetics & Heredity
Gregory C. Wilson, Sameer H. Patel, Jiang Wang, Kui Xu, Kevin M. Turner, Katrin Anne Becker, Alexander Carpinteiro, Ildiko Szabo, Syed A. Ahmad, Erich Gulbins
Summary: Pancreatic adenocarcinoma (PDAC) is a common cancer with poor prognosis. High expression of acid sphingomyelinase is strongly correlated with long-term survival in PDAC patients. Inhibition of acid sphingomyelinase promotes tumor growth and worsens pathology in PDAC mouse models and neoadjuvant treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Chemistry, Analytical
Pablo J. Dopico, Minh-Chau N. Le, Benjamin Burgess, Zhijie Yang, Yu Zhao, Youxiang Wang, Thomas J. George, Z. Hugh Fan
Summary: While patients with resectable pancreatic ductal adenocarcinoma (PDAC) show improved survival, their survival remains low due to occult metastatic disease and treatment resistance. This study tracked circulating biomarkers in resectable PDAC patients throughout treatment and found that the majority of these biomarkers were detected after the start of neoadjuvant therapy but before surgery.
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Shohei Takaichi, Yoshito Tomimaru, Shogo Kobayashi, Keisuke Toya, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Tadafumi Asaoka, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study investigated the impact of changes in body composition on postoperative outcomes in patients with PDAC undergoing neoadjuvant chemoradiotherapy. The results showed that loss of skeletal muscle mass during NACRT was an independent risk factor for survival in PDAC patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Mohammad Hosein Aziz, Jelle C. van Dongen, Lawlaw Saida, Mustafa Suker, Jeroen L. A. van Vugt, Yordi van Putten, Kostandinos Sideras, Jesse V. Groen, J. Sven D. Mieog, Claudia J. Lucassen, Anneke Droop, Katya Mauff, Shirin Shahbazi Feshtali, Bas Groot Koerkamp, Dana A. M. Mustafa, Casper J. van Eijck
Summary: The study found a strong association between preoperative low skeletal muscle mass quantity and elevated host systemic immune inflammation in patients with resected PDAC. Understanding how systemic inflammation may contribute to changes in body composition or whether reversing these changes may affect the host systemic immune inflammation response could expose new therapeutic possibilities for improving patients' survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Kyu Sung, Yejong Park, Bong Jun Kwak, Eunsung Jun, Woohyung Lee, Ki Byung Song, Jae Hoon Lee, Dae Wook Hwang, Song Cheol Kim
Summary: This study found that patients with pancreatic head cancer had lower survival rates compared to those with pancreatic body/tail cancer in resectable PDAC, but tumor location was not an independent prognostic factor for PDAC.
Article
Oncology
Taija Korpela, Ari Ristimaki, Marianne Udd, Tiina Vuorela, Harri Mustonen, Caj Haglund, Leena Kylanpaa, Hanna Seppanen
Summary: This study investigated the potential role of histological chronic pancreatitis findings and chronic inflammation in surgical pancreatic ductal adenocarcinoma (PDAC) specimens on disease-specific survival (DSS). The results suggest that more severe fibrosis, acinar atrophy, and chronic inflammation in the pancreatic stroma were associated with worse DSS outcomes for PDAC patients.
Article
Oncology
Yalu Zhang, Qiaofei Liu, Jingkai Liu, Quan Liao
Summary: CD58 expression is upregulated in PDAC tissues and high expression is associated with poor survival of PDAC patients, suggesting it may serve as a novel and effective marker for predicting the prognosis of PDAC.
CANCER CELL INTERNATIONAL
(2021)
Article
Health Care Sciences & Services
Ying-Ying Cao, Kai Guo, Rui Zhao, Yuan Li, Xiao-Jing Lv, Zi-Peng Lu, Lei Tian, Shuai Ren, Zhong-Qiu Wang
Summary: This study developed a potential biomarker model for the detection of resectable pancreatic ductal adenocarcinoma (PDAC) using tissue and serum metabolomics. The panel of three metabolites, including 16-hydroxypalmitic acid, phenylalanine, and norleucine, showed promising potential in distinguishing resectable PDAC from healthy controls.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Wook Kim, Hyemin Ahn, Kyung Won Kim, Seung Soo Lee, Hwa Jung Kim, Yousun Ko, Taeyong Park, Jeongjin Lee
Summary: This study retrospectively evaluated the prognostic value of muscle quality, including myosteatosis, in 347 patients with resectable PDAC who underwent curative surgery. The results showed that myosteatosis was significantly associated with poorer overall survival and recurrence-free survival.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yucheng Zhang, Edrise M. Lobo-Mueller, Paul Karanicolas, Steven Gallinger, Masoom A. Haider, Farzad Khalvati
Summary: The study found weak linear relationships between deep transfer learning features and radiomics features, indicating a potential complementary relationship. By combining radiomics and transfer learning features, the prognosis performance for predicting overall survival in PDAC patients can be significantly improved.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Karl Knipper, Alexander I. Damanakis, Yue Zhao, Christiane J. Bruns, Thomas Schmidt, Felix C. Popp, Alexander Quaas, Su Ir Lyu
Summary: Despite extensive research, the mortality rate of pancreatic ductal adenocarcinoma remains high. The tumor microenvironment has been found to play a crucial role in carcinogenesis, and this study aimed to characterize the family of cancer-associated fibroblasts. By analyzing the expression patterns of four fibroblast markers in 321 patients, three subgroups associated with poor survival were identified, providing potential targets for future targeted treatments.
Article
Oncology
Toshiya Abe, Kohei Nakata, So Nakamura, Noboru Ideno, Naoki Ikenaga, Nobuhiro Fujita, Kousei Ishigami, Kazuyoshi Nishihara, Masafumi Nakamura
Summary: The study aimed to evaluate the impact of preoperative osteosarcopenia on the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). It was found that patients with osteosarcopenia had significantly shorter overall survival and disease-free survival compared to patients without osteosarcopenia. Osteosarcopenia may be a useful prognostic factor, and further research is needed to evaluate whether perioperative nutritional interventions and rehabilitation contribute to improving the prognosis of these patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Xiaoyang Lan, Gabrielle Robin, Jessica Kasnik, Grace Wong, Omar Abdel-Rahman
Summary: Pancreatic ductal carcinomas (PDACs) are difficult to diagnose early and have a poor prognosis. Many PDAC patients suffer from nutritional deficiencies related to their cancer. Pancreatic enzyme insufficiency (PEI) is a common cause of malnutrition in PDAC. This paper reviews past studies on malnutrition in PDAC, focusing on PEI and its treatment, and highlights knowledge gaps among healthcare professionals regarding PEI.
Article
Gastroenterology & Hepatology
Stephan B. Dreyer, Rosie Upstill-Goddard, Viola Paulus-Hock, Clara Paris, Eirini-Maria Lampraki, Eloise Dray, Bryan Serrels, Giuseppina Caligiuri, Selma Rebus, Dennis Plenker, Zachary Galluzzo, Holly Brunton, Richard Cunningham, Mathias Tesson, Craig Nourse, Ulla-Maja Bailey, Marc Jones, Kim Moran-Jones, Derek W. Wright, Fraser Duthie, Karin Oien, Lisa Evers, Colin J. McKay, Grant A. McGregor, Aditi Gulati, Rachel Brough, Ilirjana Bajrami, Stephan Pettitt, Michele L. Dziubinski, Juliana Candido, Frances Balkwill, Simon T. Barry, Robert Grutzmann, Lola Rahib, Amber Johns, Marina Pajic, Fieke E. M. Froeling, Phillip Beer, Elizabeth A. Musgrove, Gloria M. Petersen, Alan Ashworth, Margaret C. Frame, Howard C. Crawford, Diane M. Simeone, Chris Lord, Debabrata Mukhopadhyay, Christian Pilarsky, David A. Tuveson, Susanna L. Cooke, Nigel B. Jamieson, Jennifer P. Morton, Owen J. Sansom, Peter J. Bailey, Andrew Biankin, David K. Chang
Summary: DDR deficiency and replication stress are independent of each other, offering opportunities for therapy in DDR-proficient PC and after platinum therapy. Patient-derived cell lines faithfully recapitulate the epithelial component of pancreatic tumors, including previously described molecular subtypes, and serve as a valuable model for studying novel therapeutic strategies targeting DDR and replication stress in PC.
Article
Gastroenterology & Hepatology
Johann Gout, Lukas Perkhofer, Mareen Morawe, Frank Arnold, Michaela Ihle, Stephanie Biber, Sebastian Lange, Elodie Roger, Johann M. Kraus, Katja Stifter, Stephan A. Hahn, Andrea Zamperone, Thomas Engleitner, Martin Mueller, Karolin Walter, Eva Rodriguez-Aznar, Bruno Sainz Jr, Patrick C. Hermann, Elisabeth Hessmann, Sebastian Mueller, Ninel Azoitei, Andre Lechel, Stefan Liebau, Martin Wagner, Diane M. Simeone, Hans A. Kestler, Thomas Seufferlein, Lisa Wiesmueller, Roland Rad, Pierre-Olivier Frappart, Alexander Kleger
Summary: The study identified synergistic effects in inhibiting PARP, ATR, and DNA-PKcs that lead to synthetic lethality in ATM-deficient pancreatic ductal adenocarcinoma. Chemical inhibition of ATM sensitized human PDAC cells towards this combinatorial therapy, which was also found to overcome PARP inhibitor resistance. These findings suggest potential mutation-specific therapeutic strategies that may be applied through ATM inhibition regardless of genotype.
Article
Gastroenterology & Hepatology
Robert C. Grant, Robert Denroche, Gun Ho Jang, Klaudia M. Nowak, Amy Zhang, Ayelet Borgida, Spring Holter, James T. Topham, Julie Wilson, Anna Dodd, Raymond Jang, Rebecca Prince, Joanna M. Karasinska, David F. Schaeffer, Yifan Wang, George Zogopoulos, Scott Berry, Diane Simeone, Daniel J. Renouf, Faiyaz Notta, Grainne O'Kane, Jennifer Knox, Sandra Fischer, Steven Gallinger
Summary: Patients with MMRD pancreatic cancer exhibit longer overall survival, distinct histopathological and genomic features, and may benefit from targeted therapies based on their unique genomic drivers.
Article
Cell Biology
Brian M. Larsen, Madhavi Kannan, Lee F. Langer, Benjamin D. Leibowitz, Aicha Bentaieb, Andrea Cancino, Igor Dolgalev, Bridgette E. Drummond, Jonathan R. Dry, Chi-Sing Ho, Gaurav Khullar, Benjamin A. Krantz, Brandon Mapes, Kelly E. McKinnon, Jessica Metti, Jason F. Perera, Tim A. Rand, Veronica Sanchez-Freire, Jenna M. Shaxted, Michelle M. Stein, Michael A. Streit, Yi-Hung Carol Tan, Yilin Zhang, Ende Zhao, Jagadish Venkataraman, Martin C. Stumpe, Jeffrey A. Borgia, Ashiq Masood, Daniel V. T. Catenacci, Jeremy Mathews, Demirkan B. Gursel, Jian-Jun Wei, Theodore H. Welling, Diane M. Simeone, Kevin P. White, Aly A. Khan, Catherine Igartua, Ameen A. Salahudeen
Summary: A robust pan-cancer tumor organoid platform with chemically defined media has been established and neural-network-based high-throughput method has been demonstrated to predict patient-specific heterogeneity in drug responses. These resources are expected to accelerate the broad implementation of organoid models in precision medicine research and personalized therapeutic profiling programs.
Letter
Oncology
Sheng Pan, Randall E. Brand, Lisa A. Lai, David W. Dawson, Timothy R. Donahue, Stephen Kim, Natalia I. Khalaf, Mohamed O. Othman, William E. Fisher, Mary P. Bronner, Diane M. Simeone, Teresa A. Brentnall, Ru Chen
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Tamas A. Gonda, James Farrell, Michael Wallace, Lauren Khanna, Eileen Janec, Richard Kwon, Michael Saunders, Uzma D. Siddiqui, Randall Brand, Diane M. Simeone
Summary: The adoption of a standardized EUS reporting template will improve consistency in clinical decision-making for individuals at risk of pancreatic cancer and provide complete and accurate reporting of pancreatic abnormalities. Standardization will also facilitate research and clinical trial design, allowing for comparison of results across different centers.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Oncology
Jiaqi Shi, Zhujun Yi, Lin Jin, Lili Zhao, Alexander Raskind, Larisa Yeomans, Zeribe C. Nwosu, Diane M. Simeone, Costas A. Lyssiotis, Kathleen A. Stringer, Richard S. Kwon
Summary: (Iso)-butyrylcarnitine has the potential to accurately distinguish malignant from benign pancreatic cysts, with a diagnostic accuracy of 89%. Additionally, 5-oxoproline can differentiate mucinous from non-mucinous cysts with a diagnostic accuracy of 90%, better than glucose.
Review
Gastroenterology & Hepatology
Laura D. Wood, Marcia Irene Canto, Elizabeth M. Jaffee, Diane M. Simeone
Summary: This review discusses the pathogenesis, early detection methods, and treatment considerations of pancreatic ductal adenocarcinoma (PDAC). Recent advances in understanding PDAC have led to significant improvements in detection and treatment, but coordinated efforts are needed to maximize clinical impact for patients and overall survival.
Editorial Material
Biochemical Research Methods
Wout Bittremieux, William Stafford Noble
Review
Radiology, Nuclear Medicine & Medical Imaging
Chenchan Huang, Diane M. Simeone, Lyndon Luk, Elizabeth M. Hecht, Gaurav Khatri, Avinash Kambadakone, Hersh Chandarana, Justin M. Ream, Jessica N. Everett, Alexander Guimaraes, Joy Liau, Anil K. Dasyam, Carla Harmath, Alec J. Megibow
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with poor survival rates. High-risk individuals are recommended to have regular screening with MRI and/or endoscopic ultrasound. The Pancreatic Cancer Early Detection (PRECEDE) Consortium aims to increase survival of PDAC by facilitating earlier diagnosis through standardized MRI screening and reporting.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Minh Huynh, G. Aaron Hobbs, Antje Schaefer, Mariaelena Pierobon, Leiah M. Carey, J. Nathaniel Diehl, Jonathan M. DeLiberty, Ryan D. Thurman, Adelaide R. Cooke, Craig M. Goodwin, Joshua H. Cook, Lin Lin, Andrew M. Waters, Naim U. Rashid, Emanuel F. Petricoin, Sharon L. Campbell, Kevin M. Haigis, Diane M. Simeone, Costas A. Lyssiotis, Adrienne D. Cox, Channing J. Der
Summary: Missense mutations at the three hotspots in RAS-Gly(12), Gly(13), and Gln(61) show differential distribution among the three RAS isoforms. KRAS(Q61) mutants exhibit various changes in morphology, growth transformation, effector signaling, and metabolism. Differences in biochemical, structural, and biological properties may explain the frequency variations. Targeting KRAS(Q61) mutant-specific signaling and cellular output may be a potential therapeutic strategy.
Article
Oncology
Jessica N. Everett, Shenin A. Dettwyler, Xiaohong Jing, Cody Stender, Madeleine Schmitter, Ariele Baptiste, Jennifer Chun, Emily A. Kawaler, Lauren G. Khanna, Seth A. Gross, Tamas A. Gonda, Nina Beri, Paul E. Oberstein, Diane M. Simeone
Summary: Integrating genetics into a multidisciplinary setting improves compliance with genetic testing for pancreatic ductal adenocarcinoma (PDAC) patients, reduces logistical barriers, and clarifies cancer risks for relatives.
Article
Oncology
Jiheng Xu, Rui Yang, Jingxia Li, Lidong Wang, Mitchell Cohen, Diane M. Simeone, Max Costa, Xue-Ru Wu
Summary: The stem-cell-like behavior of cancer cells in bladder cancer plays a crucial role and its molecular basis remains incompletely defined. This study demonstrates that SNHG1 induces the formation of stem-cell-like spheres and invasion of bladder cancer cells by upregulating Rho GTPase, Rac1. SNHG1 binds to DNMT3A and represses the transcription of miR-129-2-5p, resulting in increased Rac1 protein levels. High expression of Rac1 is associated with poor prognosis in bladder cancer patients.
Article
Biochemical Research Methods
Wout Bittremieux, Damon H. May, Jeffrey Bilmes, William Stafford Noble
Summary: This study proposes a new computational method that uses deep neural networks to perform supervised learning on mass spectrometry data for large-scale identification of unknown spectra. By embedding spectra into a lower-dimensional space where spectra generated by the same peptide are close to each other, a group of unidentified similar spectra are detected and identified.
Article
Gastroenterology & Hepatology
Sharon Pan, Lisa A. Lai, Diane M. M. Simeone, David W. W. Dawson, Yuanqing Yan, Tatjana Crnogorac-Jurcevic, Ru Chen, Teresa A. Brentnall
Summary: Proteomic and functional analysis of extracellular vesicles (EVs) released from pancreatic cancer cells and cancer-associated fibroblasts (CAFs) identified over 1400 nonredundant proteins involved in vesicle-mediated transport and exocytosis. Protein networks relevant to pancreatic tumorigenesis, such as epithelial-mesenchymal transition, complement, and coagulation components, were significantly enriched in EVs from cancer cells or CAFs, suggesting a potential role of EVs in mediating signals related to tumorigenesis and microenvironment interactions.
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)
