Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2/HO-1/NLRP3 signaling pathway

Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties

(2021) Iris Usach et al.   Pharmaceutics

Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice

(2021) Menglin Zheng et al.   BRAIN RESEARCH BULLETIN

Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression

(2020) Viviane de Sousa Tomaz et al.   JOURNAL OF AFFECTIVE DISORDERS

Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

(2020) Hetao Bian et al.   Journal of Neuroinflammation

Targeting xanthine oxidase by natural products as a therapeutic approach for mental disorders

(2020) Miquel Martorell et al.   CURRENT PHARMACEUTICAL DESIGN

Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer’s Disease

(2020) Yan-Fang Xian et al.   Oxidative Medicine and Cellular Longevity

Celastrol alleviates metabolic disturbance in high‐fat diet‐induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation

(2020) Xueping Yang et al.   PHYTOTHERAPY RESEARCH

Antidepressant and Anti-Neuroinflammatory Effects of Bangpungtongsung-San

(2020) Bo-Kyung Park et al.   Frontiers in Pharmacology

Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers

(2020) Guodong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The role of CCR5 in the protective effect of Esculin on lipopolysaccharide-induced depressive symptom in mice

(2020) Tong Chen et al.   JOURNAL OF AFFECTIVE DISORDERS

Fingolimod suppressed the chronic unpredictable mild stress-induced depressive-like behaviors via affecting microglial and NLRP3 inflammasome activation

(2020) Yuanxin Guo et al.   LIFE SCIENCES

Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments

(2020) Peipei Cao et al.   Journal of Inflammation Research

Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

(2019) Ana Rita Vaz et al.   Frontiers in Cellular Neuroscience

Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine

(2019) Wenqing Gong et al.   JOURNAL OF AFFECTIVE DISORDERS

The Intra-nuclear SphK2-S1P Axis Facilitates M1-to-M2 Shift of Microglia via Suppressing HDAC1-Mediated KLF4 Deacetylation

(2019) Juan Ji et al.   Frontiers in Immunology

Keap1/Nrf2/HO-1 signaling pathway contributes to p-chlorodiphenyl diselenide antidepressant-like action in diabetic mice

(2019) Vanessa A. Zborowski et al.   PSYCHOPHARMACOLOGY

Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice

(2018) Jie Cheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cyclic AMP Pathway Suppress Autoimmune Neuroinflammation by Inhibiting Functions of Encephalitogenic CD4 T Cells and Enhancing M2 Macrophage Polarization at the Site of Inflammation

(2018) Tatyana Veremeyko et al.   Frontiers in Immunology

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

(2018) Abhishek Ranaware et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-κB and IDO-1

(2018) Priyansha Choubey et al.   PSYCHOPHARMACOLOGY

Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms

(2017) H Engler et al.   MOLECULAR PSYCHIATRY

Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson’s disease using in vivo 18F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging

(2017) Chi-Chang Weng et al.   PLoS One

Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling

(2017) Young-Won Kwon et al.   Frontiers in Cellular Neuroscience

The protective mechanism of docosahexaenoic acid in mouse model of Parkinson: The role of heme oxygenase

(2016) Ayse Ozkan et al.   NEUROCHEMISTRY INTERNATIONAL

Magnolol Enhances Hippocampal Neurogenesis and Exerts Antidepressant-Like Effects in Olfactory Bulbectomized Mice

(2016) Nobuaki Matsui et al.   PHYTOTHERAPY RESEARCH

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression

(2013) Lu-Fan Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interleukin-1β orchestrates underlying inflammatory responses in microglia via Krüppel-like factor 4

(2013) Deepak K. Kaushik et al.   JOURNAL OF NEUROCHEMISTRY

Antidepressant-like Effect of Magnolol on BDNF Up-regulation and Serotonergic System Activity in Unpredictable Chronic Mild Stress Treated Rats

(2012) Lu-Fan Li et al.   PHYTOTHERAPY RESEARCH

Therapeutic applications of compounds in the Magnolia family

(2011) Young-Jung Lee et al.   PHARMACOLOGY & THERAPEUTICS