Sirt1 activator SRT2104 protects against oxygen-glucose deprivation/reoxygenation-induced injury via regulating microglia polarization by modulating Sirt1/NF-κB pathway

Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury

(2020) Brooke Bonsack et al.   CNS Neuroscience & Therapeutics

Axonal protection by a small molecule SIRT1 activator, SRT2104, with alteration of autophagy in TNF-induced optic nerve degeneration

(2020) Yasushi Kitaoka et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

(2019) An-Qi Chen et al.   Cell Death & Disease

SRT2104 attenuates diabetes-induced aortic endothelial dysfunction via inhibition of P53

(2018) Hao Wu et al.   JOURNAL OF ENDOCRINOLOGY

MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death

(2018) Dan Jiao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

L-3-n-Butylphthalide reduces ischemic stroke injury and increases M2 microglial polarization

(2018) Fangfang Li et al.   METABOLIC BRAIN DISEASE

The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies

(2018) Jun-Fang Zhang et al.   Frontiers in Neuroscience

Neuroprotective mechanisms and translational potential of therapeutic hypothermia in the treatment of ischemic stroke

(2017) ShanPing Yu et al.   Neural Regeneration Research

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

(2017) Zongjian Liu et al.   Frontiers in Aging Neuroscience

Ginkgolide B Protects Against Ischemic Stroke Via Modulating Microglia Polarization in Mice

(2016) Zhao-Ma Shu et al.   CNS Neuroscience & Therapeutics

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

Lowering C-reactive protein with statins after an ischemic stroke avoids mortality and readmissions. A prospective cohort study

(2015) José Carlos Arévalo-Lorido et al.   ANNALS OF MEDICINE

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

(2015) James G. Krueger et al.   PLoS One

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

(2014) Mali Jiang et al.   Annals of Clinical and Translational Neurology

Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

(2012) Ethan Hoffmann et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Mammalian Sirt1: insights on its biological functions

(2011) Shahedur Rahman et al.   Cell Communication and Signaling

Stroke Epidemiology: Advancing Our Understanding of Disease Mechanism and Therapy

(2011) Bruce Ovbiagele et al.   Neurotherapeutics

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Caloric restriction, SIRT1 and longevity

(2009) Carles Cantó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN