Immune landscape in vulvar cancer-draining lymph nodes indicates distinct immune escape mechanisms in support of metastatic spread and growth

PD-L1 expression and survival in p16-negative and -positive squamous cell carcinomas of the vulva

(2020) Bastian Czogalla et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A pre‐existing coordinated inflammatory microenvironment is associated with complete response of vulvar high‐grade squamous intraepithelial lesions to different forms of immunotherapy

(2020) Ziena Abdulrahman et al.   INTERNATIONAL JOURNAL OF CANCER

CD163+ cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer

(2020) Saskia J Santegoets et al.   Journal for ImmunoTherapy of Cancer

Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy

(2020) David M. Francis et al.   Science Translational Medicine

The Immune System Computes the State of the Body: Crowd Wisdom, Machine Learning, and Immune Cell Reference Repertoires Help Manage Inflammation

(2019) Irun R. Cohen et al.   Frontiers in Immunology

Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

(2019) A. M. Heeren et al.   Journal for ImmunoTherapy of Cancer

Unlocking the therapeutic potential of primary tumor-draining lymph nodes

(2019) Jossie Rotman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Clinical impact of PD-L1 and PD-1 expression in squamous cell cancer of the vulva

(2019) Fabinshy Thangarajah et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

(2019) Kim M. van Pul et al.   Journal for ImmunoTherapy of Cancer

Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial

(2019) R. Wendel Naumann et al.   JOURNAL OF CLINICAL ONCOLOGY

High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status

(2019) Kim E. Kortekaas et al.   Journal for ImmunoTherapy of Cancer

CD274 (PD-L1), CDKN2A (p16), TP53, and EGFR immunohistochemical profile in primary, recurrent and metastatic vulvar cancer

(2019) Sofia Lérias et al.   MODERN PATHOLOGY

PD-L1 receptor expression in vulvar carcinomas is HPV-independent

(2018) M. Choschzick et al.   VIRCHOWS ARCHIV

PD-L1 and IDO Expression in Cervical and Vulvar Invasive and Intraepithelial Squamous Neoplasias: Implications for Combination Immunotherapy

(2018) Zachary Chinn et al.   HISTOPATHOLOGY

PD-L1 expression on immune cells is a favorable prognostic factor for vulvar squamous cell carcinoma patients

(2017) Jacek J. Sznurkowski et al.   Oncotarget

Tumoral PD-L1 expression defines a subgroup of poor-prognosis vulvar carcinomas with non-viral etiology

(2017) Thomas Hecking et al.   Oncotarget

Local immune response depends on p16INK4a status of primary tumor in vulvar squamous cell carcinoma

(2017) Jacek J. Sznurkowski et al.   Oncotarget

Melanoma Sequentially Suppresses Different DC Subsets in the Sentinel Lymph Node, Affecting Disease Spread and Recurrence

(2017) Mari F.C.M. van den Hout et al.   Cancer Immunology Research

The overexpression of p16 is not a surrogate marker for high-risk human papilloma virus genotypes and predicts clinical outcomes for vulvar cancer

(2016) Jacek J. Sznurkowski et al.   BMC CANCER

Squamous precursor lesions of the vulva: current classification and diagnostic challenges

(2016) Lien N. Hoang et al.   PATHOLOGY

Genetic Basis for PD-L1 Expression in Squamous Cell Carcinomas of the Cervix and Vulva

(2016) Brooke E. Howitt et al.   JAMA Oncology

Adjuvant Therapy in Lymph Node–Positive Vulvar Cancer: The AGO-CaRE-1 Study

(2015) Sven Mahner et al.   JNCI-Journal of the National Cancer Institute

Adjuvant Therapy in Lymph Node–Positive Vulvar Cancer: The AGO-CaRE-1 Study

(2015) Sven Mahner et al.   JNCI-Journal of the National Cancer Institute

The clinical impact of using p16INK4aimmunochemistry in cervical histopathology and cytology: An update of recent developments

(2014) Christine Bergeron et al.   INTERNATIONAL JOURNAL OF CANCER

Expression of coinhibitory receptors on T cells in the microenvironment of usual vulvar intraepithelial neoplasia is related to proinflammatory effector T cells and an increased recurrence-free survival

(2014) Edith M.G. van Esch et al.   INTERNATIONAL JOURNAL OF CANCER

Suppression of Langerhans cell activation is conserved amongst human papillomavirus α and β genotypes, but not a µ genotype

(2014) Diane M. Da Silva et al.   VIROLOGY

Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues

(2014) I. Theate et al.   Cancer Immunology Research

High and Interrelated Rates of PD-L1+CD14+ Antigen-Presenting Cells and Regulatory T Cells Mark the Microenvironment of Metastatic Lymph Nodes from Patients with Cervical Cancer

(2014) A. M. Heeren et al.   Cancer Immunology Research

Subtypes of cytotoxic lymphocytes and natural killer cells infiltrating cancer nests correlate with prognosis in patients with vulvar squamous cell carcinoma

(2013) Jacek Jan Sznurkowski et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-Cell-Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects

(2013) M. F. Fransen et al.   CLINICAL CANCER RESEARCH

IL-10 Conditioning of Human Skin Affects the Distribution of Migratory Dendritic Cell Subsets and Functional T Cell Differentiation

(2013) Jelle J. Lindenberg et al.   PLoS One

Activation of the noncanonical NF- B pathway by HIV controls a dendritic cell immunoregulatory phenotype

(2012) O. Manches et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation

(2011) R. van de Ven et al.   BLOOD

The ICOS/ICOSL Pathway Is Required for Optimal Antitumor Responses Mediated by Anti-CTLA-4 Therapy

(2011) T. Fu et al.   CANCER RESEARCH

Expansion of a CD8+PD-1+ Replicative Senescence Phenotype in Early Stage CLL Patients Is Associated with Inverted CD4:CD8 Ratios and Disease Progression

(2011) C. Nunes et al.   CLINICAL CANCER RESEARCH

Expression of indoleamine 2,3-dioxygenase predicts shorter survival in patients with vulvar squamous cell carcinoma (vSCC) not influencing on the recruitment of FOXP3-expressing regulatory T cells in cancer nests

(2011) Jacek J. Sznurkowski et al.   GYNECOLOGIC ONCOLOGY

Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma

(2011) R.A. de Jong et al.   GYNECOLOGIC ONCOLOGY

Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

(2010) S Daayana et al.   BRITISH JOURNAL OF CANCER

Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study

(2010) Maaike H Oonk et al.   LANCET ONCOLOGY

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

CTLA-4 blockade increases IFN -producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients

(2008) C. I. Liakou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA