Article
Oncology
Linn Woelber, Mareike Bommert, Philipp Harter, Katharina Prieske, Christine zu Eulenburg, Julia Jueckstock, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Matthias Beckmann, Alexander Mustea, Werner Meier, Sven Mahner, Anna Jaeger
Summary: The study suggests that pelvic nodal staging may be unnecessary for the majority of node-positive patients with VSCC, as relevant risk for pelvic nodal involvement seems to be present only in highly node-positive disease.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Linn Woelber, Katharina Prieske, Christine zu Eulenburg, Stefanie Corradini, Cordula Petersen, Mareike Bommert, Thomas Blankenstein, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Matthias W. Beckmann, Alexander Mustea, Sven Mahner, Anna Jaeger
Summary: Adjuvant radiotherapy to the vulva reduces the risk of local recurrence in patients with vulvar squamous cell cancer, particularly in HPV-positive patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Sarah Ashmore, Sarah M. Crafton, Eirwen M. Miller, Thomas C. Krivak, Scott M. Glaser, Solomiya R. Teterichko, Paniti Sukumvanich, Akila N. Viswanathan, Sushil Beriwal, Zachary D. Horne
Summary: The study found that overall treatment time (OTT) is associated with overall survival (OS) in women with completely resected, node-positive squamous cell carcinomas of the vulva. Shorter OTT was related to factors like age and facility volume, and each additional day of OTT was associated with a 0.4% increased risk of death.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Zeynep Eroglu, Kristy K. Broman, John F. Thompson, Amanda Nijhuis, Tina J. Hieken, Lisa Kottschade, Jeffrey M. Farma, Meghan Hotz, Jeremiah Deneve, Martin Fleming, Edmund K. Bartlett, Avinash Sharma, Lesly Dossett, Tasha Hughes, David E. Gyorki, Jennifer Downs, Giorgos Karakousis, Yun Song, Ann Lee, Russell S. Berman, Alexander van Akkooi, Emma Stahlie, Dale Han, John Vetto, Georgia Beasley, Norma E. Farrow, Jane Yuet Ching Hui, Marc Moncrieff, Jenny Nobes, Kirsten Baecher, Matthew Perez, Michael Lowe, David W. Ollila, Frances A. Collichio, Roger Olofsson Bagge, Jan Mattsson, Hidde M. Kroon, Harvey Chai, Jyri Teras, James Sun, Michael J. Carr, Ankita Tandon, Nalan Akgul Babacan, Younchul Kim, Mahrukh Naqvi, Jonathan Zager, Nikhil Khushalani
Summary: Most patients with SLN+ melanoma no longer undergo a completion lymph node dissection (CLND) prior to adjuvant systemic therapy. The omission of immediate CLND in these patients may increase the risk of nodal relapse, but salvage surgery with therapeutic lymph node dissection (TLND) at relapse may be a viable option for these patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Surgery
Vignesh Raman, Oliver K. Jawitz, Norma E. Farrow, Soraya L. Voigt, Kristen E. Rhodin, Chi-Fu J. Yang, Megan C. Turner, Thomas A. D'Amico, David H. Harpole, Betty C. Tong
Summary: In this study of patients with upfront, complete resection of node-positive esophageal adenocarcinoma, adjuvant chemotherapy was associated with improved survival for LNR >=12%. LNR may be used as an adjunct in decision-making about adjuvant therapies in this patient population.
Article
Oncology
Kristy K. Broman, Deepti Bettampadi, Jaileene Perez-Morales, James Sun, Dennis Kirichenko, Michael J. Carr, Zeynep Eroglu, Ahmad A. Tarhini, Nikhil Khushalani, Matthew B. Schabath, Amod Sarnaik, Vernon K. Sondak, Jonathan S. Zager
Summary: The study found that regardless of adjuvant treatment, most nodal recurrences occur in the first year and are initially detected clinically or by ultrasound. The results support the continued use of examination and nodal basin ultrasound alongside any planned cross-sectional imaging surveillance.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Lisa Ni, Sumi Sinha, Marianne Rara, Christina Phuong, Lee-May Chen, I-Chow J. Hsu, Emi J. Yoshida
Summary: This NCDB study suggests that in older patients with node-positive vulvar cancer, radiotherapy continues to be a vital component of multimodality therapy. However, a comprehensive and geriatrics-specific approach is crucial for treating older adults with node-positive vulvar cancer, as the benefit of adjuvant radiotherapy may be compromised by treatment-related morbidity/toxicity.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Tanja Ignatov, Johannes Gassner, Mihaela Bozukova, Stylianos Ivros, Jozsef Meszaros, Olaf Ortmann, Holm Eggemann, Atanas Ignatov
Summary: The risk of contralateral non-SLN metastases in patients with unilateral SLN metastases in vulvar cancer is low, suggesting a need for further investigation into the impact of contralateral lymphadenectomy on patient survival.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Oncology
Dimitrios Nasioudis, Nayla Labban, Nawar Latif, Stefan Gysler, Lori Cory, Sarah Kim, Robert L. Giuntoli, Emily M. Ko
Summary: This study investigated the utilization and outcomes of adjuvant immunotherapy for patients with vulvar melanoma and inguinal lymph node metastases. The results showed that immunotherapy did not improve overall survival for these patients.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Surgery
Kristy M. Broman, Tasha C. Hughes, Brooke Bredbeck, James Sun, Dennis J. Kirichenko, Michael Carr, Avinash Sharma, Edmund Bartlett, Amanda A. G. Nijhuis, John F. Thompson, Tina J. Hieken, Lisa Kottschade, Jennifer Downs, David E. Gyorki, Emma Stahlie, Alexander van Akkooi, David Ollila, Kristin O'shea, Yun Song, Giorgos Karakousis, Marc Moncrieff, Jenny Nobes, John Vetto, Dale Han, Meghan Hotz, Jeffrey M. Farma, Jeremiah L. Deneve, Martin D. Fleming, Matthew Perez, Kirsten Baecher, Michael Lowe, Roger Olofsson Bagge, Jan Mattsson, Ann Y. Lee, Russell S. Berman, Harvey Chai, Hidde M. Kroon, Juri Teras, Roland M. Teras, Norma E. Farrow, Georgia M. Beasley, Jane Yuet Ching Hui, Lukas Been, Schelto Kruijff, Brandy Sinco, Amod A. Sarnaik, Vernon K. Sondak, Jonathan S. Zager, Lesly A. Dossett
Summary: The aim of this study was to determine trends and variation in the utilization of CLND and adjuvant systemic therapy for SLN-positive melanoma. The study found a decline in CLND and an increase in adjuvant systemic therapy. There was significant variation among treating centers, and location of care contributed significantly to the observed variation.
Article
Oncology
Phillip M. Kemp Bohan, Derek T. Kirby, Robert C. Chick, Julia O. Bader, G. Travis Clifton, Timothy J. Vreeland, Daniel W. Nelson
Summary: The study found that the proportion of gallbladder cancer patients receiving adjuvant chemotherapy after surgery increased from 9.9% in 2006 to 24.2% in 2015, but only 17.5% of patients actually received chemotherapy. The results showed that adjuvant chemotherapy improved overall survival for node-positive (stage IIIb) patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Shoshana M. Rosenberg, Anne O'Neill, Karen Sepucha, Kathy D. Miller, Chau T. Dang, Donald W. Northfelt, George W. Sledge, Bryan P. Schneider, Ann H. Partridge
Summary: This study aimed to describe and evaluate factors associated with diminished quality of life (QOL) following completion of breast cancer treatment. The study found that a substantial proportion of patients experienced pain, discomfort, anxiety, and depression even 18 months after treatment completion, highlighting the need for timely support and intervention. The study also identified mastectomy with radiation and certain racial factors as associated with lower QOL.
Article
Oncology
Huan Chen, Min Qu, Haoqing Shi, Zhenyang Dong, Yan Wang, Xu Gao
Summary: The purpose of this study was to determine whether immediate androgen deprivation therapy (ADT) plus radiotherapy (RT) extends survival in men with node-positive prostate cancer after radical prostatectomy compared with those who received ADT alone. The results showed that the addition of RT to ADT did not significantly improve castration-resistant prostate cancer (CRPC)-free and distant metastasis-free survival. However, patients with positive lymph nodes < 4 may benefit from ADT plus RT.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Meriem Mokhtech, Sarah J. Gao, Megan Kassick, Gulden Menderes, Shari Damast
Summary: This study utilized the National Cancer Database to investigate the treatment trends of clinically node-negative, pathologically node-positive vulvar cancer patients. The study found an increase in the use of SLNB alone and a decrease in the use of IFL +/- SLNB. Receipt of chemotherapy and radiation was associated with improved overall survival.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Maria Cristina Leonardi, Camilla Arrobbio, Sara Gandini, Stefania Volpe, Francesca Colombo, Eliana La Rocca, Viviana Galimberti, Sabrina Kahler-Ribeiro-Fontana, Cristiana Fodor, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Emilia Montagna, Marco Colleoni, Giovanni Mazzarol, Laura Lavinia Travaini, Mattia Zaffaroni, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: This study aimed to evaluate the rate of positive non-sentinel lymph nodes in breast cancer patients after neoadjuvant systemic therapy following positive sentinel lymph node biopsy. Positive non-SLNs were found in 62.3% of cases and were significantly associated with older age, clinically positive lymph nodes, SLN extracapsular extension, and a higher ratio of positive SLNs/total SLNs. ECE and higher nodal ratio were independent predictors of III axillary level positivity.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Miriam Deniz, Amelie DeGregorio, Nikolaus DeGregorio, Inga Bekes, Peter Widschwendter, Fabienne Schochter, Kristina Ernst, Christoph Scholz, Emanuel C. A. Bauer, Viktoria Aivazova-Fuchs, Tobias Weissenbacher, Bernd Kost, Julia Jueckstock, Ullrich Andergassen, Julia Steidl, Elisabeth Trapp, Peter A. Fasching, Lothar Haeberle, Matthias W. Beckmann, Andreas Schneeweiss, Iris Schrader, Wolfgang Janni, Brigitte Rack, Thomas W. P. Friedl
Article
Oncology
Stephan Polterauer, Richard Schwameis, Christoph Grimm, Peter Hillemanns, Julia Jueckstock, Felix Hilpert, Nikolaus de Gregorio, Annette Hasenburg, Jalid Sehouli, Sophie Theresa Fuerst, Hans Georg Strauss, Klaus Baumann, Falk Thiel, Alexander Mustea, Philipp Harter, Pauline Wimberger, Heinz Koelbl, Alexander Reinthaller, Linn Woelber, Sven Mahner
GYNECOLOGIC ONCOLOGY
(2019)
Article
Obstetrics & Gynecology
N. de Gregorio, A. de Gregorio, F. Ebner, T. W. P. Friedl, J. Huober, R. Hefty, M. Wittau, W. Janni, P. Widschwendter
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2019)
Meeting Abstract
Oncology
Nikolaus de Gregorio, Amelie De Gregorio, Florian Ebner, Fabienne Schochter, Thomas W. P. Friedl, Jens Bodo Huober, Wolfgang Janni, Peter Widschwendter
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Ruediger Klapdor, Peter Hillemanns, Linn Lena Woelber, Julia Kathrin Jueckstock, Felix Hilpert, Nikolaus de Gregorio, Annette Hasenburg, Jalid Sehouli, Atanas Ignatov, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Falk Thiel, Alexander Mustea, Werner Meier, Philipp Harter, Pauline Wimberger, Lars Christian Hanker, Barbara Schmalfeldt, Sven Mahner
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Arkadius A. Polasik, Wolfgang Janni, Christoph Scholz, Nikolaus De Gregorio, Fabienne Schochter, Thomas W. P. Friedl, Peter Widschwendter
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Linn Woelber, Christine Eulenburg, Jens Kosse, Petra Neuser, Christoph Heiss, Peer Hantschmann, Peter Mallmann, Berno Tanner, Jacobus Pfisterer, Julia Jueckstock, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Sven Mahner, Katharina Prieske
GYNECOLOGIC ONCOLOGY
(2019)
Article
Obstetrics & Gynecology
Amelie De Gregorio, Gabriele Nagel, Peter Moeller, Andreas Rempen, Erik Schlicht, Steffen Fritz, Felix Flock, Thorsten Kuehn, Falk Thiel, Ricardo Felberbaum, Florian Ebner, Nikolaus De Gregorio, Thomas Wolfram Paul Friedl, Lisa Wiesmueller, Peter Kuhn, Margit Schmitt, Wolfgang Janni, Dietrich Rothenbacher, Jens Huober
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2020)
Article
Obstetrics & Gynecology
P. Widschwendter, W. Janni, C. Scholz, A. De Gregorio, N. De Gregorio, T. W. P. Friedl
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2019)
Article
Oncology
Amelie de Gregorio, Peter Widschwendter, Florian Ebner, Thomas Wolfram Paul Friedl, Jens Huober, Wolfgang Janni, Nikolaus de Gregorio
Meeting Abstract
Oncology
Lars Hanker, Philipp Harter, Land Sehoul, Joern Rau, Ulrich Canzler, Barbara Schmalfeldt, Falk Thiel, Ahmed El-Balat, Frederik Marme, Nikolaus De Gregorio, Klaus Baumannn, Sven Mahner, Werner Meier, Tjoung-Won Park-Simon, Eva-Maria Grischke, Peter Hillemanns, Felix Hilpert, Hans-Joachim Lueck, Rainer Kimmig, Martina Gropp-Meier, Alexander Burges, Christian Jackisch, Willibald Schroeder, Jacobus Pfisterer
ONCOLOGY RESEARCH AND TREATMENT
(2020)
Meeting Abstract
Oncology
Nikolaus de Gregorio, Philipp Harter, Lalid Sehouli, Ulrich Canzler, Frederik Marme, Paul Buderath, Hans-Joachim Lueck, Martina Gropp-Meier, Ingo B. Runnebaum, Antje Belau, Stefan Renner, Barbara Schmalfeldt, Ahmed El-Balat, Alexander Burges, Peter Hillemanns, Dominik Denschlag, Dirk Bauerschlag, Lars Hanker, Andreas Schnelzer, Isabelle Ray-Coquard
ONCOLOGY RESEARCH AND TREATMENT
(2020)
Meeting Abstract
Oncology
R. Klapdor, P. Hillemanns, L. Woelber, J. Jueckstock, F. Hilpert, N. de Gregorio, A. Hasenburg, J. Sehouli, S. T. Fuerst, H. G. Strauss, K. Baumann, F. Thiel, A. Mustea, W. Meier, P. Harter, P. Wimberger, L. Hanker, B. Schmalfeldt, S. Mahner
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2019)
Meeting Abstract
Oncology
K. Fujiwara, P. Harter, A. Leary, D. Perol, S. Pignata, A. Gonzalez-Martin, E. Petru, E. van Nieuwenhuysen, N. Colombo, J. Maenpaa, F. Selle, N. de Gregorio, D. Lorusso, E. M. Guerra Alia, C. Lefeuvre-Plesse, P. Buderath, A. Lortholary, A. Burges, E. Pujade-Lauraine, I. L. Ray-Coquard
ANNALS OF ONCOLOGY
(2019)
Article
Obstetrics & Gynecology
Peter Widschwendter, Wolfgang Janni, Julian Benckendorff, Nikolaus de Gregorio
JOURNAL OF ENDOMETRIOSIS AND PELVIC PAIN DISORDERS
(2019)