Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway

Effectiveness and safety of bifidobacteria and berberine in people with hyperglycemia: study protocol for a randomized controlled trial

(2018) Jie Ming et al.   Trials

The Preconditioning of Berberine Suppresses Hydrogen Peroxide-Induced Premature Senescence via Regulation of Sirtuin 1

(2017) Xiaofei Zhu et al.   Oxidative Medicine and Cellular Longevity

Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity

(2017) Jie-Ning Zhu et al.   Scientific Reports

Doxorubicin-induced oxidative stress: The protective effect of nicorandil on HL-1 cardiomyocytes

(2017) Mari C. Asensio-López et al.   PLoS One

New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases

(2016) Fabio Di Lisa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial involvement in myocyte death and heart failure

(2016) Michael J. Goldenthal   HEART FAILURE REVIEWS

SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy

(2016) Donato Cappetta et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity

(2016) Shreesh Ojha et al.   Oxidative Medicine and Cellular Longevity

The effect of berberine on insulin resistance in women with polycystic ovary syndrome: detailed statistical analysis plan (SAP) for a multicenter randomized controlled trial

(2016) Ying Zhang et al.   Trials

Rhizoma Coptidis: A Potential Cardiovascular Protective Agent

(2016) Hui-Li Tan et al.   Frontiers in Pharmacology

p66Shc signaling is involved in stress responses elicited by anthracycline treatment of rat cardiomyoblasts

(2015) Susana F. Sampaio et al.   ARCHIVES OF TOXICOLOGY

SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats

(2015) Mingge Ding et al.   Cardiovascular Diabetology

SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways

(2015) Yang Ruan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols, and Berberine) in Patients with Low-Moderate Risk Hypercholesterolemia: A Double-Blind, Placebo-Controlled Study

(2015) Stefano Gonnelli et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Sulforaphane protects the heart from doxorubicin-induced toxicity

(2015) Preeti Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cyclovirobuxine D Attenuates Doxorubicin-Induced Cardiomyopathy by Suppression of Oxidative Damage and Mitochondrial Biogenesis Impairment

(2015) Qian Guo et al.   Oxidative Medicine and Cellular Longevity

Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1

(2015) Zhuangzhi Meng et al.   Experimental and Therapeutic Medicine

Synergistic interaction between lipid-loading and doxorubicin exposure in Huh7 hepatoma cells results in enhanced cytotoxicity and cellular oxidative stress: implications for acute and chronic care of obese cancer patients

(2015) S. AlGhamdi et al.   Toxicology Research

Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: Role of autophagy

(2014) Yao-Jun Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Sirtuin 1-Mediated Inhibition of p66shc Expression Alleviates Liver Ischemia/Reperfusion Injury

(2014) Hu Yan et al.   CRITICAL CARE MEDICINE

Protective Effects of Berberine on Isoproterenol-Induced Acute Myocardial Ischemia in Rats through Regulating HMGB1-TLR4 Axis

(2014) Tianzhu Zhang et al.   Evidence-based Complementary and Alternative Medicine

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition

(2014) M Bonora et al.   ONCOGENE

Novel Role of Silent Information Regulator 1 in Myocardial Ischemia

(2013) Yang Yang et al.   CIRCULATION

Quercetin augments the protective effect of losartan against chronic doxorubicin cardiotoxicity in rats

(2013) Asmaa I. Matouk et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo

(2013) Henry J. Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

(2013) Filipa S. Carvalho et al.   MEDICINAL RESEARCH REVIEWS

New role of silent information regulator 1 in cerebral ischemia

(2013) Yang Yang et al.   NEUROBIOLOGY OF AGING

The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration

(2013) Costanza Savino et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress in Cardiovascular Diseases and Obesity: Role of p66Shc and Protein Kinase C

(2013) Elena De Marchi et al.   Oxidative Medicine and Cellular Longevity

Cardioprotective effect of Vedic Guard against doxorubicin-induced cardiotoxicity in rats: A biochemical, electrocardiographic, and histopathological study

(2013) BasavarajC Koti et al.   Pharmacognosy Magazine

Berberine in combination with doxorubicin suppresses growth of murine melanoma B16F10 cells in culture and xenograft

(2013) Anil Mittal et al.   PHYTOMEDICINE

Cross-talk between SIRT1 and p66Shc in vascular diseases

(2013) Hou-Zao Chen et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Oxidative Stress, Redox Signaling, and Metal Chelation in Anthracycline Cardiotoxicity and Pharmacological Cardioprotection

(2012) Martin Štěrba et al.   ANTIOXIDANTS & REDOX SIGNALING

Berberine: New perspectives for old remedies

(2012) Micol Tillhon et al.   BIOCHEMICAL PHARMACOLOGY

Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling

(2012) Baicheng He   INTERNATIONAL JOURNAL OF ONCOLOGY

Hepatoprotection of Berberine Against Hydrogen Peroxide-induced Apoptosis by Upregulation of Sirtuin 1

(2012) Xiaofei Zhu et al.   PHYTOTHERAPY RESEARCH

The H1–H2 domain of the α1 isoform of Na+–K+–ATPase is involved in ouabain toxicity in rat ventricular myocytes

(2012) Chen Xiong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Berberine sensitizes mutliple human cancer cells to the anticancer effects of doxorubicin in vitro

(2012) NANNAN TONG et al.   Oncology Letters

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

(2011) Ana P. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

(2011) C. Zhang et al.   CARDIOVASCULAR RESEARCH

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

(2011) Shuang Zhou et al.   CIRCULATION RESEARCH

Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway

(2010) Jeevitha B. Patil et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Final Common Molecular Pathways of Aging and Cardiovascular Disease

(2007) Francesco Cosentino et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY