The Unfolded Protein Response as a Guardian of the Secretory Pathway
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Title
The Unfolded Protein Response as a Guardian of the Secretory Pathway
Authors
Keywords
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Journal
Cells
Volume 10, Issue 11, Pages 2965
Publisher
MDPI AG
Online
2021-11-02
DOI
10.3390/cells10112965
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Note: Only part of the references are listed.- Cysteine cross-linking in native membranes establishes the transmembrane architecture of Ire1
- (2021) Kristina Väth et al. JOURNAL OF CELL BIOLOGY
- Translocation of Proteins through a Distorted Lipid Bilayer
- (2021) Xudong Wu et al. TRENDS IN CELL BIOLOGY
- A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
- (2021) I-Hui Wu et al. Cell Reports
- The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes
- (2021) Ngoc-Han Tran et al. SCIENCE
- Regulation of lipid saturation without sensing membrane fluidity
- (2020) Stephanie Ballweg et al. Nature Communications
- Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
- (2020) Nurulain Ho et al. JOURNAL OF CELL BIOLOGY
- Membrane Lipids Assist Catalysis by CTP: Phosphocholine Cytidylyltransferase
- (2020) Rosemary B. Cornell JOURNAL OF MOLECULAR BIOLOGY
- Mechanisms, regulation and functions of the unfolded protein response
- (2020) Claudio Hetz et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ERdj8 governs the size of autophagosomes during the formation process
- (2020) Yo-hei Yamamoto et al. JOURNAL OF CELL BIOLOGY
- A Quantitative Analysis of Cellular Lipid Compositions During Acute Proteotoxic ER Stress Reveals Specificity in the Production of Asymmetric Lipids
- (2020) John Reinhard et al. Frontiers in Cell and Developmental Biology
- Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast–like Cells Is Driven by an Unfolded Protein Response
- (2020) Abhijnan Chattopadhyay et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response
- (2020) Natacha Larburu et al. Open Biology
- The role of very long chain fatty acids in yeast physiology and human diseases
- (2020) Pia Erdbrügger et al. BIOLOGICAL CHEMISTRY
- A Molecular Mechanism for Turning Off IRE1α Signaling during Endoplasmic Reticulum Stress
- (2020) Xia Li et al. Cell Reports
- Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
- (2020) Steffen Preissler et al. eLife
- The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum
- (2019) G. Elif Karagöz et al. Cold Spring Harbor Perspectives in Biology
- Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids
- (2019) Manuele Piccolis et al. MOLECULAR CELL
- Degradation of Blos1 mRNA by IRE1 repositions lysosomes and protects cells from stress
- (2019) Donghwi Bae et al. JOURNAL OF CELL BIOLOGY
- Intrinsic Structural Features of the Human IRE1α Transmembrane Domain Sense Membrane Lipid Saturation
- (2019) Hyunju Cho et al. Cell Reports
- ERp18 regulates activation of ATF6α during unfolded protein response
- (2019) Ojore BV Oka et al. EMBO JOURNAL
- Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins
- (2019) Peter Shyu et al. Scientific Reports
- Protein quality control in the secretory pathway
- (2019) Zhihao Sun et al. JOURNAL OF CELL BIOLOGY
- Dysregulation of very long chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response
- (2019) Yagmur Micoogullari et al. MOLECULAR BIOLOGY OF THE CELL
- UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor
- (2019) Megan C. Kopp et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Quantitative microscopy reveals dynamics and fate of clustered IRE1α
- (2019) Vladislav Belyy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR
- (2019) Niko Amin-Wetzel et al. eLife
- Retrospective on Cholesterol Homeostasis: The Central Role of Scap
- (2018) Michael S. Brown et al. Annual Review of Biochemistry
- An Emerging Group of Membrane Property Sensors Controls the Physical State of Organellar Membranes to Maintain Their Identity
- (2018) Toni Radanović et al. BIOESSAYS
- Do inositol supplements enhance phosphatidylinositol supply and thus support endoplasmic reticulum function?
- (2018) Robert H. Michell BRITISH JOURNAL OF NUTRITION
- Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses
- (2018) Amado Carreras-Sureda et al. CELL CALCIUM
- Cellular mechanisms of physicochemical membrane homeostasis
- (2018) Robert Ernst et al. CURRENT OPINION IN CELL BIOLOGY
- Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
- (2018) Aitor Almanza et al. FEBS Journal
- The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization
- (2018) Peng Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1
- (2018) Harald F. Hofbauer et al. JOURNAL OF CELL BIOLOGY
- Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress
- (2018) Arunkumar Sundaram et al. MOLECULAR BIOLOGY OF THE CELL
- Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α
- (2018) Denisse Sepulveda et al. MOLECULAR CELL
- The Unfolded Protein Response and Cell Fate Control
- (2018) Claudio Hetz et al. MOLECULAR CELL
- Understanding the diversity of membrane lipid composition
- (2018) Takeshi Harayama et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress
- (2018) Megan C Kopp et al. eLife
- The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
- (2018) Arvin B. Tam et al. DEVELOPMENTAL CELL
- Integrated Functions of Membrane Property Sensors and a Hidden Side of the Unfolded Protein Response
- (2018) Roberto Covino et al. MOLECULAR CELL
- Here, there, and everywhere: The importance of ER membrane contact sites
- (2018) Haoxi Wu et al. SCIENCE
- Categorization of endoplasmic reticulum stress as accumulation of unfolded proteins or membrane lipid aberrancy using yeast Ire1 mutants
- (2018) Duc Minh Tran et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Roles of the endoplasmic reticulum–resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease
- (2018) Shinya Ito et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fat-regulating phosphatidic acid phosphatase: a review of its roles and regulation in lipid homeostasis
- (2018) George M. Carman et al. JOURNAL OF LIPID RESEARCH
- Early Events in the Endoplasmic Reticulum Unfolded Protein Response
- (2018) Steffen Preissler et al. Cold Spring Harbor Perspectives in Biology
- The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
- (2018) Diego Acosta-Alvear et al. eLife
- A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis
- (2017) Ngee Kiat Chua et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy
- (2017) Nozomu Kono et al. MOLECULAR BIOLOGY OF THE CELL
- Activation of the Unfolded Protein Response by Lipid Bilayer Stress
- (2017) Kristina Halbleib et al. MOLECULAR CELL
- Metabolic activity induces membrane phase separation in endoplasmic reticulum
- (2017) Yihui Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting IRE1 with small molecules counteracts progression of atherosclerosis
- (2017) Ozlem Tufanli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An unfolded protein-induced conformational switch activates mammalian IRE1
- (2017) G Elif Karagöz et al. eLife
- ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate
- (2017) Wenfu Ma et al. eLife
- The Sec61 translocon limits IRE1α signaling during the unfolded protein response
- (2017) Arunkumar Sundaram et al. eLife
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- (2016) Rosemary B. Cornell BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- The role of ER stress in lipid metabolism and lipotoxicity
- (2016) Jaeseok Han et al. JOURNAL OF LIPID RESEARCH
- Homeoviscous Adaptation and the Regulation of Membrane Lipids
- (2016) Robert Ernst et al. JOURNAL OF MOLECULAR BIOLOGY
- A Eukaryotic Sensor for Membrane Lipid Saturation
- (2016) Roberto Covino et al. MOLECULAR CELL
- Lipidomics for studying metabolism
- (2016) Xianlin Han Nature Reviews Endocrinology
- Form Follows Function: The Importance of Endoplasmic Reticulum Shape
- (2015) L.M. Westrate et al. Annual Review of Biochemistry
- The Role of Endoplasmic Reticulum Stress in Human Pathology
- (2015) Scott A. Oakes et al. Annual Review of Pathology-Mechanisms of Disease
- Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress
- (2015) Xia Gao et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Sec24 Is a Coincidence Detector that Simultaneously Binds Two Signals to Drive ER Export
- (2015) Silvere Pagant et al. CURRENT BIOLOGY
- Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling
- (2015) M. Carrara et al. EMBO JOURNAL
- A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing
- (2015) J. Peschek et al. EMBO REPORTS
- Phosphatidylethanolamine Is a Key Regulator of Membrane Fluidity in Eukaryotic Cells
- (2015) Rosie Dawaliby et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain
- (2015) R. Mathuranyanon et al. JOURNAL OF CELL SCIENCE
- BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions
- (2015) Julia Behnke et al. JOURNAL OF MOLECULAR BIOLOGY
- A functional link between the co-translational protein translocation pathway and the UPR
- (2015) Rachel Plumb et al. eLife
- Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling
- (2015) Marta Carrara et al. eLife
- Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action
- (2014) G. Elif Karagöz et al. CELL
- The mammalian tRNA ligase complex mediates splicing ofXBP1mRNA and controls antibody secretion in plasma cells
- (2014) Jennifer Jurkin et al. EMBO JOURNAL
- Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association
- (2014) Davide Eletto et al. MOLECULAR CELL
- Lipid landscapes and pipelines in membrane homeostasis
- (2014) Joost C.M. Holthuis et al. NATURE
- Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo
- (2014) N. S. Hou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
- (2014) M. Lu et al. SCIENCE
- Phospholipid Synthesis and Transport in Mammalian Cells
- (2014) Jean E. Vance TRAFFIC
- Membrane lipid saturation activates IRE1α without inducing clustering
- (2013) Yuto Kitai et al. GENES TO CELLS
- BiP-bound and nonclustered mode of Ire1 evokes a weak but sustained unfolded protein response
- (2013) Yuki Ishiwata-Kimata et al. GENES TO CELLS
- Short transmembrane domains with high-volume exoplasmic halves determine retention of Type II membrane proteins in the Golgi complex
- (2013) R. Quiroga et al. JOURNAL OF CELL SCIENCE
- A Lipid E-MAP Identifies Ubx2 as a Critical Regulator of Lipid Saturation and Lipid Bilayer Stress
- (2013) Michal A. Surma et al. MOLECULAR CELL
- Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
- (2013) R. Volmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments
- (2013) Matthew D. Shoulders et al. Cell Reports
- The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling
- (2012) Suneng Fu et al. Cell Metabolism
- Curvature, Lipid Packing, and Electrostatics of Membrane Organelles: Defining Cellular Territories in Determining Specificity
- (2012) Joëlle Bigay et al. DEVELOPMENTAL CELL
- Metabolism and Regulation of Glycerolipids in the Yeast Saccharomyces cerevisiae
- (2012) Susan A. Henry et al. GENETICS
- Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
- (2012) M. Liu et al. JOURNAL OF CELL SCIENCE
- Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells
- (2012) Patrick Lajoie et al. MOLECULAR BIOLOGY OF THE CELL
- The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network
- (2012) Guillaume Thibault et al. MOLECULAR CELL
- Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain
- (2012) F.-Xabier Contreras et al. NATURE
- A Systematic Approach to Pair Secretory Cargo Receptors with Their Cargo Suggests a Mechanism for Cargo Selection by Erv14
- (2012) Yonatan Herzig et al. PLOS BIOLOGY
- Protein Folding and Modification in the Mammalian Endoplasmic Reticulum
- (2011) Ineke Braakman et al. Annual Review of Biochemistry
- Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders
- (2011) Lale Ozcan et al. Annual Review of Medicine
- Oleate Blocks Palmitate-Induced Abnormal Lipid Distribution, Endoplasmic Reticulum Expansion and Stress, and Insulin Resistance in Skeletal Muscle
- (2011) Gong Peng et al. ENDOCRINOLOGY
- Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
- (2011) Thanyarat Promlek et al. MOLECULAR BIOLOGY OF THE CELL
- Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
- (2011) Suneng Fu et al. NATURE
- COPII and the regulation of protein sorting in mammals
- (2011) Giulia Zanetti et al. NATURE CELL BIOLOGY
- Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions
- (2011) Moritz Marcinowski et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein
- (2011) J. Maiuolo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching
- (2011) H.-J. Kaiser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response
- (2011) B. M. Gardner et al. SCIENCE
- Modulating stress responses by the UPRosome: A matter of life and death
- (2011) Ute Woehlbier et al. TRENDS IN BIOCHEMICAL SCIENCES
- A Comprehensive Comparison of Transmembrane Domains Reveals Organelle-Specific Properties
- (2010) Hayley J. Sharpe et al. CELL
- Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
- (2010) Gökhan S. Hotamisligil CELL
- Luminal Domain of ATF6 Alone Is Sufficient for Sensing Endoplasmic Reticulum Stress and Subsequent Transport to the Golgi Apparatus
- (2010) Yoshimi Sato et al. CELL STRUCTURE AND FUNCTION
- Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells
- (2010) Yukio Kimata et al. CURRENT OPINION IN CELL BIOLOGY
- Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response
- (2010) Hiroyuki Ariyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of basal cellular physiology by the homeostatic unfolded protein response
- (2010) D. Thomas Rutkowski et al. JOURNAL OF CELL BIOLOGY
- Lipid-induced insulin resistance: unravelling the mechanism
- (2010) Varman T Samuel et al. LANCET
- Orm family proteins mediate sphingolipid homeostasis
- (2010) David K. Breslow et al. NATURE
- Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control
- (2010) S. Han et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase
- (2010) Eleftherios Karanasios et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering
- (2010) H. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulation of Lipid-Induced ER Stress by Fatty Acid Shape
- (2010) Julie Deguil et al. TRAFFIC
- BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response
- (2010) David Pincus et al. PLOS BIOLOGY
- Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins
- (2009) Daisuke Oikawa et al. EXPERIMENTAL CELL RESEARCH
- Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response
- (2009) Sebastian Schuck et al. JOURNAL OF CELL BIOLOGY
- Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
- (2009) Julie Hollien et al. JOURNAL OF CELL BIOLOGY
- ATF6 induces XBP1-independent expansion of the endoplasmic reticulum
- (2009) H. Bommiasamy et al. JOURNAL OF CELL SCIENCE
- The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response
- (2009) Sana Basseri et al. JOURNAL OF LIPID RESEARCH
- Emerging roles for lipids in shaping membrane-protein function
- (2009) Rob Phillips et al. NATURE
- In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
- (2009) A. J. Schindler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry
- (2009) C. S. Ejsing et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum
- (2009) M. C. Jonikas et al. SCIENCE
- Lipid-Induced ER Stress: Synergistic Effects of Sterols and Saturated Fatty Acids
- (2009) Ludovic Pineau et al. TRAFFIC
- Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing
- (2008) Kenneth P.K. Lee et al. CELL
- Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance
- (2008) Arun Radhakrishnan et al. Cell Metabolism
- Transmembrane domain–dependent partitioning of membrane proteins within the endoplasmic reticulum
- (2008) Paolo Ronchi et al. JOURNAL OF CELL BIOLOGY
- Messenger RNA targeting to endoplasmic reticulum stress signalling sites
- (2008) Tomás Aragón et al. NATURE
- A Lipid-mediated Quality Control Process in the Golgi Apparatus in Yeast
- (2007) Ludovic Pineau et al. MOLECULAR BIOLOGY OF THE CELL
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