Article
Multidisciplinary Sciences
Changsheng Huang, Shengxiang Ren, Yaqi Chen, Anyi Liu, Qi Wu, Tao Jiang, Panjing Lv, Da Song, Fuqing Hu, Jingqing Lan, Li Sun, Xue Zheng, Xuelai Luo, Qian Chu, Keyi Jia, Yan Li, Jun Wang, Caicun Zou, Junbo Hu, Guihua Wang
Summary: This research discovered that PD-L1 K162 was methylated by SETD7 and demethylated by LSD2. Additionally, PD-L1 K162 methylation controlled the PD1/PD-L1 interaction and significantly enhanced the suppression of T cell activity in controlling cancer immune surveillance. The study demonstrated that PD-L1 hypermethylation was the key mechanism for anti-PD-L1 therapy resistance, identified PD-L1 K162 methylation as a negative predictive marker for anti-PD-1 treatment in patients with non-small cell lung cancer, and showed that the PD-L1 K162 methylation:PD-L1 ratio was a more accurate biomarker for predicting anti-PD-(L)1 therapy sensitivity.
Review
Immunology
Qian Li, Jingjing Han, Yonglin Yang, Yu Chen
Summary: Hepatocellular carcinoma (HCC) has a high prevalence and mortality rate worldwide. In recent years, immunotherapy using immune checkpoint inhibitors, particularly targeting the PD-1/PD-L1 axis, has brought fundamental changes to the treatment of advanced HCC. However, challenges remain and combination therapy may be a better option to improve the low remission rate.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Tianyu Wang, Shi Cai, Yao Cheng, Wanheng Zhang, Minmin Wang, Huiyong Sun, Binghua Guo, Zheng Li, Yibei Xiao, Sheng Jiang
Summary: Compound 17 is a bifunctional inhibitor that can block the interactions between PD-1 and PD-L1, promoting internalization and degradation of PD-L1. It effectively suppresses tumor growth in vivo by activating antitumor immunity.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Oncology
David Johnson, Brigette B. Y. Ma
Summary: The upregulation of the PD-1/PD-L1 pathway is a possible immune-evasion mechanism in Epstein-Barr virus-associated nasopharyngeal cancer (NPC). Therapeutic targeting of this pathway is actively researched in NPC, with multiple monoclonal antibodies currently under evaluation in clinical settings. Combinatorial strategies involving cytotoxic chemotherapy, radiotherapy, and other immunotherapeutic agents are also being explored in clinical trials for NPC.
Review
Nutrition & Dietetics
Yuqian Wang, Lingeng Lu, Changquan Ling, Ping Zhang, Rui Han
Summary: This study proposes a novel therapeutic strategy for breast cancer treatment by combining a diet containing HDAC2 inhibitors with PD-1/PD-L1 inhibitors, offering promising possibilities for improving treatment outcomes.
Review
Immunology
Youliang Zhao, Yaqian Qu, Changfu Hao, Wu Yao
Summary: Fibrosis is a pathological process characterized by excessive accumulation of extracellular matrix, leading to permanent scarring and organ failure. The immune system, particularly the immune checkpoint molecule PD-1/PD-L1 axis, plays a crucial role in the initiation and progression of fibrosis. The therapeutic targeting of PD-1/PD-L1 axis for tumor immunotherapy has provided new insights for its potential use in fibrotic diseases. This review discusses the structure, function, and regulatory mechanism of PD-1 and PD-L1, and summarizes the research progress of PD-1/PD-L1 signaling in fibrotic diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yunzhou Pu, Qing Ji
Summary: This review summarizes the roles and mechanisms of tumor-associated macrophages (TAMs) in the resistance of PD-1/PD-L1 inhibitors. Various therapies, including inhibition of TAM differentiation and re-education of TAM activation, are available to recover the anticancer efficacy of PD-1/PD-L1 inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Marton Gyulai, Zsolt Megyesfalvi, Lilla Reiniger, Tunde Harko, Bence Ferencz, Luca Karsko, Laszlo Agocs, Janos Fillinger, Balazs Dome, Zoltan Szallasi, Judit Moldvay
Summary: This study aimed to assess the potential role of immunotherapy in rare lung tumors. Immunohistochemical staining detected the expression of PD-L1 and PD-1 in mucoepidermoid carcinomas, adenoid cystic carcinomas, and tracheobronchial papillomas. A strong PD-L1 immunopositivity was observed in one mucoepidermoid carcinoma sample, indicating a need for further investigation.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Zelei Dai, Nian Li, Jun Wang, Chenfeng Tan, Yonggang Zhang, Lei Liu
Summary: This study provides a comprehensive analysis of registered clinical trials related to anti-PD-1/PD-L1 for nasopharyngeal carcinoma on ClinicalTrials.gov. The majority of trials are in the recruitment phase, with PD-1 inhibitors being preferred over PD-L1, and Toripalimab emerging as the most extensively studied drug.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Jerry Polesel, Anna Menegaldo, Giancarlo Tirelli, Vittorio Giacomarra, Roberto Guerrieri, Lorena Baboci, Mariateresa Casarotto, Valentina Lupato, Giuseppe Fanetti, Paolo Boscolo-Rizzo, Elisabetta Fratta
Summary: The expression of PD-L1 in OPSCC is associated with improved survival, particularly benefiting HPV-positive OPSCC patients compared to their negative counterparts. PD-L1 may serve as a valuable biomarker to stratify prognosis in OPSCC alongside HPV status.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jinhua Liu, Zichao Chen, Yaqun Li, Wenjie Zhao, JiBiao Wu, Zhen Zhang
Summary: Programmed death protein 1 (PD1) is an important immune checkpoint on T cells that plays a crucial role in downregulating the immune system and promoting self-tolerance, while its ligand, programmed cell death ligand 1 (PDL1), is overexpressed in malignant tumor cells, contributing to immune evasion and treatment failure. Despite the clinical efficacy of PD1/PDL1 inhibitors in many tumors, some patients may develop drug resistance, highlighting the need for further research into improving targeted therapies and understanding the associated safety issues.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Xuan Zhao, Yulin Bao, Bi Meng, Zijian Xu, Sijin Li, Xu Wang, Rui Hou, Wen Ma, Dan Liu, Junnian Zheng, Ming Shi
Summary: Developing biomarkers for predicting the efficacy of immune checkpoint inhibitor therapies is important for avoiding side effects and economic burden. Current assays evaluating PD-L1 expression are imperfect, but recent studies are advancing the methodologies to improve accuracy. This includes standardization of immunohistochemistry tests and the use of novel in vivo probes and liquid biopsy. Considering PD-L1 expression on non-tumor cells and utilizing artificial intelligence can further enhance the predictive accuracy of PD-L1 as a biomarker.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Teh-Wei Wang, Yoshikazu Johmura, Narumi Suzuki, Satotaka Omori, Toshiro Migita, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa, Akihiko Yoshimura, Makoto Nakanishi
Summary: The accumulation of senescent cells is a major cause of age-related inflammation and diseases. This study reveals that senescent cells heterogeneously express the immune checkpoint protein PD-L1 and that PD-L1(+) cells accumulate with age. PD-L1(-) cells are sensitive to T-cell surveillance, while PD-L1(+) cells are resistant. The expression of PD-L1 correlates with higher levels of SASP.
Review
Immunology
Mengke Niu, Yiming Liu, Ming Yi, Dechao Jiao, Kongming Wu
Summary: The immune checkpoint pathway involving PD-1 and PD-L1 plays a crucial role in inhibiting T-cell proliferation and function, affecting antitumor immune responses. Alternative forms of PD-1/PD-L1, such as sPD-1/sPD-L1 and exoPD-L1, have been detected in cancer patients and may have significant biological activities.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Quanqing Tang, Shihao Li, Gaozhen Huang, Hongwei Liu
Summary: Urothelial carcinoma (UC) is a common malignant tumor. Platinum-based chemotherapy has been the standard treatment for metastatic UC, but immune checkpoint inhibitors (ICIs) offer hope for patients unfit for platinum therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lena Ludwar, Hilke Mannel, Stefanie Hamacher, Michael Johannes Noack, Anna Greta Barbe
Summary: Oil pulling can alleviate medication-induced xerostomia symptoms, but there is no significant difference in symptom relief compared to water. Oil pulling reduces the overall xerostomic burden, making swallowing easier, providing a pleasant mouthfeel, and reducing nighttime awakening. Oil pulling can be considered as a cost-effective and easily accessible alternative for short-term symptom relief.
Article
Medicine, General & Internal
M. Scherner, C. Weber, H. Schmidt, K. Kuhr, S. Hamacher, A. Sabashnikov, K. Eghbalzadeh, N. Mader, T. Wahlers, J. Wippermann
Summary: Urgent coronary artery bypass graft (U-CABG) surgery is associated with a higher incidence of postoperative acute kidney injury (AKI) and mortality compared to elective CABG. Higher AKI stages (2 + 3) are strongly correlated with mortality, and preoperative renal impairment, peripheral vascular disease, and transfusion of more than two red blood cell concentrates are predictors of postoperative AKI.
MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN
(2022)
Article
Psychology, Developmental
Heidrun Lioba Wunram, Stefanie Hamacher, Max Oberste, Susanne Neufang, Luisa Belke, Franziska Jaenicke, Christine Graf, Eckhard Schoenau, Stephan Bender, Oliver Fricke
Summary: Recent meta-analyses have shown a moderate effect of physical activity in treating adolescent depression. Positive prior sports experiences and motivational factors, such as beliefs, expectancies, and enjoyment related to physical activity, can increase the effectiveness of exercise therapy in juvenile depression. Motivational placebo-related factors significantly influence the outcomes of exercise treatment, with a neutral mindset being sufficient to benefit more from physical activity.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Obstetrics & Gynecology
Alina Katharina Jansen, Sebastian Ludwig, Wolfram Malter, Axel Sauerwald, Jens Hachenberg, Caroline Pahmeyer, Kilian Wegmann, Claudia Rudroff, Leonidas Karapanos, Julia Radosa, Nadja Trageser, Christian Eichler
Summary: The study aimed to investigate the biomechanical properties of three different fixation methods for PVDF-tapes in the context of apical fixations. Results showed that PVDF-tape fixation with two single sutures can endure significantly more load compared to titanium tacks arranged in a row or in a triangle. Sutures are therefore considered a stronger and more cost-effective method for PVDF-tape fixation.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Health Care Sciences & Services
Karlotta Schloesser, Anja Bergmann, Yvonne Eisenmann, Berenike Pauli, Martin Hellmich, Max Oberste, Stefanie Hamacher, Armin Tuchscherer, Konrad F. Frank, Winfried Randerath, Simon Herkenrath, Steffen T. Simon
Summary: This study evaluated the feasibility, safety, and acceptability of a brief cognitive and behavioral intervention for the management of episodic breathlessness. The intervention and study procedures were found to be feasible, safe, and well accepted by patients. Patients showed improved mastery of breathlessness after the intervention.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Oncology
Fabinshy Thangarajah, Jana Busshoff, Janina Salamon, Marie-Sandrine Pruss, Caroline Lenz, Bernd Morgenstern, Martin Hellmich, Hans Anton Schloesser, Maximilian Lenz, Christian Domroese, Michael R. Mallmann, Peter Mallmann, Jonathan Weiss, Fabian Franzen, Sabine Merkelbach-Bruse, Elke Binot, Marie-Lisa Eich, Reinhardt Buettner, Anne Maria Schultheis, Christina Alidousty
Summary: The aim of this study was to evaluate the use of circulating cell-free HPV DNA (ccfHPV-DNA) assessed by droplet digital PCR (ddPCR) as a biomarker for molecular therapy monitoring in early, advanced, relapsed, and metastatic HPV-driven cervical and vulvar cancer. The results showed that the detection of ccfHPV-DNA can reflect treatment response and is particularly feasible in advanced stages of cervical and vulvar cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Ludwig Sebastian, Jansen Alina, Thangarajah Fabinshy, Ratiu Dominik, Sauerwald Axel, Hachenberg Jens, Wegmann Kilian, Rudroff Claudia, Karapanos Leonidas, Radosa Julia, Trageser Nadja, Eichler Christian
Summary: This study evaluated the biomechanical differences of using sutures, non-absorbable tacks, and absorbable tacks to fix polyvinylidene-fluoride tapes in an in vitro model. The results showed that the fixation with sutures can support a higher maximum load compared to non-absorbable tacks and absorbable tacks.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Pia Nottebohm, Daniel Dumitrescu, Stefanie Hamacher, Christopher Hohmann, Navid Madershahian, Stephan Baldus, Hannes Reuter, Marcel Halbach
Summary: Baroreflex activation therapy has a beneficial effect on heart failure patients, improving exercise capacity and New York Heart Association class and walk distance.
THERAPEUTIC ADVANCES IN CARDIOVASCULAR DISEASE
(2022)
Meeting Abstract
Obstetrics & Gynecology
S. Ludwig, F. Thangarajah, J. Jeschke, C. Vogel, B. Morgenstern, P. Mallmann
GEBURTSHILFE UND FRAUENHEILKUNDE
(2022)
Meeting Abstract
Obstetrics & Gynecology
S. Ludwig, F. Thangarajah, C. Vogel, J. Jeschke, P. Mallmann
GEBURTSHILFE UND FRAUENHEILKUNDE
(2022)
Meeting Abstract
Obstetrics & Gynecology
S. Ludwig, A. Jansen, N. Trageser, F. Thangarajah, C. Vogel, J. Jeschke, P. Mallmann, C. Eichler
GEBURTSHILFE UND FRAUENHEILKUNDE
(2022)
Article
Medicine, Research & Experimental
Jens Hachenberg, Lena Steinkasserer, Wolfram Malter, Fabinshy Thangarajah, Mathias Warm, Axel Gossmann, Markus Brod, Caroline Pahmeyer, Christian Eichler
Summary: This retrospective study analyzed 1,641 patients who received MRI examination at the radiological department of the municipal hospital Holweide in 2012 and 2013. The results showed that BI-RADS 4 lesions have a low probability of malignancy, and simultaneous open biopsy can be offered if there are other indications for surgery.
Article
Medicine, Research & Experimental
Oana Ratiu, Dominik Ratiu, Peter Mallmann, Alexander Di Liberto, A. Kubilay Ertan, Bernd Morgenstern, Michael R. Mallmann, Sebastian Ludwig, Berthold Gruettner, Christian Eichler, Fabinshy Thangarajah, Elena Gilman, Judith S. Abel
Summary: This study compared the effects of two different protocols of orally administered misoprostol for labor induction. It found that a higher dosage protocol significantly reduced the time from induction to delivery without increasing the risk of adverse maternal or fetal outcomes.
Article
Obstetrics & Gynecology
Christian Eichler, Jens Uener, Fabinshy Thangarajah, Julia Radosa, Max Zinser, Lotta Ada Fischer, Julian Puppe, Matthias Warm, Wolfram Malter, Caroline Lenz
Summary: This study provides long-term data on the oncologic safety of using PRP products in breast cancer patients. The results suggest that PRP application after removal of subcutaneous access devices does not have any negative impact on cancer recurrence and may improve overall survival.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)