Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60

Neuronal enhancers are hotspots for DNA single-strand break repair

(2021) Wei Wu et al.   NATURE

The central role of DNA damage in the ageing process

(2021) Björn Schumacher et al.   NATURE

Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans

(2021) Lucile Marchal et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity

(2020) Anna Wilk et al.   Scientific Reports

Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS): A Multiplexed Microarray Platform for Targeted Proteomics

(2020) Ghaith M. Hamza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells

(2020) Marcos A. Perez et al.   DEVELOPMENTAL CELL

DNA Damage Response and Metabolic Reprogramming in Health and Disease

(2020) Ourania Chatzidoukaki et al.   TRENDS IN GENETICS

NuRD mediates mitochondrial stress–induced longevity via chromatin remodeling in response to acetyl-CoA level

(2020) Di Zhu et al.   Science Advances

Accelerated aging among childhood, adolescent, and young adult cancer survivors is evidenced by increased expression of p16 INK4a and frailty

(2020) Andrew B. Smitherman et al.   CANCER

HLH-11 modulates lipid metabolism in response to nutrient availability

(2020) Yi Li et al.   Nature Communications

A Persistence Detector for Metabolic Network Rewiring in an Animal

(2019) Jote T. Bulcha et al.   Cell Reports

Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity

(2019) Prasanna V. Ramachandran et al.   DEVELOPMENTAL CELL

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

(2019) Chiara Milanese et al.   Nature Communications

WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data

(2019) Amy D. Holdorf et al.   GENETICS

Prevalence and Predictors of Frailty in Childhood Cancer Survivors and Siblings: A Report From the Childhood Cancer Survivor Study

(2019) Samah Hayek et al.   JOURNAL OF CLINICAL ONCOLOGY

Nuclear Genomic Instability and Aging

(2018) Laura J. Niedernhofer et al.   Annual Review of Biochemistry

A Metabolic Basis for Endothelial-to-Mesenchymal Transition

(2018) Jianhua Xiong et al.   MOLECULAR CELL

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation

(2018) Jing Zhao et al.   PLOS BIOLOGY

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging

(2018) Aditi U. Gurkar et al.   Redox Biology

Epigenomic drivers of immune dysfunction in aging

(2018) Christine R. Keenan et al.   AGING CELL

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Silencing of Repetitive DNA Is Controlled by a Member of an Unusual Caenorhabditis elegans Gene Family

(2017) Eduardo Leyva-Díaz et al.   GENETICS

Weight loss is a major cause of frailty

(2017) B. Fougère et al.   Journal of Nutrition Health & Aging

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

(2017) Sharanya Sivanand et al.   MOLECULAR CELL

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

(2017) Shuo Han et al.   NATURE

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans

(2017) Diletta Edifizi et al.   Cell Reports

Silencing of Repetitive DNA Is Controlled by a Member of an Unusual Caenorhabditis elegans Gene Family

(2017) Eduardo Leyva-Díaz et al.   GENETICS

LC-quadrupole/Orbitrap high-resolution mass spectrometry enables stable isotope-resolved simultaneous quantification and 13C-isotopic labeling of acyl-coenzyme A thioesters

(2016) Alexander J. Frey et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

(2016) W. P. Vermeij et al.   NATURE

An H4K16 histone acetyltransferase mediates decondensation of the X chromosome in C. elegans males

(2016) Alyssa C. Lau et al.   Epigenetics & Chromatin

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

(2016) Eoin McDonnell et al.   Cell Reports

Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture

(2015) Nathaniel W. Snyder et al.   ANALYTICAL BIOCHEMISTRY

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

(2015) Lei Shi et al.   CURRENT OPINION IN CELL BIOLOGY

Comparison of mice with accelerated aging caused by distinct mechanisms

(2015) Aditi U. Gurkar et al.   EXPERIMENTAL GERONTOLOGY

Loss of Weight in Obese Older Adults: A Biomarker of Impending Expansion of Multimorbidity?

(2015) Elisa Fabbri et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

(2015) A. Folick et al.   SCIENCE

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway

(2014) Robert Fischer et al.   JOURNAL OF LIPID RESEARCH

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

(2014) Michael M. Mueller et al.   NATURE CELL BIOLOGY

Sirtuins: guardians of mammalian healthspan

(2014) William Giblin et al.   TRENDS IN GENETICS

Lipidomics of familial longevity

(2013) Vanessa Gonzalez-Covarrubias et al.   AGING CELL

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria

(2013) Ismene Karakasilioti et al.   Cell Metabolism

Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution

(2013) Allison B. Chambliss et al.   FASEB JOURNAL

Fish oil changes the lifespan of Caenorhabditis elegans via lipid peroxidation

(2013) Soko Sugawara et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation

(2010) Padma Madiraju et al.   Epigenetics

Physical and Functional HAT/HDAC Interplay Regulates Protein Acetylation Balance

(2010) Alessia Peserico et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

(2010) G. G. Sharma et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

C. elegans Major Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles

(2009) Eyleen J. O'Rourke et al.   Cell Metabolism

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Anti-Inflammatory and Proresolving Lipid Mediators

(2008) Charles N. Serhan et al.   Annual Review of Pathology-Mechanisms of Disease

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

(2008) A. Ahmad et al.   MOLECULAR AND CELLULAR BIOLOGY