SIRT1 Promotes M2 Microglia Polarization via Reducing ROS-Mediated NLRP3 Inflammasome Signaling After Subarachnoid Hemorrhage

Sirt1 activator SRT2104 protects against oxygen-glucose deprivation/reoxygenation-induced injury via regulating microglia polarization by modulating Sirt1/NF-κB pathway

(2021) Chuan-Yi Fu et al.   BRAIN RESEARCH

Melatonin Ameliorates Hemorrhagic Transformation via Suppression of ROS-Induced NLRP3 Activation after Cerebral Ischemia in Hyperglycemic Rats

(2021) Anwen Shao et al.   Oxidative Medicine and Cellular Longevity

Cerebroprotection by dioscin after experimental subarachnoid hemorrhage via inhibiting NLRP3 inflammasome through SIRT1‐dependent pathway

(2021) Xiang‐Sheng Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway

(2021) Bei Ren et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage

(2021) William S. Dodd et al.   Journal of Neuroinflammation

Saffron extract attenuates neuroinflammation in rmTBI mouse model by suppressing NLRP3 inflammasome activation via SIRT1

(2021) Mariam J. Shaheen et al.   PLoS One

Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells

(2021) Chinmaya Panda et al.   Cells

Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2/HO-1/NLRP3 signaling pathway

(2021) Weiwei Tao et al.   PHYTOMEDICINE

Transforming Growth Factor Beta-Activated Kinase 1–Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke

(2020) Rongrong Wang et al.   STROKE

Microglia-Derived NLRP3 Activation Mediates the Pressor Effect of Prorenin in the Rostral Ventrolateral Medulla of Stress-Induced Hypertensive Rats

(2020) Li Hu et al.   Neuroscience Bulletin

Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-κB signaling pathway

(2020) Yong Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity

(2020) Jasminka Giacometti et al.   Oxidative Medicine and Cellular Longevity

MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH

(2020) Weixiang Chen et al.   PHARMACOLOGICAL RESEARCH

Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway

(2020) Xiang-Hua Zhang et al.   Frontiers in Pharmacology

SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion

(2020) Ying Han et al.   Redox Biology

Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway

(2020) Xiang-Sheng Zhang et al.   MOLECULAR NEUROBIOLOGY

Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation

(2020) Hong Feng et al.   Oxidative Medicine and Cellular Longevity

Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice

(2020) Xiang‐Sheng Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

20‐HETE synthesis inhibition attenuates traumatic brain injury–induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC‐1α pathway: A translational study

(2020) Wenxing Cui et al.   CELL PROLIFERATION

SIRT1 mediates hypoxic preconditioning induced attenuation of neurovascular dysfunction following subarachnoid hemorrhage

(2020) Ananth K. Vellimana et al.   EXPERIMENTAL NEUROLOGY

MFG-E8 attenuates inflammation in subarachnoid hemorrhage by driving microglial M2 polarization

(2020) Yong-Yue Gao et al.   EXPERIMENTAL NEUROLOGY

Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators

(2019) Di Shao et al.   Redox Biology

DHEA Attenuates Microglial Activation via Induction of JMJD3 in Experimental Subarachnoid Haemorrhage

(2019) Tao Tao et al.   Journal of Neuroinflammation

The Dynamics of Microglial Polarization Reveal the Resident Neuroinflammatory Responses After Subarachnoid Hemorrhage

(2019) Zhiyuan Vera Zheng et al.   Translational Stroke Research

SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice

(2019) Chun-Mei Duan et al.   BEHAVIOURAL BRAIN RESEARCH

Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage

(2018) Yue Lu et al.   Journal of Neuroinflammation

OUP accepted manuscript

(2018)   NEUROSURGERY

Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway

(2018) Xiangsheng Zhang et al.   FASEB JOURNAL

Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway

(2018) Fu-yi Liu et al.   Journal of Neuroinflammation

An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury

(2017) Haihong Chen et al.   JOURNAL OF NEUROSCIENCE

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide

(2017) Wei Zhu et al.   NEUROSCIENCE

Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat

(2017) Keren Zhou et al.   STROKE

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

(2016) Alok Kumar et al.   JOURNAL OF NEUROTRAUMA

Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage

(2016) Zhen Zhang et al.   MOLECULAR NEUROBIOLOGY

Melatonin Attenuates Early Brain Injury via the Melatonin Receptor/Sirt1/NF-κB Signaling Pathway Following Subarachnoid Hemorrhage in Mice

(2016) Lei Zhao et al.   MOLECULAR NEUROBIOLOGY

Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats

(2016) Xiang-Sheng Zhang et al.   Cell Death & Disease

Promotion of behavior and neuronal function by reactive oxygen species in C. elegans

(2016) Guang Li et al.   Nature Communications

Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury

(2015) Xiaoning Han et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1 

(2015) S.-H. Cho et al.   JOURNAL OF NEUROSCIENCE

Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling

(2015) Lei Zhao et al.   JOURNAL OF PINEAL RESEARCH

SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage

(2014) Xiao-Ming Zhou et al.   JOURNAL OF NEUROSCIENCE RESEARCH

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

Long-Term Functional Consequences and Ongoing Cerebral Inflammation after Subarachnoid Hemorrhage in the Rat

(2014) Elke Kooijman et al.   PLoS One

Neurological and Histological Consequences Induced by In Vivo Cerebral Oxidative Stress: Evidence for Beneficial Effects of SRT1720, a Sirtuin 1 Activator, and Sirtuin 1-Mediated Neuroprotective Effects of Poly(ADP-ribose) Polymerase Inhibition

(2014) Cindy Gueguen et al.   PLoS One

Silent Information Regulator 2 Homolog 1 Counters Cerebral Hypoperfusion Injury by Deacetylating Endothelial Nitric Oxide Synthase

(2014) Yorito Hattori et al.   STROKE

Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage

(2013) M. Hernandez-Jimenez et al.   STROKE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model

(2007) Takashi Sugawara et al.   JOURNAL OF NEUROSCIENCE METHODS