Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way

The PIDDosome activates p53 in response to supernumerary centrosomes

(2017) Luca L. Fava et al.   GENES & DEVELOPMENT

5-Flurouracil disrupts nuclear export and nuclear pore permeability in a calcium dependent manner

(2016) Kelly J. Higby et al.   APOPTOSIS

The Nuclear Pore Complex as a Flexible and Dynamic Gate

(2016) Kevin E. Knockenhauer et al.   CELL

Simple rules for passive diffusion through the nuclear pore complex

(2016) Benjamin L. Timney et al.   JOURNAL OF CELL BIOLOGY

Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

(2016) Olivier Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A bead-based cleavage method for large-scale identification of protease substrates

(2016) Chunli Wang et al.   Scientific Reports

Role of the nucleus in apoptosis: signaling and execution

(2015) Evgeniia A. Prokhorova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Nuclear Proteome of a Vertebrate

(2015) Martin Wühr et al.   CURRENT BIOLOGY

The nuclear pore complex - structure and function at a glance

(2015) G. Kabachinski et al.   JOURNAL OF CELL SCIENCE

Sox11 Reduces Caspase-6 Cleavage and Activity

(2015) Elaine Waldron-Roby et al.   PLoS One

Targeting nucleocytoplasmic transport in cancer therapy

(2015) Richard Hill et al.   Oncotarget

Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP

(2014) Masanobu Tsubaki et al.   BIOMEDICINE & PHARMACOTHERAPY

A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway

(2014) Min Lu et al.   CELL

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Structural Mechanism of Nuclear Transport Mediated by Importin β and Flexible Amphiphilic Proteins

(2014) Shige H. Yoshimura et al.   STRUCTURE

Non-apoptotic functions of caspase-7 during osteogenesis

(2014) E Svandova et al.   Cell Death & Disease

Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope

(2013) Jianchun Wu et al.   CELL RESEARCH

l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice

(2013) Maritza J. Romero et al.   Frontiers in Immunology

Caspase-7 in molar tooth development

(2012) E. Matalova et al.   ARCHIVES OF ORAL BIOLOGY

Phosphorylation meets nuclear import: a review

(2012) Jonathan D Nardozzi et al.   Cell Communication and Signaling

The Nup153-Nup50 Protein Interface and Its Role in Nuclear Import

(2012) Masaki Makise et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptotic DNA Fragmentation May Be a Cooperative Activity between Caspase-activated Deoxyribonuclease and the Poly(ADP-ribose) Polymerase-regulated DNAS1L3, an Endoplasmic Reticulum-localized Endonuclease That Translocates to the Nucleus during Apoptosis

(2012) Youssef Errami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Karyopherin-independent spontaneous transport of amphiphilic proteins through the nuclear pore

(2012) M. Kumeta et al.   JOURNAL OF CELL SCIENCE

The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells

(2012) Emily D. Crawford et al.   MOLECULAR & CELLULAR PROTEOMICS

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling

(2012) Kiyohiro Ando et al.   MOLECULAR CELL

The Interaction Between Importin-α and Nup153 Promotes Importin-α/β-Mediated Nuclear Import

(2012) Yutaka Ogawa et al.   TRAFFIC

Caspase Substrates and Cellular Remodeling

(2011) Emily D. Crawford et al.   Annual Review of Biochemistry

Nuclear retention of importin α coordinates cell fate through changes in gene expression

(2011) Yoshinari Yasuda et al.   EMBO JOURNAL

The C-terminal domain of Nup93 is essential for assembly of the structural backbone of nuclear pore complexes

(2011) Ruchika Sachdev et al.   MOLECULAR BIOLOGY OF THE CELL

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based specific cleavage activity

(2010) Min Luo et al.   CELL RESEARCH

Tethering Function of the Caspase Cleavage Fragment of Golgi Protein p115 Promotes Apoptosis via a p53-dependent Pathway

(2010) Poh Choo How et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-9-dependent decrease of nuclear pore channel hydrophobicity is accompanied by nuclear envelope leakiness

(2010) Armin Kramer et al.   Nanomedicine-Nanotechnology Biology and Medicine

Caspases and Kinases in a Death Grip

(2009) Manabu Kurokawa et al.   CELL

ATM Augments Nuclear Stabilization of DYRK2 by Inhibiting MDM2 in the Apoptotic Response to DNA Damage

(2009) Naoe Taira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase

(2009) D. K. Moss et al.   JOURNAL OF CELL SCIENCE

Controlling subcellular localization to alter function: Sending oncogenic Bcr–Abl to the nucleus causes apoptosis

(2009) Andrew S. Dixon et al.   JOURNAL OF CONTROLLED RELEASE

Characterization of Cytoplasmic Caspase-2 Activation by Induced Proximity

(2009) Lisa Bouchier-Hayes et al.   MOLECULAR CELL

Ran out of the nucleus for apoptosis

(2009) Andrew Wilde et al.   NATURE CELL BIOLOGY

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-mediated cleavage of importin-α increases its affinity for MCM and downregulates DNA synthesis by interrupting the binding of MCM to chromatin

(2008) Byung Ju Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis

(2008) A Mazars et al.   CELL DEATH AND DIFFERENTIATION

HtrA2 enhances the apoptotic functions of p73 on bax

(2008) M Marabese et al.   CELL DEATH AND DIFFERENTIATION

Dissection of the molecular mechanisms that control the nuclear accumulation of transport factors importin-α and CAS in stressed cells

(2008) M. Kodiha et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

(2008) Simon C. Warby et al.   HUMAN MOLECULAR GENETICS

Generation and Characterization of a Monoclonal Antibody Against NPI-1 Subfamily of Importin α

(2008) Taro Tachibana et al.   HYBRIDOMA

Apoptotic histone modification inhibits nuclear transport by regulating RCC1

(2008) Chi-Hang Wong et al.   NATURE CELL BIOLOGY

Induction of Apoptosis in Murine Neuroblastoma by Systemic Delivery of Transferrin-Shielded siRNA Polyplexes for Downregulation of Ran

(2008) Nicole Tietze et al.   OLIGONUCLEOTIDES

Apoptosis leads to a degradation of vital components of active nuclear transport and a dissociation of the nuclear lamina

(2008) A. Kramer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear trafficking of pro-apoptotic kinases in response to DNA damage

(2008) Kiyotsugu Yoshida   TRENDS IN MOLECULAR MEDICINE