Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy

Interleukin-7-loaded oncolytic adenovirus improves CAR-T cell therapy for glioblastoma

(2021) Jianhan Huang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Measles Virus as an Oncolytic Immunotherapy

(2021) Christine E. Engeland et al.   Cancers

Cytokine-Coding Oncolytic Adenovirus TILT-123 Is Safe, Selective, and Effective as a Single Agent and in Combination with Immune Checkpoint Inhibitor Anti-PD-1

(2021) Riikka Havunen et al.   Cells

Oncolytic virotherapy reverses the immunosuppressive tumor microenvironment and its potential in combination with immunotherapy

(2021) Yalei Zhang et al.   Cancer Cell International

Mesenchymal stem cell carriers enhance antitumor efficacy induced by oncolytic reovirus in acute myeloid leukemia

(2021) Xianyao Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Current strategies in engaging oncolytic viruses with antitumor immunity

(2021) Drew Ashton Boagni et al.   Molecular Therapy-Oncolytics

Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition through dynamic intratumoral immune modulation

(2021) Kotaro Sugawara et al.   Molecular Therapy-Oncolytics

Oncolytic vaccinia virus gene modification and cytokine expression effects on tumor infection, immune response, and killing

(2021) Tomoyoshi Inoue et al.   MOLECULAR CANCER THERAPEUTICS

The Effect of Herpes Simplex Virus-Type-1 (HSV-1) Oncolytic Immunotherapy on the Tumor Microenvironment

(2021) Ifeanyi Kingsley Uche et al.   Viruses-Basel

Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes

(2021) Alexander Malogolovkin et al.   Viruses-Basel

Systemic delivery of TNF-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma

(2021) John D. Christie et al.   Molecular Therapy-Oncolytics

Enhanced anti-tumor response elicited by a novel oncolytic HSV-1 engineered with an anti-PD-1 antibody

(2021) Chao Tian et al.   CANCER LETTERS

An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma

(2021) Bo Xu et al.   Nature Communications

Autophagy in Tumor Immunity and Viral-Based Immunotherapeutic Approaches in Cancer

(2021) Ali Zahedi-Amiri et al.   Cells

Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors

(2020) Caroline E. Porter et al.   MOLECULAR THERAPY

CCL5-armed oncolytic virus augments CCR5-engineered NK cell infiltration and antitumor efficiency

(2020) Feng Li et al.   Journal for ImmunoTherapy of Cancer

Oncolytic Virotherapy with Myxoma Virus

(2020) Masmudur M. Rahman et al.   Journal of Clinical Medicine

Oncolytic Virus Encoding a Master Pro-Inflammatory Cytokine Interleukin 12 in Cancer Immunotherapy

(2020) Hong-My Nguyen et al.   Cells

Enhancing therapeutic efficacy of oncolytic vaccinia virus armed with Beclin-1, an autophagic Gene in leukemia and myeloma

(2020) Wen Lei et al.   BIOMEDICINE & PHARMACOTHERAPY

Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

(2020) Jessica Wenthe et al.   CANCER GENE THERAPY

Modeling the Spatiotemporal Dynamics of Oncolytic Viruses and Radiotherapy as a Treatment for Cancer

(2020) Eman Simbawa et al.   Computational and Mathematical Methods in Medicine

Engineering vaccinia virus as an immunotherapeutic battleship to overcome tumor heterogeneity

(2020) Adrian Pelin et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Radiation Attenuates Prostate Tumor Antiviral Responses to Vesicular Stomatitis Virus Containing Interferon-β, Resulting in Pronounced Antitumor Systemic Immune Responses

(2020) Thirupandiyur S Udayakumar et al.   MOLECULAR CANCER RESEARCH

Myxoma Virus-Encoded Host Range Protein M029: A Multifunctional Antagonist Targeting Multiple Host Antiviral and Innate Immune Pathways

(2020) Masmudur M. Rahman et al.   Vaccines

Virotherapy: From single agents to combinatorial treatments

(2020) Anna Maria Malfitano et al.   BIOCHEMICAL PHARMACOLOGY

Immunoradiotherapy as an Effective Therapeutic Strategy in Lung Cancer: From Palliative Care to Curative Intent

(2020) Rodolfo Chicas-Sett et al.   Cancers

Optimizing Oncolytic Viral Design to Enhance Antitumor Efficacy: Progress and Challenges

(2020) Shyambabu Chaurasiya et al.   Cancers

Bi- and Tri-Specific T Cell Engager-Armed Oncolytic Viruses: Next-Generation Cancer Immunotherapy

(2020) Zong Sheng Guo et al.   Biomedicines

Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells

(2020) Ahmed Ghdhban Al-Ziaydi et al.   Cancer Cell International

Combination Immunotherapy Using Oncolytic Virus for the Treatment of Advanced Solid Tumors

(2020) Chang-Myung Oh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neural Stem Cells Improve the Delivery of Oncolytic Chimeric Orthopoxvirus in a Metastatic Ovarian Cancer Model

(2020) Mohamed Hammad et al.   Molecular Therapy-Oncolytics

Clinical landscape of oncolytic virus research in 2020

(2020) Nicholas Macedo et al.   Journal for ImmunoTherapy of Cancer

Cell death signalling in virus infection

(2020) Gergely Imre   CELLULAR SIGNALLING

Cytokines in oncolytic virotherapy

(2020) Jonathan G. Pol et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The discovery and development of oncolytic viruses: are they the future of cancer immunotherapy?

(2020) Shunchuan Zhang et al.   Expert Opinion on Drug Discovery

Oncolytic Viruses and Immune Checkpoint Inhibitors: Preclinical Developments to Clinical Trials

(2020) June Kyu Hwang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recombinant Orthopoxvirus Primes Colon Cancer for Checkpoint Inhibitor and Cross-Primes T Cells for Antitumor and Antiviral Immunity

(2020) Sang-In Kim et al.   MOLECULAR CANCER THERAPEUTICS

Targeting immunogenic cell death in cancer

(2020) Asma Ahmed et al.   Molecular Oncology

NSCs are permissive to oncolytic Myxoma virus and provide a delivery method for targeted ovarian cancer therapy

(2020) Yvonne Cornejo et al.   Oncotarget

ONCR-177, an Oncolytic HSV-1 Designed to Potently Activate Systemic Antitumor Immunity

(2020) Brian B Haines et al.   Cancer Immunology Research

Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade

(2020) Sharmila Nair et al.   JCI Insight

Crosstalk between oncolytic viruses and autophagy in cancer therapy

(2020) Ke-Tao Jin et al.   BIOMEDICINE & PHARMACOTHERAPY

Oncolytic viruses: overcoming translational challenges

(2019) Jordi Martinez-Quintanilla et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival

(2019) Patrick Kellish et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma

(2019) Praveen K. Bommareddy et al.   OncoImmunology

Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

(2019) Naiara Martinez-Velez et al.   Acta Neuropathologica Communications

Talimogene laherparepvec: review of its mechanism of action and clinical efficacy and safety

(2019) Steven S Raman et al.   Immunotherapy

Optimizing oncolytic virotherapy in cancer treatment

(2019) Kevin Harrington et al.   NATURE REVIEWS DRUG DISCOVERY

Oncolytic Maraba virus armed with tumor antigen boosts vaccine priming and reveals diverse therapeutic response patterns when combined with checkpoint blockade in ovarian cancer

(2019) A. J. Robert McGray et al.   Journal for ImmunoTherapy of Cancer

Experimental evolution generates novel oncolytic vesicular stomatitis viruses with improved replication in virus-resistant pancreatic cancer cells

(2019) Sara L. Seegers et al.   JOURNAL OF VIROLOGY

Engineering Newcastle disease virus as oncolytic vector for intratumoral delivery of immune checkpoint inhibitors and immunocytokines

(2019) Gayathri Vijayakumar et al.   JOURNAL OF VIROLOGY

Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples

(2019) Eleanor M. Scott et al.   Journal for ImmunoTherapy of Cancer

Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

(2019) Jenna H. Newman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Armed oncolytic viruses: A kick-start for anti-tumor immunity

(2018) J.F. de Graaf et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Fighting Cancer with Viruses: Oncolytic Virus Therapy in China

(2018) Ding Wei et al.   HUMAN GENE THERAPY

PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy

(2018) Dmitriy Zamarin et al.   JOURNAL OF CLINICAL INVESTIGATION

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The advent of oncolytic virotherapy in oncology: The Rigvir® story

(2018) Pēteris Alberts et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Defects in interferon pathways as potential biomarkers of sensitivity to oncolytic viruses

(2018) Olga V. Matveeva et al.   REVIEWS IN MEDICAL VIROLOGY

Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer

(2018) Rachael Mooney et al.   Molecular Therapy-Oncolytics

Oncolytic virus-induced cell death and immunity: a match made in heaven?

(2017) Jolien De Munck et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis

(2017) et al.   Viruses-Basel

Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent

(2017) Pengju Wang et al.   Nature Communications

Rationale and Design of a Phase 1 Clinical Trial to Evaluate HSV G207 Alone or with a Single Radiation Dose in Children with Progressive or Recurrent Malignant Supratentorial Brain Tumors

(2017) Alicia M. Waters et al.   Human Gene Therapy Clinical Development

Oncolytic Viruses in Cancer Treatment

(2017) Sean E. Lawler et al.   JAMA Oncology

Combining Oncolytic Adenovirus with Radiation—A Paradigm for the Future of Radiosensitization

(2017) Sean M. O’Cathail et al.   Frontiers in Oncology

The Host Cell Receptors for Measles Virus and Their Interaction with the Viral Hemagglutinin (H) Protein

(2016) Liang-Tzung Lin et al.   Viruses-Basel

Arming oncolytic viruses to leverage antitumor immunity

(2015) Tanja D de Gruijl et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses

(2015) Norman Woller et al.   MOLECULAR THERAPY

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network

(2015) Christopher M. Goodwin et al.   TRENDS IN MICROBIOLOGY

Stem Cell-Based Cell Carrier for Targeted Oncolytic Virotherapy: Translational Opportunity and Open Questions

(2015) Janice Kim et al.   Viruses-Basel

Going viral: a review of replication-selective oncolytic adenoviruses

(2015) Christopher Larson et al.   Oncotarget

Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia

(2015) Yin Tong et al.   Oncotarget

Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma

(2015) Chunyan Li et al.   Oncotarget

Re-engineering Vesicular Stomatitis Virus to Abrogate Neurotoxicity, Circumvent Humoral Immunity, and Enhance Oncolytic Potency

(2014) A. Muik et al.   CANCER RESEARCH

Viruses for Tumor Therapy

(2014) John Bell et al.   Cell Host & Microbe

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

(2014) Christine E Engeland et al.   MOLECULAR THERAPY

Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy

(2014) D. Zamarin et al.   Science Translational Medicine

Oncolytic Poxviruses

(2014) Winnie M. Chan et al.   Annual Review of Virology

Evaluation of the Safety and Biodistribution of M032, an Attenuated Herpes Simplex Virus Type 1 Expressing hIL-12, After Intracerebral Administration to Aotus Nonhuman Primates

(2014) Justin C. Roth et al.   Human Gene Therapy Clinical Development

Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans

(2013) C. J. Breitbach et al.   CANCER RESEARCH

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication

(2012) Chunchun Meng et al.   ARCHIVES OF VIROLOGY

Pro-Oncogenic Cell Signaling Machinery as a Target for Oncolytic Viruses

(2012) Emma Borrego-Diaz et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity

(2012) Rohann J.M. Correa et al.   GYNECOLOGIC ONCOLOGY

Effect of γ34.5 Deletions on Oncolytic Herpes Simplex Virus Activity in Brain Tumors

(2012) Ryuichi Kanai et al.   JOURNAL OF VIROLOGY

Myxoma Virus Sensitizes Cancer Cells to Gemcitabine and Is an Effective Oncolytic Virotherapeutic in Models of Disseminated Pancreatic Cancer

(2012) Sonia Tusell Wennier et al.   MOLECULAR THERAPY

Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response

(2012) M. Beneteau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemokine Expression From Oncolytic Vaccinia Virus Enhances Vaccine Therapies of Cancer

(2011) Jun Li et al.   MOLECULAR THERAPY

Adenoviruses induce autophagy to promote virus replication and oncolysis

(2011) Humberto Rodriguez-Rocha et al.   VIROLOGY

Some Attenuated Variants of Vesicular Stomatitis Virus Show Enhanced Oncolytic Activity against Human Glioblastoma Cells relative to Normal Brain Cells

(2009) G. Wollmann et al.   JOURNAL OF VIROLOGY

Engineered Newcastle Disease Virus as an Improved Oncolytic Agent Against Hepatocellular Carcinoma

(2009) Jennifer Altomonte et al.   MOLECULAR THERAPY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Targeted Oncolytic Poxvirus JX-594 Demonstrates Antitumoral, Antivascular, and Anti-HBV Activities in Patients With Hepatocellular Carcinoma

(2008) Ta-Chiang Liu et al.   MOLECULAR THERAPY