Tetramethylpyrazine Attenuates the Endotheliotoxicity and the Mitochondrial Dysfunction by Doxorubicin via 14-3-3γ/Bcl-2

Quercetin protects cardiomyocytes against doxorubicin-induced toxicity by suppressing oxidative stress and improving mitochondrial function via 14-3-3γ

(2019) Xuanying Chen et al.   TOXICOLOGY MECHANISMS AND METHODS

Mesenchymal Stem Cell Therapy for Doxorubicin-Induced Cardiomyopathy: Potential Mechanisms, Governing Factors, and Implications of the Heart Stem Cell Debate

(2019) Abdelrahman Ibrahim Abushouk et al.   Frontiers in Pharmacology

Nutritional preconditioning induced by astragaloside Ⅳ on isolated hearts and cardiomyocytes against myocardial ischemia injury via improving Bcl-2-mediated mitochondrial function

(2019) Yong Luo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Crosstalk between Connexin 32 and mitochondrial apoptotic signaling pathway plays a pivotal role in renal ischemia reperfusion–induced acute kidney injury

(2018) Chaojin Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice

(2018) Dustin M. Lee et al.   Cardiovascular Diabetology

Molecular mechanism of doxorubicin-induced cardiomyopathy – An update

(2018) Kaviyarasi Renu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tetramethylpyrazine attenuates lipopolysaccharide-induced cardiomyocyte injury via improving mitochondrial function mediated by 14-3-3γ

(2018) Bowei Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways

(2018) Fan Tang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Capsaicin prevents mitochondrial damage, protects cardiomyocytes subjected to anoxia/reoxygenation injury mediated by 14-3-3η/Bcl-2

(2018) Jiyi Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2

(2018) Junduo Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toxicity of Doxorubicin (Dox) to different experimental organ systems

(2018) Arivalagan Pugazhendhi et al.   LIFE SCIENCES

Tanshinone IIA Pretreatment Protects H9c2 Cells against Anoxia/Reoxygenation Injury: Involvement of the Translocation of Bcl-2 to Mitochondria Mediated by 14-3-3η

(2018) Zeyu Zhang et al.   Oxidative Medicine and Cellular Longevity

Doxorubicin targets multiple players: A new view of an old problem

(2018) Donato Cappetta et al.   PHARMACOLOGICAL RESEARCH

Luteoloside attenuates anoxia/reoxygenation-induced cardiomyocytes injury via mitochondrial pathway mediated by 14-3-3η protein

(2018) Zhantu Liu et al.   PHYTOTHERAPY RESEARCH

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α

(2018) Emilia Mira et al.   Nature Communications

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

(2018) Shengquan Hu et al.   Frontiers in Pharmacology

Salvianolic Acid B Improves Mitochondrial Function in 3T3-L1 Adipocytes Through a Pathway Involving PPARγ Coactivator-1α (PGC-1α)

(2018) Yanyun Pan et al.   Frontiers in Pharmacology

Panax ginseng Polysaccharide Protected H9c2 Cardiomyocyte From Hypoxia/Reoxygenation Injury Through Regulating Mitochondrial Metabolism and RISK Pathway

(2018) Yi-Han Zuo et al.   Frontiers in Physiology

Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ

(2018) Huan He et al.   Food & Function

A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways

(2018) Haiyun Chen et al.   Frontiers in Neuroscience

Strategies to detect mitochondrial oxidants

(2018) Alicia J. Kowaltowski   Redox Biology

Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells

(2017) Jicheng Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Tetramethylpyrazine nitrone protects retinal ganglion cells against N -methyl-d -aspartate-induced excitotoxicity

(2017) Xiaopeng Luo et al.   JOURNAL OF NEUROCHEMISTRY

Polyphenols, autophagy and doxorubicin-induced cardiotoxicity

(2017) S. Shabalala et al.   LIFE SCIENCES

Glutathione as a Redox Biomarker in Mitochondrial Disease—Implications for Therapy

(2017) et al.   Journal of Clinical Medicine

Investigating mitochondrial redox state using NADH and NADPH autofluorescence

(2016) Thomas S. Blacker et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of Bcl-2 Signal Pathway in the Protective Effects of Apigenin on Anoxia/Reoxygenation-induced Myocardium Injury

(2016) Chuanjun Chen et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Phosphorylation of Nonmuscle Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats Through a Mechanism Involving Downregulation of Dimethylarginine Dimethylaminohydrolase 2

(2016) Yan Wu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Locally and traditionally used Ligusticum species – A review of their phytochemistry, pharmacology and pharmacokinetics

(2016) Paul Owusu Donkor et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury

(2016) Wendong Huang et al.   Molecular Medicine Reports

Tetramethylpyrazine Nitrone Improves Neurobehavioral Functions and Confers Neuroprotection on Rats with Traumatic Brain Injury

(2016) Gaoxiao Zhang et al.   NEUROCHEMICAL RESEARCH

Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart

(2016) Daoxu Qu et al.   Oxidative Medicine and Cellular Longevity

Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective

(2016) Yingke Zhao et al.   Oxidative Medicine and Cellular Longevity

A Novel Agent Enhances the Chemotherapeutic Efficacy of Doxorubicin in MCF-7 Breast Cancer Cells

(2016) Liang Wang et al.   Frontiers in Pharmacology

The Reversal Effect and Its Mechanisms of Tetramethylpyrazine on Multidrug Resistance in Human Bladder Cancer

(2016) Shanshan Wang et al.   PLoS One

Detrimental effects of chemotherapeutics and other drugs on the endothelium: A call for endothelial toxicity profiling

(2015) Tomasz Wojcik et al.   Pharmacological Reports

Antiarrhythmic activity of new 2-methoxyphenylpiperazine xanthone derivatives after ischemia/reperfusion in rats

(2015) Anna Rapacz et al.   Pharmacological Reports

Mitochondrial mechanisms of endothelial dysfunction

(2015) Adam Szewczyk et al.   Pharmacological Reports

Ginsenoside Rg3 antagonizes adriamycin-induced cardiotoxicity by improving endothelial dysfunction from oxidative stress via upregulating the Nrf2-ARE pathway through the activation of akt

(2015) Xiaoying Wang et al.   PHYTOMEDICINE

14-3-3γ protein attenuates lipopolysaccharide-induced cardiomyocytes injury through the Bcl-2 family/mitochondria pathway

(2014) Dan Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Protein Kinase C Epsilon Regulates Mitochondrial Pools of Nampt and NAD Following Resveratrol and Ischemic Preconditioning in the Rat Cortex

(2014) Kahlilia C Morris-Blanco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Prevention of Anthracycline-Induced Cardiotoxicity

(2014) Pimprapa Vejpongsa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondria, endothelial cell function, and vascular diseases

(2014) Xiaoqiang Tang et al.   Frontiers in Physiology

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Synergistic protective effect of cyclosporin A and rotenone against hypoxia–reoxygenation in cardiomyocytes

(2012) Geoffrey Teixeira et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endothelial vascular toxicity from chemotherapeutic agents: Preclinical evidence and clinical implications

(2011) Aspasia Soultati et al.   CANCER TREATMENT REVIEWS

Tetramethylpyrazine reverses multidrug resistance in breast cancer cells through regulating the expression and function of P-glycoprotein

(2011) Yinxu Zhang et al.   MEDICAL ONCOLOGY

Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis

(2010) Mercedes Pozuelo-Rubio   FEBS Journal

A model of ischemia and reperfusion increases JNK activity, inhibits the association of BAD and 14-3-3, and induces apoptosis of rabbit spinal neurocytes

(2010) Jin Fan et al.   NEUROSCIENCE LETTERS

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells

(2009) Xiang   ONCOLOGY REPORTS