Measles Virus as an Oncolytic Immunotherapy

Opportunities to debottleneck the downstream processing of the oncolytic measles virus

(2020) Daniel Loewe et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Sequencing of serially passaged measles virus affirms its genomic stability and reveals a nonrandom distribution of consensus mutations

(2020) Mathias Felix Leber et al.   JOURNAL OF GENERAL VIROLOGY

Type 1 Interferon Responses Underlie Tumor-Selective Replication of Oncolytic Measles Virus

(2020) Sarah Aref et al.   MOLECULAR THERAPY

The Susceptibility of Human Melanoma Cells to Infection with the Leningrad-16 Vaccine Strain of Measles Virus

(2020) Yulia Ammour et al.   Viruses-Basel

Measles Vaccines Designed for Enhanced CD8+ T Cell Activation

(2020) Elena Busch et al.   Viruses-Basel

Oncolytic measles virus therapy enhances tumor antigen-specific T-cell responses in patients with multiple myeloma

(2020) Nandakumar Packiriswamy et al.   LEUKEMIA

Mechanisms of measles virus oncolytic immunotherapy

(2020) Gemma Pidelaserra-Martí et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Engineering and combining oncolytic measles virus for cancer therapy

(2020) Mathias F. Leber et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Measles virus-based treatments trigger a pro-inflammatory cascade and a treatment-specific immunopeptidome in glioblastoma

(2019) Srinath Rajaraman et al.   Molecular Therapy-Oncolytics

Combination of Oncolytic Measles Virus Armed With BNiP3, a Pro-apoptotic Gene and Paclitaxel Induces Breast Cancer Cell Death

(2019) Geetanjali Lal et al.   Frontiers in Oncology

In vitro and in silico multidimensional modeling of oncolytic tumor virotherapy dynamics

(2019) David R. Berg et al.   PLoS Computational Biology

Photocontrollable mononegaviruses

(2019) Maino Tahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A key anti-viral protein, RSAD2/VIPERIN, restricts the release of measles virus from infected cells

(2019) Cheyne Kurokawa et al.   VIRUS RESEARCH

Combination of Vaccine Strain Measles Virus and Nimotuzumab in the Treatment of Laryngeal Cancer

(2019) NGUYEN LINH TOAN et al.   ANTICANCER RESEARCH

Chemovirotherapeutic Treatment Using Camptothecin Enhances Oncolytic Measles Virus-Mediated Killing of Breast Cancer Cells

(2019) Chen-Jei Tai et al.   Scientific Reports

A recombinant measles virus vaccine strain rMV-Hu191 has oncolytic effect against human gastric cancer by inducing apoptotic cell death requiring integrity of lipid raft microdomains

(2019) Yao Lv et al.   CANCER LETTERS

Graphene oxide arms oncolytic measles virus for improved effectiveness of cancer therapy

(2019) Mao Xia et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Forced Degradation Studies to Identify Critical Process Parameters for the Purification of Infectious Measles Virus

(2019) Loewe et al.   Viruses-Basel

Chemovirotherapy for pancreatic cancer: Gemcitabine plus oncolytic measles vaccine virus

(2019) Verena May et al.   Oncology Letters

Immunological Effects and Viral Gene Expression Determine the Efficacy of Oncolytic Measles Vaccines Encoding IL-12 or IL-15 Agonists

(2019) Backhaus et al.   Viruses-Basel

Biological treatment of pediatric sarcomas by combined virotherapy and NK cell therapy

(2019) Chihab Klose et al.   BMC CANCER

Combination of Vaccine-Strain Measles and Mumps Viruses Enhances Oncolytic Activity against Human Solid Malignancies

(2018) Ho Anh Son et al.   CANCER INVESTIGATION

Targeted BiTE Expression by an Oncolytic Vector Augments Therapeutic Efficacy Against Solid Tumors

(2018) Tobias Speck et al.   CLINICAL CANCER RESEARCH

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy

(2018) Cheyne Kurokawa et al.   JNCI-Journal of the National Cancer Institute

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy

(2018) Cheyne Kurokawa et al.   JNCI-Journal of the National Cancer Institute

Turning cold tumours hot: oncolytic virotherapy gets up close and personal with other therapeutics at the 11th Oncolytic Virus Conference

(2018) Arthur Dyer et al.   CANCER GENE THERAPY

Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy

(2018) Antoni Ribas et al.   CELL

In Vivo Imaging of Oncolytic Measles Virus Propagation with Single-Cell Resolution

(2018) Iris Kemler et al.   Molecular Therapy-Oncolytics

Measles Virus Enters Breast and Colon Cancer Cell Lines through a PVRL4-Mediated Macropinocytosis Pathway

(2017) Sebastien Delpeut et al.   JOURNAL OF VIROLOGY

Measles

(2017) William J Moss   LANCET

Phase I trial of systemic administration of Edmonston strain of measles virus genetically engineered to express the sodium iodide symporter in patients with recurrent or refractory multiple myeloma

(2017) A Dispenzieri et al.   LEUKEMIA

Molecular Effects of Stromal-Selective Targeting by uPAR-Retargeted Oncolytic Virus in Breast Cancer

(2017) Yuqi Jing et al.   MOLECULAR CANCER RESEARCH

Vaccine platform recombinant measles virus

(2017) Michael D. Mühlebach   VIRUS GENES

Cap-dependent translational control of oncolytic measles virus infection in malignant mesothelioma

(2017) Blake A. Jacobson et al.   Oncotarget

Antigen-specific oncolytic MV-based tumor vaccines through presentation of selected tumor-associated antigens on infected cells or virus-like particles

(2017) Stefan Hutzler et al.   Scientific Reports

Oncolytic measles virus enhances antitumour responses of adoptive CD8+NKG2D+ cells in hepatocellular carcinoma treatment

(2017) Aiping Chen et al.   Scientific Reports

Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation

(2017) Rūta Veinalde et al.   OncoImmunology

Using Cystine Knot Proteins as a Novel Approach to Retarget Oncolytic Measles Virus

(2017) Sangeet Lal et al.   Molecular Therapy-Oncolytics

Measles virus selectively blind to signaling lymphocyte activity molecule has oncolytic efficacy against nectin-4-expressing pancreatic cancer cells

(2016) Mutsumi Awano et al.   CANCER SCIENCE

Macrophage response to oncolytic paramyxoviruses potentiates virus-mediated tumor cell killing

(2016) Darren Qiancheng Tan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel epi-virotherapeutic treatment of pancreatic cancer combining the oral histone deacetylase inhibitor resminostat with oncolytic measles vaccine virus

(2016) Tim Patrick Ellerhoff et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MiR-31 and miR-128 regulates poliovirus receptor-related 4 mediated measles virus infectivity in tumors

(2016) Hirosha Geekiyanage et al.   Molecular Oncology

The Role of Neutrophils in Measles Virus–mediated Oncolysis Differs Between B-cell Malignancies and Is Not Always Enhanced by GCSF

(2016) Aditi Dey et al.   MOLECULAR THERAPY

Immunovirotherapy with measles virus strains in combination with anti–PD-1 antibody blockade enhances antitumor activity in glioblastoma treatment

(2016) Jayson Hardcastle et al.   NEURO-ONCOLOGY

The Host Cell Receptors for Measles Virus and Their Interaction with the Viral Hemagglutinin (H) Protein

(2016) Liang-Tzung Lin et al.   Viruses-Basel

Measles to the Rescue: A Review of Oncolytic Measles Virus

(2016) Sarah Aref et al.   Viruses-Basel

Oncolytic Activity of a Recombinant Measles Virus, Blind to Signaling Lymphocyte Activation Molecule, Against Colorectal Cancer Cells

(2016) Yosuke Amagai et al.   Scientific Reports

Safety Study: Intraventricular Injection of a Modified Oncolytic Measles Virus into Measles-Immune, hCD46-Transgenic, IFNαRko Mice

(2016) Sangeet Lal et al.   Human Gene Therapy Clinical Development

Oncolytic measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by human myeloid and plasmacytoid dendritic cells

(2016) Carole Achard et al.   OncoImmunology

Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

(2016) Guy Ungerechts et al.   Molecular Therapy-Methods & Clinical Development

A novel, polymer-coated oncolytic measles virus overcomes immune suppression and induces robust antitumor activity

(2016) Kaname Nosaki et al.   Molecular Therapy-Oncolytics

Reverse genetics of Mononegavirales: How they work, new vaccines, and new cancer therapeutics

(2015) Christian K. Pfaller et al.   VIROLOGY

Deficiency of caspase 3 in tumor xenograft impairs therapeutic effect of measles virus Edmoston strain

(2015) Biao Wang et al.   Oncotarget

Sensitivity of human pleural mesothelioma to oncolytic measles virus depends on defects of the type I interferon response

(2015) Carole Achard et al.   Oncotarget

Biosafety considerations for attenuated measles virus vectors used in virotherapy and vaccination

(2015) Aline Baldo et al.   Human Vaccines & Immunotherapeutics

Combination of the oral histone deacetylase inhibitor resminostat with oncolytic measles vaccine virus as a new option for epi-virotherapeutic treatment of hepatocellular carcinoma

(2015) Benjamin Ruf et al.   Molecular Therapy-Oncolytics

Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma

(2015) Chunyan Li et al.   Oncotarget

Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin

(2014) Brian Hutzen et al.   BMC CANCER

Oncolytic Measles Virus Expressing the Sodium Iodide Symporter to Treat Drug-Resistant Ovarian Cancer

(2014) E. Galanis et al.   CANCER RESEARCH

Mitophagy Enhances Oncolytic Measles Virus Replication by Mitigating DDX58/RIG-I-Like Receptor Signaling

(2014) M. Xia et al.   JOURNAL OF VIROLOGY

Remission of Disseminated Cancer After Systemic Oncolytic Virotherapy

(2014) Stephen J. Russell et al.   MAYO CLINIC PROCEEDINGS

CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

(2014) Christine E Engeland et al.   MOLECULAR THERAPY

Inhibitors of the Interferon Response Enhance Virus Replication In Vitro

(2014) Claire E. Stewart et al.   PLoS One

Artificial riboswitches for gene expression and replication control of DNA and RNA viruses

(2014) Patrick Ketzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human mesenchymal stromal cells deliver systemic oncolytic measles virus to treat acute lymphoblastic leukemia in the presence of humoral immunity

(2013) A. Castleton et al.   BLOOD

Inhibition of Rho-associated coiled-coil-forming kinase increases efficacy of measles virotherapy

(2013) M Opyrchal et al.   CANCER GENE THERAPY

Specific Elimination of CD133+ Tumor Cells with Targeted Oncolytic Measles Virus

(2013) P. Bach et al.   CANCER RESEARCH

Enhanced susceptibility of B lymphoma cells to measles virus by Epstein-Barr virus type III latency that upregulates CD150/signaling lymphocytic activation molecule

(2013) Satoshi Takeda et al.   CANCER SCIENCE

Measles Virus Vaccine-Infected Tumor Cells Induce Tumor Antigen Cross-Presentation by Human Plasmacytoid Dendritic Cells

(2013) J.-B. Guillerme et al.   CLINICAL CANCER RESEARCH

Enhancing cytokine-induced killer cell therapy of multiple myeloma

(2013) Chunsheng Liu et al.   EXPERIMENTAL HEMATOLOGY

An armed oncolytic measles vaccine virus eliminates human hepatoma cells independently of apoptosis

(2013) J Lampe et al.   GENE THERAPY

Enhanced killing of ovarian carcinoma using oncolytic measles vaccine virus armed with a yeast cytosine deaminase and uracil phosphoribosyltransferase

(2013) A.D. Hartkopf et al.   GYNECOLOGIC ONCOLOGY

Granulocyte-Macrophage Colony-Stimulating Factor-Armed Oncolytic Measles Virus Is an Effective Therapeutic Cancer Vaccine

(2013) Christian Grossardt et al.   HUMAN GENE THERAPY

A Novel Armed Oncolytic Measles Vaccine Virus for the Treatment of Cholangiocarcinoma

(2013) Sebastian Lange et al.   HUMAN GENE THERAPY

Enhanced killing of therapy-induced senescent tumor cells by oncolytic measles vaccine viruses

(2013) Timo Weiland et al.   INTERNATIONAL JOURNAL OF CANCER

Primary resistance phenomena to oncolytic measles vaccine viruses

(2013) MARKUS NOLL et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Innate Immune Defense Defines Susceptibility of Sarcoma Cells to Measles Vaccine Virus-Based Oncolysis

(2013) S. Berchtold et al.   JOURNAL OF VIROLOGY

DARPin-targeting of Measles Virus: Unique Bispecificity, Effective Oncolysis, and Enhanced Safety

(2013) Katrin Friedrich et al.   MOLECULAR THERAPY

Natural Oncolytic Activity of Live-Attenuated Measles Virus against Human Lung and Colorectal Adenocarcinomas

(2013) Nicolas Boisgerault et al.   Biomed Research International

Intrahepatic Application of Suicide Gene-Armed Measles Virotherapeutics: A Safety Study in Transgenic Mice and Rhesus Macaques

(2013) Iris Völker et al.   Human Gene Therapy Clinical Development

Oncolytic measles virus strains have significant antitumor activity against glioma stem cells

(2012) C Allen et al.   GENE THERAPY

Using clinically approved cyclophosphamide regimens to control the humoral immune response to oncolytic viruses

(2012) K-W Peng et al.   GENE THERAPY

Monitoring the initial delivery of an oncolytic measles virus encoding the human sodium iodide symporter to solid tumors using contrast-enhanced computed tomography

(2012) Alan R. Penheiter et al.   JOURNAL OF GENE MEDICINE

Chemovirotherapy of Malignant Melanoma with a Targeted and Armed Oncolytic Measles Virus

(2012) Johanna K. Kaufmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Expression of Immunomodulatory Neutrophil-activating Protein of Helicobacter pylori Enhances the Antitumor Activity of Oncolytic Measles Virus

(2012) Ianko D Iankov et al.   MOLECULAR THERAPY

Nectin 4 is the epithelial cell receptor for measles virus

(2012) Ryan S. Noyce et al.   TRENDS IN MICROBIOLOGY

Polyinosinic acid decreases sequestration and improves systemic therapy of measles virus

(2011) Y-P Liu et al.   CANCER GENE THERAPY

Armed and targeted measles virus for chemovirotherapy of pancreatic cancer

(2011) S Bossow et al.   CANCER GENE THERAPY

Pinhole micro-SPECT/CT for noninvasive monitoring and quantitation of oncolytic virus dispersion and percent infection in solid tumors

(2011) A R Penheiter et al.   GENE THERAPY

Measles virus causes immunogenic cell death in human melanoma

(2011) O G Donnelly et al.   GENE THERAPY

Measles virotherapy in a mouse model of adult T-cell leukaemia/lymphoma

(2011) C. Parrula et al.   JOURNAL OF GENERAL VIROLOGY

Attenuated, Oncolytic, but Not Wild-Type Measles Virus Infection Has Pleiotropic Effects on Human Neutrophil Function

(2011) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Envelope-chimeric Entry-targeted Measles Virus Escapes Neutralization and Achieves Oncolysis

(2011) Tanner S Miest et al.   MOLECULAR THERAPY

Differential Cytopathology and Kinetics of Measles Oncolysis in Two Primary B-cell Malignancies Provides Mechanistic Insights

(2011) Bella Patel et al.   MOLECULAR THERAPY

MicroRNA-sensitive Oncolytic Measles Viruses for Cancer-specific Vector Tropism

(2011) Mathias F Leber et al.   MOLECULAR THERAPY

Adherens junction protein nectin-4 is the epithelial receptor for measles virus

(2011) Michael D. Mühlebach et al.   NATURE

Oncolytic measles viruses encoding interferon β and the thyroidal sodium iodide symporter gene for mesothelioma virotherapy

(2010) H Li et al.   CANCER GENE THERAPY

Liver Cancer Protease Activity Profiles Support Therapeutic Options with Matrix Metalloproteinase-Activatable Oncolytic Measles Virus

(2010) M. D. Muhlebach et al.   CANCER RESEARCH

Phase I Trial of Intraperitoneal Administration of an Oncolytic Measles Virus Strain Engineered to Express Carcinoembryonic Antigen for Recurrent Ovarian Cancer

(2010) E. Galanis et al.   CANCER RESEARCH

CD20-targeted measles virus shows high oncolytic specificity in clinical samples from lymphoma patients independent of prior rituximab therapy

(2010) K-C Yaiw et al.   GENE THERAPY

Enhanced Antitumor Effects of an Engineered Measles Virus Edmonston Strain Expressing the Wild-type N , P , L Genes on Human Renal Cell Carcinoma

(2010) Xin Meng et al.   MOLECULAR THERAPY

Systemic Therapy of Disseminated Myeloma in Passively Immunized Mice Using Measles Virus-infected Cell Carriers

(2010) Chunsheng Liu et al.   MOLECULAR THERAPY

Demonstration of anti-tumor activity of oncolytic measles virus strains in a malignant pleural effusion breast cancer model

(2009) Ianko D. Iankov et al.   BREAST CANCER RESEARCH AND TREATMENT

Optimization of Virotherapy for Cancer

(2009) Matt Biesecker et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Tumor and Vascular Targeting of a Novel Oncolytic Measles Virus Retargeted against the Urokinase Receptor

(2009) Yuqi Jing et al.   CANCER RESEARCH

Mesenchymal Stem Cell Carriers Protect Oncolytic Measles Viruses from Antibody Neutralization in an Orthotopic Ovarian Cancer Therapy Model

(2009) E. K. Mader et al.   CLINICAL CANCER RESEARCH

Intravascularly Administered RGD-Displaying Measles Viruses Bind to and Infect Neovessel Endothelial Cells In Vivo

(2009) Hooi Tin Ong et al.   MOLECULAR THERAPY

Measles Virus Induces Oncolysis of Mesothelioma Cells and Allows Dendritic Cells to Cross-Prime Tumor-Specific CD8 Response

(2008) A. Gauvrit et al.   CANCER RESEARCH

Heat shock protein inhibitors increase the efficacy of measles virotherapy

(2008) C Liu et al.   GENE THERAPY

Toxicology Study of Repeat Intracerebral Administration of a Measles Virus Derivative Producing Carcinoembryonic Antigen in Rhesus Macaques in Support of a Phase I/II Clinical Trial for Patients with Recurrent Gliomas

(2008) Rae Myers et al.   HUMAN GENE THERAPY

Dynamic Interaction of the Measles Virus Hemagglutinin with Its Receptor Signaling Lymphocytic Activation Molecule (SLAM, CD150)

(2008) Chanakha K. Navaratnarajah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modeling of cancer virotherapy with recombinant measles viruses

(2008) Željko Bajzer et al.   JOURNAL OF THEORETICAL BIOLOGY

Interleukin-13 Displaying Retargeted Oncolytic Measles Virus Strains Have Significant Activity Against Gliomas With Improved Specificity

(2008) Cory Allen et al.   MOLECULAR THERAPY