Epigallocatechin-3-Gallate (EGCG) Promotes Autophagy-Dependent Survival via Influencing the Balance of mTOR-AMPK Pathways upon Endoplasmic Reticulum Stress

Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans

(2018) Li-Gui Xiong et al.   Redox Biology

The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Inhibits Obesity, Metabolic Syndrome, and Fatty Liver Disease in High-Fat–Fed Mice

(2018) Mousumi Bose et al.   JOURNAL OF NUTRITION

Insights on the involvement of (–)-epigallocatechin gallate in ER stress-mediated apoptosis in age-related macular degeneration

(2016) Bose Karthikeyan et al.   APOPTOSIS

Epigallocatechin gallate sensitizes cisplatin-resistant oral cancer CAR cell apoptosis and autophagy through stimulating AKT/STAT3 pathway and suppressing multidrug resistance 1 signaling

(2016) Chien-Han Yuan et al.   ENVIRONMENTAL TOXICOLOGY

“Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes

(2016) Francesco Prattichizzo et al.   Oxidative Medicine and Cellular Longevity

GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy

(2016) Marianna Holczer et al.   PLoS One

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

(2016) Dohyun Park et al.   Scientific Reports

Epigallocatechin-3-gallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication

(2015) L Zhong et al.   Cell Death & Disease

EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells

(2015) Ju-Hee Lee et al.   Oncotarget

A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress

(2015) Marianna Holczer et al.   Biomed Research International

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Effect of Antioxidants Supplementation on Aging and Longevity

(2014) Izabela Sadowska-Bartosz et al.   Biomed Research International

mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress - An experimental and modeling study

(2014) Orsolya Kapuy et al.   FEBS Open Bio

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

(2014) Hae-Suk Kim et al.   Redox Biology

The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age-associated inflammation and oxidative stress in healthy rats

(2013) Yucun Niu et al.   AGING CELL

Inhibition of microsomal cortisol production by (-)-epigallocatechin-3-gallate through a redox shift in the endoplasmic reticulum-A potential new target for treating obesity-related diseases

(2013) Péter Szelényi et al.   BIOFACTORS

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

(2013) Hae-Suk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosis

(2012) Orsolya Kapuy et al.   Molecular BioSystems

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor

(2011) Glenn S. Van Aller et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy: for better or for worse

(2011) Ellen Wirawan et al.   CELL RESEARCH

GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway

(2011) Alise Hyrskyluoto et al.   EXPERIMENTAL CELL RESEARCH

mTOR Signaling, Function, Novel Inhibitors, and Therapeutic Targets

(2011) R. Watanabe et al.   JOURNAL OF NUCLEAR MEDICINE

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Tea flavan-3-ols as modulating factors in endoplasmic reticulum function

(2011) Katalin Révész et al.   NUTRITION RESEARCH

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Regulation of Autophagy in the Heart: “You Only Live Twice”

(2010) Yaron Aviv et al.   ANTIOXIDANTS & REDOX SIGNALING

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells

(2009) Chi-Hung Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress

(2008) Longze Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE