Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 68, Issue 10, Pages 1681-1688Publisher
SPRINGER
DOI: 10.1007/s00262-019-02330-y
Keywords
Tumor-draining lymph node; Local immunotherapy; Cervical cancer; Melanoma; Breast cancer; TIMO 2018
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Funding
- Dutch Cancer Society (KWF Kankerbestrijding) [VU 2013-6015, VU 2015-7864]
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Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Here, we review our findings from translational studies in melanoma, breast, and cervical cancer and discuss clinical opportunities for local immune modulation of TDLN in each of these indications.
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