Review
Cell Biology
Vaishali Bhardwaj, Stephen M. M. Ansell
Summary: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells composed of pathologically activated neutrophils and monocytes that negatively regulate the immune response to cancer and chronic infections. They exhibit distinct characteristics and exert strong immunosuppressive effects on T-cells and other immune cells, making them a major obstacle to cancer immunotherapies. However, the clinical outcomes of targeting MDSCs in hematological malignancies, particularly B-cell malignancies, still require further exploration. This review provides a comprehensive summary of the complex biology and immunosuppressive pathways of MDSCs, with a focus on their role in modulating T-cell function in hematological malignancies, and discusses the challenges, therapeutic strategies, and clinical relevance of targeting MDSCs in these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Shweta Joshi, Andrew Sharabi
Summary: This review discusses the role of MDSCs in tumor growth, their interaction with NK cells, and the impact on NK cell-based immunotherapies, presenting strategies to enhance NK cell cytotoxicity.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Immunology
Xidan Gao, Hongshu Sui, Shang Zhao, Xingmei Gao, Yanping Su, Peng Qu
Summary: MDSCs, a heterogeneous population of immature myeloid cells accumulating in tumor-bearing hosts, play a critical role in promoting tumor immune escape. Therapeutic strategies targeting MDSCs have shown potential in enhancing the efficacy of tumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Article
Oncology
Yu Chen, Yanquan Xu, Huakan Zhao, Yu Zhou, Jiangang Zhang, Juan Lei, Lei Wu, Mingyue Zhou, Jingchun Wang, Shuai Yang, Xiao Zhang, Guifang Yan, Yongsheng Li
Summary: Cancer immunotherapy targeting myeloid-derived suppressor cells (MDSCs) is a promising anti-cancer strategy. This study explored the regulatory mechanisms of cholesterol metabolic reprogramming in MDSCs and found that cholesterol deficiency increased the immunosuppressive activity of MDSCs. Mechanistically, cholesterol elimination induced nuclear accumulation of LXR beta and enhanced the binding of LXR beta-RXR alpha on Arg1 promoter. Furthermore, itraconazole improved MDSC immunosuppressive activity and promoted tumor growth by inhibiting the RIPK3-AKT-mTORC1 pathway and impeding cholesterol synthesis.
Article
Oncology
Andrea Gaissler, Jonas Bochem, Janine Spreuer, Shannon Ottmann, Alexander Martens, Teresa Amaral, Nikolaus Benjamin Wagner, Manfred Claassen, Friedegund Meier, Patrick Terheyden, Claus Garbe, Thomas Eigentler, Benjamin Weide, Graham Pawelec, Kilian Wistuba-Hamprecht
Summary: This study investigated potential cellular biomarkers in patients with stage IV M1c melanoma undergoing immune checkpoint blockade (ICB). It was found that elevated baseline monocytic MDSC frequencies were associated with poorer outcomes, but a subgroup of patients with rapidly decreasing MDSC frequencies during therapy showed better prognosis, suggesting an imperfect correlation between high baseline MDSCs and patient outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Byung-Seok Kim, Da-Sol Kuen, Choong-Hyun Koh, Hyung-Don Kim, Seon Hee Chang, Sehui Kim, Yoon Kyung Jeon, Young-Jun Park, Garam Choi, Jiyeon Kim, Keon Wook Kang, Hye Young Kim, Suk-Jo Kang, Shin Hwang, Eui-Cheol Shin, Chang-Yuil Kang, Chen Dong, Yeonseok Chung
Summary: IL-17-producing cells promote terminal exhaustion of CD8(+) T cells and tumor progression in vivo, which can be reversed by blockade of IL-17 or ROR gamma t pathway. Human TCGA analyses reveal a strong positive correlation between type 17 and CD8(+) T cell exhaustion signature gene sets in multiple cancers, suggesting type 17 immunity as a promising target for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Ge Song, Yue Zhang, Jie Tian, Jie Ma, Kai Yin, Huaxi Xu, Shengjun Wang
Summary: Myeloid-derived suppressor cells (MDSCs) are a major component of tumor-induced immunosuppressive environment, and TRAF6 plays a critical role in modulating the immunosuppressive function of MDSCs by mediating K63-linked polyubiquitination and phosphorylation of STAT3. The abnormal accumulation of MDSCs in the peripheral blood of lung cancer patients, with highly expressed TRAF6 and arginase 1, suggests a potential target for antitumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Yanan Li, Hongdan He, Ribu Jihu, Junfu Zhou, Rui Zeng, Hengxiu Yan
Summary: MDSCs are a heterogeneous group of cells generated in various pathologic conditions, known to be key components of the tumor microenvironment promoting tumor growth, and partially restoring antitumor immunity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Xinghang Dai, Long Ren, Mengxi Liu, Hao Cai, Hu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: MDSCs have been explored as an important immunotherapeutic target in cancer immunology, and nanomedicines have shown potential in reversing immunosuppressive tumors into immunoresponsive ones to enhance therapeutic efficacy.
Review
Immunology
Yang Zhao, Junfeng Du, Xiaofei Shen
Summary: Myeloid-derived suppressor cells (MDSCs) are a major negative regulator in tumor microenvironment (TME) by inhibiting immune response and promoting immunosuppression. This review focuses on the features of MDSCs in TME and potential targets for tumor immunotherapy. Therapies aiming to reprogram TME, prevent MDSC immunosuppression, promote MDSC differentiation, and impact MDSC recruitment and abundance in tumor site are discussed. Combinatorial strategies to improve clinical efficacy and outcomes of cancer patients through better understanding of MDSCs generation and suppression in TME are also summarized.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Anik Pramanik, Sankar Bhattacharyya
Summary: The MDSC population in the tumor microenvironment plays a crucial role in tumor immune evasion and cancer progression by disrupting antitumor T cell activity and potentially affecting other immune cell functions.
Article
Oncology
Aram Lee, Haesun Park, Soyoung Lim, Jihyun Lim, Jaemoon Koh, Yoon Kyung Jeon, Young Yang, Myeong-Sok Lee, Jong-Seok Lim
Summary: This study investigated the role of MITF in immunosuppressive myeloid cells, including MDSCs. The results showed that MITF plays an important regulatory role in tumor development through its impact on the differentiation and function of MDSCs. This finding provides a basis for the development of novel therapeutic targets for modulating MDSC activity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Marco Cozzolino, Adrienn Gyongyosi, Eva Korpos, Peter Gogolak, Muhammad Umair Naseem, Judit Kallai, Arpad Lanyi, Gyorgy Panyi
Summary: Myeloid-derived suppressor cells (MDSCs) play a key role in the immunosuppressive microenvironment of tumors. This study investigated the ion channel repertoire in tumor-derived PMN-MDSC and Mo-MDSCs, and found that Hv1 H+ channel is expressed in both types of MDSCs. Hv1 might be a potential target for inhibiting MDSCs in tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ariane A. van Loevezijn, Marieke E. M. van der Noordaa, Erik D. van Werkhoven, Claudette E. Loo, Gonneke A. O. Winter-Warnars, Terry Wiersma, Koen K. van de Vijver, Emilie J. Groen, Charlotte F. J. M. Blanken-Peeters, Bas J. G. L. Zonneveld, Gabe S. Sonke, Frederieke H. van Duijnhoven, Marie-Jeanne T. F. D. Vrancken Peeters
Summary: The study found that ultrasound-guided core biopsies are not accurate enough to identify breast pCR in patients with good response on MRI after neoadjuvant systemic therapy. Therefore, breast surgery cannot be safely omitted based solely on the results of core biopsies in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Correction
Pathology
J. O. A. M. van Baal, C. A. R. Lok, E. S. Jordanova, H. Horlings, W. J. van Driel, F. C. Amant, K. K. Van de Vijver
Article
Pathology
Shatavisha Dasgupta, Elf de Jonge, Mieke R. Van Bockstal, Luthy S. M. Wong-Alcala, Suzanne Wilhelmus, Lex A. C. F. Makkus, Katrien Schelfout, Koen K. Van de Vijver, Sander Smits, Etienne Marbaix, Senada Koljenovic, Folkert J. van Kemenade, Patricia C. Ewing-Graham
Summary: Differentiated vulvar intraepithelial neoplasia (dVIN) is a premalignant lesion with potential to progress rapidly to invasive carcinoma. A study on inter-observer agreement in the histological assessment of dVIN identified helpful diagnostic features such as parakeratosis, cobblestone appearance, and chromatin abnormality. Consensus-based pathological evaluation may improve the reliability of diagnosing dVIN cases with histological suspicion.
Review
Medicine, General & Internal
Ellen Deolet, Jo Van Dorpe, Koen Van de Vijver
Summary: Mesonephric-like adenocarcinoma is a rare and challenging subtype of endometrial cancer, often misdiagnosed and associated with early local recurrence and metastasis. Comprehensive analysis using histopathological, immunohistochemical, and molecular techniques can provide better understanding of this rare cancer. Advanced diagnostic methods are crucial in developing new therapeutic strategies against this aggressive subtype of endometrial cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Cell Biology
Sasha Libbrecht, Jolien Van Cleemput, Linos Vandekerckhove, Sofie Colman, Elizaveta Padalko, Bruno Verhasselt, Koen van de Vijver, Amelie Dendooven, Isabelle Dehaene, Jo Van Dorpe
Review
Medicine, General & Internal
Aglaja De Pauw, Eline Naert, Koen Van de Vijver, Tummers Philippe, Katrien Vandecasteele, Hannelore Denys
Summary: OCCC is a less common subtype of ovarian cancer with distinct clinical behavior and molecular alterations. Patients with OCCC have worse outcomes compared to high grade serous carcinomas. Research specific to this subtype is needed to improve patient outcomes.
ACTA CLINICA BELGICA
(2022)
Article
Oncology
Lilian van Wagensveld, Gabe Steven Sonke, Koen Kris Van de Vijver, Hugo Mark Horlings, Rutgerus Franciscus Petrus Maria Kruitwagen, Maaike Anne van der Aa
Summary: This study aimed to identify characteristics associated with long-term survival in advanced stage EOC patients. Factors such as age, tumor stage, histology, surgery type, chemotherapy cycles, and disease residual status were found to be significantly correlated with LTS.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2022)
Article
Oncology
Simone N. Koole, Philip C. Schouten, Jan Hauke, Roel J. C. Kluin, Petra Nederlof, Lisa K. Richters, Gabriele Krebsbach, Karolina Sikorska, Maartje Alkemade, Mark Opdam, Jules H. Schagen van Leeuwen, Henk W. R. Schreuder, Ralph H. M. Hermans, Ignace H. J. T. de Hingh, Constantijne H. Mom, Henriette J. G. Arts, Maaike van Ham, Peter van Dam, Peter Vuylsteke, Joyce Sanders, Hugo M. Horlings, Koen K. van de Vijver, Eric Hahnen, Willemien J. van Driel, Rita Schmutzler, Gabe S. Sonke, Sabine C. Linn
Summary: The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin to interval cytoreductive surgery improves recurrence-free and overall survival in patients with stage III ovarian cancer. HRD ovarian tumors, especially HRD/BRCAwt and non-HRD/BRCAwt tumors, respond best to treatment with HIPEC.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nuffel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stephanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwe, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frederic Amant, Katrien Vandecasteele, Hannelore G. Denys
Summary: The PRIMMO study conducted a phase II trial on patients with pretreated persistent/recurrent/metastatic cervical or endometrial cancer. The study found that pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail had modest but durable antitumor activity, with acceptable but not negligible toxicity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Oncology
Marc D. Algera, Willemien J. van Driel, Koen K. van de Vijver, Roy F. P. M. Kruitwagen, Christianne A. R. Lok
Summary: Infiltrative and expansile subtypes of mucinous ovarian cancers have different characteristics and risks of metastasis. It is recommended to perform peritoneal staging and lymph node sampling for early-stage infiltrative MOC patients, but peritoneal staging can be safely omitted in early-stage expansile MOC patients due to rare peritoneal metastases.
CURRENT OPINION IN ONCOLOGY
(2022)
Article
Cell Biology
Jobran M. Moshi, Monique Ummelen, Jos L. Broers, Frank Smedts, Koen K. Van de Vijver, Jack P. M. Cleutjens, Rogier J. N. T. M. Litjens, Frans C. S. Ramaekers, Anton H. N. Hopman
Summary: SOX2 expression is increased in high-grade cervical intraepithelial neoplasia and cervical squamous cell carcinoma compared to normal cervical epithelium. The expression pattern of SOX2 changes during the progression of CIN, with increased expression in the intermediate/superficial compartment. A specific expression pattern is found in CIN2 and CIN3, which is significantly associated with CIN3 and contains HPV-positive cells in the basal/parabasal compartment. This study provides new insights into the pathogenesis and dynamics of premalignant cervical lesions and the target cells for HPV infection.
HISTOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Oncology
Eun-Young Kang, Ashley Weir, Nicola S. Meagher, Kyo Farrington, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Adelyn Bolithon, Gordana Popovic, Betty Leung, Katrina Tang, Neil Lambie, Joshua Millstein, Jennifer Alsop, Michael S. Anglesio, Beyhan Ataseven, Ellen Barlow, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Hans Boesmueller, Jessica Boros, Alison H. Brand, Angela Brooks-Wilson, Sara Y. Brucker, Michael E. Carney, Yovanni Casablanca, Alicia Cazorla-Jimenez, Paul A. Cohen, Thomas P. Conrads, Linda S. Cook, Penny Coulson, Madeleine Courtney-Brooks, Daniel W. Cramer, Philip Crowe, Julie M. Cunningham, Cezary Cybulski, Kathleen M. Darcy, Mona A. El-Bahrawy, Esther Elishaev, Ramona Erber, Rhonda Farrell, Sian Fereday, Anna Fischer, Maria J. Garcia, Simon A. Gayther, Aleksandra Gentry-Maharaj, C. Blake Gilks, Marcel Grube, Paul R. Harnett, Shariska Petersen Harrington, Philipp Harter, Arndt Hartmann, Jonathan L. Hecht, Sebastian Heikaus, Alexander Hein, Florian Heitz, Joy Hendley, Brenda Y. Hernandez, Susanna Hernando Polo, Sabine Heublein, Akira Hirasawa, Estrid Hogdall, Claus K. Hogdall, Hugo M. Horlings, David G. Huntsman, Tomasz Huzarski, Andrea Jewell, Mercedes Jimenez-Linan, Michael E. Jones, Scott H. Kaufmann, Catherine J. Kennedy, Dineo Khabele, Felix K. F. Kommoss, Roy F. P. M. Kruitwagen, Diether Lambrechts, Nhu D. Le, Marcin Lener, Jenny Lester, Yee Leung, Anna Linder, Liselore Loverix, Jan Lubinski, Rashna Madan, G. Larry Maxwell, Francesmary Modugno, Susan L. Neuhausen, Alexander Olawaiye, Siel Olbrecht, Sandra Orsulic, Jose Palacios, Celeste Leigh Pearce, Malcolm C. Pike, Carmel M. Quinn, Ganendra Raj Mohan, Cristina Rodriguez-Antona, Matthias Ruebner, Andy Ryan, Stuart G. Salfinger, Naoko Sasamoto, Joellen M. Schildkraut, Minouk J. Schoemaker, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Naveena Singh, Gabe S. Sonke, Linda Steele, Colin J. R. Stewart, Karin Sundfeldt, Anthony J. Swerdlow, Aline Talhouk, Adeline Tan, Sarah E. Taylor, Kathryn L. Terry, Aleksandra Toloczko, Nadia Traficante, Koen K. Van de Vijver, Maaike A. van der Aa, Toon Van Gorp, Els Van Nieuwenhuysen, Lilian Van-Wagensveld, Ignace Vergote, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Anna H. Wu, Javier Benitez, Andrew Berchuck, Francisco J. Candido Dos Reis, Anna DeFazio, Peter A. Fasching, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, Beth Y. Karlan, Stefan Kommoss, Usha Menon, Hans-Peter Sinn, Annette Staebler, James D. Brenton, David D. Bowtell, Paul D. P. Pharoah, Susan J. Ramus, Martin Kobel
Summary: This study validates that high-level amplification of CCNE1 is associated with shorter survival in tubo-ovarian high-grade serous carcinoma (HGSC), supporting its use as a prognostic biomarker in this disease.
Article
Oncology
Lilian van Wagensveld, Juliette O. A. M. van Baal, Maite Timmermans, Duco Gaillard, Lauri Borghuis, Seth B. Coffelt, Efraim H. Rosenberg, Christianne A. R. Lok, Hans W. Nijman, Loes F. S. Kooreman, Joyce Sanders, Marco de Bruijn, Lodewyk F. A. Wessels, Rianne van der Wiel, Christian Rausch, Annegien Broeks, Roy F. P. M. Kruitwagen, Maaike A. van der Aa, Gabe S. Sonke, Philip C. Schouten, Koen K. van de Vijver, Hugo M. Horlings
Summary: Ovarian cancer is a deadly gynecological cancer, and high-grade serous ovarian carcinoma (HGSOC) is the most common subtype. This study investigated the associations between the tumor microenvironment (TME), genetic profiles, and overall survival (OS) in HGSOC. The results showed that HGSOC can be categorized into different entities based on molecular profiles and TME. Higher immune cell densities in the TME were associated with better survival, regardless of the molecular profiles.
Article
Oncology
Menekse Goker, Stephanie Deblaere, Hannelore Denys, Glenn Vergauwen, Eline Naert, Liv Veldeman, Chris Monten, Rudy Van den Broecke, Jo Van Dorpe, Geert Braems, Koen Van de Vijver
Summary: This study investigated the expression of sTILs and PD-L1 in pleomorphic invasive lobular cancer (pILC). It found that sTILs were present in the majority of pILC patients, while PD-L1 expression was not associated with survival improvement.
Review
Radiology, Nuclear Medicine & Medical Imaging
Anne-Sofie De Crem, Koen van de Vijver, Pieter De Visschere, Rudy Van den Broecke, Menekse Goker
Summary: Amyloidosis is a rare disorder characterized by the accumulation of misfolded proteins outside cells in tissues. This unique case study reports on a 56-year-old woman with systemic lupus erythematosus who had localized breast amyloidosis presenting as suspicious microcalcifications but no mass on mammography. Biopsy confirmed the diagnosis, and follow-up is recommended to exclude systemic amyloidosis or hematologic malignancy.
JOURNAL OF THE BELGIAN SOCIETY OF RADIOLOGY
(2022)