In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo

(2020) Juan Fernández-García et al.   TRENDS IN BIOCHEMICAL SCIENCES

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

(2020) Bryan Ngo et al.   Cancer Discovery

How does mTOR sense glucose starvation? AMPK is the usual suspect

(2020) Gabriel Leprivier et al.   Cell Death Discovery

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

(2019) Ilaria Elia et al.   NATURE

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

(2019) Mark R. Sullivan et al.   Cell Metabolism

Nutrient regulation of mTORC1 at a glance

(2019) Kendall J. Condon et al.   JOURNAL OF CELL SCIENCE

Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization

(2018) Tanya Schild et al.   CANCER CELL

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

(2018) Saar Vandekeere et al.   Cell Metabolism

Metabolic Hallmarks of Metastasis Formation

(2018) Ilaria Elia et al.   TRENDS IN CELL BIOLOGY

Epithelial cell adhesion molecule overexpression regulates epithelial-mesenchymal transition, stemness and metastasis of nasopharyngeal carcinoma cells via the PTEN/AKT/mTOR pathway

(2018) Meng-He Wang et al.   Cell Death & Disease

Phospholipase D-Dependent mTORC1 Activation by Glutamine

(2018) Elyssa Bernfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation

(2018) Roberto Vendramin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of mitochondrial metabolism in situ : Combining stable isotope labeling with selective permeabilization

(2017) Yannic Nonnenmacher et al.   METABOLIC ENGINEERING

Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors

(2017) Doriane Lorendeau et al.   METABOLIC ENGINEERING

Toil enables reproducible, open source, big biomedical data analyses

(2017) John Vivian et al.   NATURE BIOTECHNOLOGY

Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate

(2017) Rob C Oslund et al.   Nature Chemical Biology

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

(2016) D. Samanta et al.   CANCER RESEARCH

Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods

(2016) Masayuki Nagahashi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo

(2016) Hong Yang et al.   Oncotarget

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

(2016) Stefan Christen et al.   Cell Reports

Metabolic control of signalling pathways and metabolic auto-regulation

(2015) Doriane Lorendeau et al.   BIOLOGY OF THE CELL

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

The expanding role of mTOR in cancer cell growth and proliferation

(2015) Marie Cargnello et al.   MUTAGENESIS

Signal Transduction in Cancer

(2015) R. Sever et al.   Cold Spring Harbor Perspectives in Medicine

Site-specific metabolic phenotypes in metastatic breast cancer

(2014) Hye Min Kim et al.   Journal of Translational Medicine

MicroRNA-193a-3p and -5p suppress the metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway

(2014) T Yu et al.   ONCOGENE

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

(2012) R V Durán et al.   ONCOGENE

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

(2012) J. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis

(2010) Sirkku Pollari et al.   BREAST CANCER RESEARCH AND TREATMENT

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis

(2007) Jamey D. Young et al.   BIOTECHNOLOGY AND BIOENGINEERING