Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation

Human marginal zone B cell development from early T2 progenitors

(2021) Thomas J. Tull et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

(2021) Yao He et al.   Cell Metabolism

Gut-derived acetate promotes B10 cells with antiinflammatory effects

(2021) C.I. Daïen et al.   JCI Insight

Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome

(2021) Alexandra J. Roth-Schulze et al.   Microbiome

Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production

(2020) Edward C. Deehan et al.   Cell Host & Microbe

Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: a randomised controlled trial

(2020) Pieter F. de Groot et al.   DIABETOLOGIA

Effect of fructans, prebiotics and fibres on the human gut microbiome assessed by 16S rRNA-based approaches: a review

(2020) K.S. Swanson et al.   Beneficial Microbes

Differential Expression of IgM and IgD Discriminates Two Subpopulations of Human Circulating IgM+IgD+CD27+ B Cells That Differ Phenotypically, Functionally, and Genetically

(2020) Diana Bautista et al.   Frontiers in Immunology

Gut microbial metabolites alter IgA immunity in type 1 diabetes

(2020) Juan Huang et al.   JCI Insight

Gut microbiota modulation with long-chain corn bran arabinoxylan in adults with overweight and obesity is linked to an individualized temporal increase in fecal propionate

(2020) Nguyen K. Nguyen et al.   Microbiome

Exhausted-like CD8 T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects

(2020) Kirsten E. Diggins et al.   JCI Insight

Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

(2019) Kai Wang et al.   Cell Reports

Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males

(2019) Maartje C. P. Cleophas et al.   Scientific Reports

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

(2019) Maik Luu et al.   Nature Communications

Metagenomic analysis of microbe-mediated vitamin metabolism in the human gut microbiome

(2019) Promi Das et al.   BMC GENOMICS

Circulating levels of butyrate are inversely related to portal hypertension, endotoxemia, and systemic inflammation in patients with cirrhosis

(2019) Oriol Juanola et al.   FASEB JOURNAL

Effect of prebiotic on microbiota, intestinal permeability and glycemic control in children with type 1 diabetes

(2019) Josephine Ho et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effects of the resistant starch on glucose, insulin, insulin resistance, and lipid parameters in overweight or obese adults: a systematic review and meta-analysis

(2019) Yong Wang et al.   Nutrition & Diabetes

Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health

(2019) Kaitlyn Oliphant et al.   Microbiome

Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond

(2019) Wegh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An NADH-Dependent Reductase from Eubacterium ramulus Catalyzes the Stereospecific Heteroring Cleavage of Flavanones and Flavanonols

(2019) Annett Braune et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metagenomic profiling of the pro-inflammatory gut microbiota in ankylosing spondylitis

(2019) Chen Zhou et al.   JOURNAL OF AUTOIMMUNITY

Postprandial glucose and insulin response to a high-fiber muffin top containing resistant starch type 4 in healthy adults: a double-blind, randomized, controlled trial

(2018) Maria L. Stewart et al.   NUTRITION

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

(2018) Liping Zhao et al.   SCIENCE

Intestinal Metaproteomics Reveals Host-Microbiota Interactions in Subjects at Risk for Type 1 Diabetes

(2018) Patrick G. Gavin et al.   DIABETES CARE

Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes

(2018) Susanne M. Cabrera et al.   DIABETOLOGIA

Early-life exposure to gut microbiota from disease protected mice does not impact disease outcome in type 1 diabetes susceptible NOD mice

(2018) Jane A. Mullaney et al.   IMMUNOLOGY AND CELL BIOLOGY

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

(2018) Tommi Vatanen et al.   NATURE

Temporal development of the gut microbiome in early childhood from the TEDDY study

(2018) Christopher J. Stewart et al.   NATURE

Species-level functional profiling of metagenomes and metatranscriptomes

(2018) Eric A. Franzosa et al.   NATURE METHODS

Proinsulin C-peptide is an autoantigen in people with type 1 diabetes

(2018) Michelle So et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homeostatic Immunity and the Microbiota

(2017) Yasmine Belkaid et al.   IMMUNITY

Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study

(2017) Pieter F. de Groot et al.   PLoS One

Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC

(2016) Wenpeng Dong et al.   JOURNAL OF ENDOCRINOLOGY

Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: a randomised clinical trial

(2015) Richard K. Le Leu et al.   BRITISH JOURNAL OF NUTRITION

Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease

(2015) Holly A. Bolton et al.   JOURNAL OF CLINICAL INVESTIGATION

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Increased Blood Levels of Growth Factors, Proinflammatory Cytokines, and Th17 Cytokines in Patients with Newly Diagnosed Type 1 Diabetes

(2015) Kristi Alnek et al.   PLoS One

Fatty acid metabolism in the regulation of T cell function

(2015) Matthias Lochner et al.   TRENDS IN IMMUNOLOGY

Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community

(2015) Hirosuke Sugahara et al.   Scientific Reports

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Aberrant gut microbiota composition at the onset of type 1 diabetes in young children

(2014) Marcus C. de Goffau et al.   DIABETOLOGIA

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses

(2014) Nicole Joller et al.   IMMUNITY

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Normalization of RNA-seq data using factor analysis of control genes or samples

(2014) Davide Risso et al.   NATURE BIOTECHNOLOGY

Regulatory B cells are induced by gut microbiota–driven interleukin-1β and interleukin-6 production

(2014) Elizabeth C Rosser et al.   NATURE MEDICINE

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

The Systemic Immune Network in Recent Onset Type 1 Diabetes: Central Role of Interleukin-1 Receptor Antagonist (DIATOR Trial)

(2013) Hubert Kolb et al.   PLoS One

Resistant Starch from High-Amylose Maize Increases Insulin Sensitivity in Overweight and Obese Men

(2012) Kevin C. Maki et al.   JOURNAL OF NUTRITION

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Metagenomic microbial community profiling using unique clade-specific marker genes

(2012) Nicola Segata et al.   NATURE METHODS

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Butyrate esterified to starch is released in the human gastrointestinal tract

(2011) Julie M Clarke et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition

(2010) M. Kverka et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY