Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway

Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders

(2020) Wei-Jia Kong et al.   PHARMACOLOGY & THERAPEUTICS

Berberine-mediated up-regulation of surfactant protein D facilitates cartilage repair by modulating immune responses via the inhibition of TLR4/NF-ĸB signaling

(2020) Yan Zhou et al.   PHARMACOLOGICAL RESEARCH

Anticancer effect of berberine based on experimental animal models of various cancers: a systematic review and meta-analysis

(2019) Jianhao Xu et al.   BMC CANCER

Protection of the myocardium against ischemia/reperfusion injury by punicalagin through an SIRT1-NRF-2-HO-1-dependent mechanism

(2019) Li-Ming Yu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid‐induced biochemical alteration in mice

(2019) Peng Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Berberine enhances survival and axonal regeneration of motoneurons following spinal root avulsion and re-implantation in rats

(2019) Xie Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

DHEA Attenuates Microglial Activation via Induction of JMJD3 in Experimental Subarachnoid Haemorrhage

(2019) Tao Tao et al.   Journal of Neuroinflammation

Berberine protects against ischemia-reperfusion injury: A review of evidence from animal models and clinical studies

(2019) Dai-Qiang Liu et al.   PHARMACOLOGICAL RESEARCH

Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal Subarachnoid Hemorrhage (aSAH)

(2018) Shafqat Chaudhry et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage

(2018) Yue Lu et al.   Journal of Neuroinflammation

Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury

(2018) Xiangrong Chen et al.   Journal of Neuroinflammation

Selective Toll-Like Receptor 4 Antagonists Prevent Acute Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice

(2018) Takeshi Okada et al.   MOLECULAR NEUROBIOLOGY

Recombinant neuroglobin ameliorates early brain injury after subarachnoid hemorrhage via inhibiting the activation of mitochondria apoptotic pathway

(2018) Fuxiang Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy

(2018) Veera Ganesh Yerra et al.   NEUROPHARMACOLOGY

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

(2018) Ean-Jeong Seo et al.   PHARMACOLOGICAL RESEARCH

Berberine attenuates ischemia–reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation

(2018) Jun-rong Zhu et al.   ACTA PHARMACOLOGICA SINICA

Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway

(2018) Xiangsheng Zhang et al.   FASEB JOURNAL

Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood–brain barrier integrity

(2018) Tao Li et al.   FASEB JOURNAL

Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway

(2018) Fu-yi Liu et al.   Journal of Neuroinflammation

Mdivi-1 ameliorates early brain injury after subarachnoid hemorrhage via the suppression of inflammation-related blood–brain barrier disruption and endoplasmic reticulum stress-based apoptosis

(2017) Lin-feng Fan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats

(2017) Hidetsugu Maekawa et al.   Journal of Neuroinflammation

Spontaneous subarachnoid haemorrhage

(2017) R Loch Macdonald et al.   LANCET

Inhibition of the Receptor for Advanced Glycation End-Products (RAGE) Attenuates Neuroinflammation While Sensitizing Cortical Neurons Towards Death in Experimental Subarachnoid Hemorrhage

(2016) Hua Li et al.   MOLECULAR NEUROBIOLOGY

Effects and mechanisms of cavidine protecting mice against LPS-induced endotoxic shock

(2016) Weifeng Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats

(2016) Xiang-Sheng Zhang et al.   Cell Death & Disease

Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury

(2015) Xiaoning Han et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage

(2015) Jianru Li et al.   MOLECULAR NEUROBIOLOGY

Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia

(2015) Jung Seok Hwang et al.   Scientific Reports

Early release of high-mobility group box 1 (HMGB1) from neurons in experimental subarachnoid hemorrhage in vivo and in vitro

(2014) Qing Sun et al.   Journal of Neuroinflammation

Subarachnoid hemorrhage and the female sex: analysis of risk factors, aneurysm characteristics, and outcomes

(2014) Alhafidz Hamdan et al.   JOURNAL OF NEUROSURGERY

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

Astrocytic Toll-Like Receptor 3 Is Associated with Ischemic Preconditioning- Induced Protection against Brain Ischemia in Rodents

(2014) Lin-na Pan et al.   PLoS One

Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway

(2013) Zhong Wang et al.   JOURNAL OF PINEAL RESEARCH

Gender Influences the Initial Impact of Subarachnoid Hemorrhage: An Experimental Investigation

(2013) Victor Friedrich et al.   PLoS One

Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats

(2013) Xiang-Shan Tan et al.   PLoS One

Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

(2010) Y.-T. Liu et al.   DRUG METABOLISM AND DISPOSITION

Efficacy of berberine in patients with type 2 diabetes mellitus

(2008) Jun Yin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model

(2007) Takashi Sugawara et al.   JOURNAL OF NEUROSCIENCE METHODS