Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation

Peptide-based inhibition of IκB kinase/nuclear factor-κB pathway protects against diabetes-associated nephropathy and atherosclerosis in a mouse model of type 1 diabetes

(2015) Ainhoa Oguiza et al.   DIABETOLOGIA

Identification and Characterization of a Novel Small-Molecule Inhibitor of β-Catenin Signaling

(2014) Evan R. Delgado et al.   AMERICAN JOURNAL OF PATHOLOGY

A Phase I Clinical Trial of Systemically Delivered NEMO Binding Domain Peptide in Dogs with Spontaneous Activated B-Cell like Diffuse Large B-Cell Lymphoma

(2014) Georges Habineza Ndikuyeze et al.   PLoS One

NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy

(2014) Joe N Kornegay et al.   Skeletal Muscle

Mutation of Nonessential Cysteines Shows That the NF-κB Essential Modulator Forms a Constitutive Noncovalent Dimer That Binds IκB Kinase-β with High Affinity

(2013) Shaun M. Cote et al.   BIOCHEMISTRY

Comprehensive Experimental and Computational Analysis of Binding Energy Hot Spots at the NF-κB Essential Modulator/IKKβ Protein–Protein Interface

(2013) Mary S. Golden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology

(2011) Daniel P. Reay et al.   NEUROBIOLOGY OF DISEASE

Development of Small-Molecule PUMA Inhibitors for Mitigating Radiation-Induced Cell Death

(2010) Gabriela Mustata et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel Insights into the Cellular Mechanisms of the Anti-inflammatory Effects of NF-κB Essential Modulator Binding Domain Peptides

(2010) Eric T. Baima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

(2008) S. A. Villalta et al.   HUMAN MOLECULAR GENETICS

Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

(2008) Mia Rushe et al.   STRUCTURE