TGF-β in pancreatic cancer initiation and progression: two sides of the same coin

MED12 is recurrently mutated in Middle Eastern colorectal cancer

(2017) Abdul K Siraj et al.   GUT

Combined targeting of TGF-β, EGFR and HER2 suppresses lymphangiogenesis and metastasis in a pancreatic cancer model

(2016) Jesse Gore et al.   CANCER LETTERS

TGF-β Tumor Suppression through a Lethal EMT

(2016) Charles J. David et al.   CELL

Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors

(2015) Yutaka Fujiwara et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Surgical Management of Pancreatic Cancer—Distal Pancreatectomy

(2015) Purvi Y. Parikh et al.   SEMINARS IN ONCOLOGY

Pancreatic cancer: diagnosis and treatments

(2015) Hong-Yu Li et al.   TUMOR BIOLOGY

Targeting cancer cell metabolism in pancreatic adenocarcinoma

(2015) Romain Cohen et al.   Oncotarget

Advanced pancreatic adenocarcinoma: a review of current treatment strategies and developing therapies

(2015) Andrea Teague et al.   Therapeutic Advances in Medical Oncology

Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas

(2015) Cindy Neuzillet et al.   Oncotarget

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Inhibition of transforming growth factor-β signaling potentiates tumor cell invasion into collagen matrix induced by fibroblast-derived hepatocyte growth factor

(2014) Jun Oyanagi et al.   EXPERIMENTAL CELL RESEARCH

Management Options in Locally Advanced Pancreatic Cancer

(2014) Omar Y. Mian et al.   Current Oncology Reports

Therapeutic Advances in Pancreatic Cancer

(2013) Andrew Scott Paulson et al.   GASTROENTEROLOGY

Loss of Canonical Smad4 Signaling Promotes KRAS Driven Malignant Transformation of Human Pancreatic Duct Epithelial Cells and Metastasis

(2013) Lisa Leung et al.   PLoS One

TGF-  and  v 6 Integrin Act in a Common Pathway to Suppress Pancreatic Cancer Progression

(2012) A. F. Hezel et al.   CANCER RESEARCH

MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

(2012) Sidong Huang et al.   CELL

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Transforming growth factor-beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer

(2011) Karl-Hermann Schlingensiepen et al.   CANCER SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy

(2011) Enza Lonardo et al.   Cell Stem Cell

Transforming Growth Factor-β in the Gastrointestinal and Hepatic Tumor Microenvironment

(2011) Bhagelu Ram Achyut et al.   GASTROENTEROLOGY

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

Side population of pancreatic cancer cells predominates in TGF-β-mediated epithelial to mesenchymal transition and invasion

(2009) Ayano Kabashima et al.   INTERNATIONAL JOURNAL OF CANCER

Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas

(2009) David F. Vincent et al.   PLoS Genetics

Pancreatic Stellate Cells and Pancreatic Cancer Cells: An Unholy Alliance

(2008) A. Vonlaufen et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β

(2008) Kana Horiguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LY2109761, a novel transforming growth factor   receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

(2008) D. Melisi et al.   MOLECULAR CANCER THERAPEUTICS