Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity

Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis

(2020) Chayanut Kaewmool et al.   JOURNAL OF NEUROIMMUNOLOGY

Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis

(2019) Jiaying Wang et al.   Frontiers in Pharmacology

Natural products as a potential modulator of microglial polarization in neurodegenerative diseases

(2019) Xin Jin et al.   PHARMACOLOGICAL RESEARCH

The Role of Sirtuins in Antioxidant and Redox Signaling

(2018) Chandra K. Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Ellagic acid protects from myelin-associated sphingolipid loss in experimental autoimmune encephalomyelitis

(2018) Rebeca Busto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging

(2018) F. Sarubbo et al.   Current Neuropharmacology

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis

(2018) Alazne Zabala et al.   EMBO Molecular Medicine

Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination

(2018) Hrvoje Jakovac et al.   NEUROSCIENCE

Sirtuins in Neuroendocrine Regulation and Neurological Diseases

(2018) Yuki Fujita et al.   Frontiers in Neuroscience

Bioactivity of Olive Oil Phenols in Neuroprotection

(2017) Cristina Angeloni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review

(2017) Vamshi K.C. Nimmagadda et al.   JOURNAL OF NEUROIMMUNOLOGY

Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission

(2017) Junghyung Park et al.   JOURNAL OF NEUROIMMUNOLOGY

The neuroprotective effects of hydro-alcoholic extract of olive (Olea europaea L.) leaf on rotenone-induced Parkinson’s disease in rat

(2017) Maryam Sarbishegi et al.   METABOLIC BRAIN DISEASE

The brain, sirtuins, and ageing

(2017) Akiko Satoh et al.   NATURE REVIEWS NEUROSCIENCE

Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats

(2017) Wenyan Sun et al.   NEUROPHARMACOLOGY

Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti-Inflammatory M2 State

(2017) Laura Dugo et al.   Oxidative Medicine and Cellular Longevity

The role of growth factors as a therapeutic approach to demyelinating disease

(2016) Yangyang Huang et al.   EXPERIMENTAL NEUROLOGY

Oxidative stress in multiple sclerosis: Central and peripheral mode of action

(2016) Kim Ohl et al.   EXPERIMENTAL NEUROLOGY

Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis

(2016) Božena Ćurko-Cofek et al.   NEUROTOXICOLOGY

New FDA-Approved Disease-Modifying Therapies for Multiple Sclerosis

(2015) Clayton English et al.   CLINICAL THERAPEUTICS

Epigenetic control of cardiovascular health by nutritional polyphenols involves multiple chromatin-modifying writer-reader-eraser proteins

(2015) Ken Declerck et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Effects of Microglia on Neurogenesis

(2015) Kaoru Sato   GLIA

Chemometric Analysis for the Evaluation of Phenolic Patterns in Olive Leaves from Six Cultivars at Different Growth Stages

(2015) Nassima Talhaoui et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage

(2015) Junli Liu et al.   JOURNAL OF NEUROCHEMISTRY

MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination

(2015) Z. Yu et al.   JOURNAL OF NEUROSCIENCE

Polyphenol-enriched cocoa protects the diabetic retina from glial reaction through the sirtuin pathway

(2015) Diego A. Duarte et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Macrophages: A double-edged sword in experimental autoimmune encephalomyelitis

(2014) Zhilong Jiang et al.   IMMUNOLOGY LETTERS

Macrophages and CNS remyelination

(2014) Veronique E. Miron et al.   JOURNAL OF NEUROCHEMISTRY

Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes

(2014) Yi Cheng et al.   JOURNAL OF NEUROIMMUNOLOGY

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

(2014) Hae-Suk Kim et al.   Redox Biology

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

Disease-specific molecular events in cortical multiple sclerosis lesions

(2013) Marie Therese Fischer et al.   BRAIN

Advances in Antioxidative Therapy of Multiple Sclerosis

(2013) E. Miller et al.   CURRENT MEDICINAL CHEMISTRY

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of SIRT1 Protein in Neurons Protects against Experimental Autoimmune Encephalomyelitis through Activation of Multiple SIRT1 Targets

(2013) V. K. Nimmagadda et al.   JOURNAL OF IMMUNOLOGY

Epigenetic effects of natural polyphenols: A focus on SIRT1-mediated mechanisms

(2013) Vincent B. Owona Ayissi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis

(2013) Tanja Grubic-Kezele et al.   NEUROIMMUNOMODULATION

Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway

(2013) Jieming Ye et al.   NEUROSCIENCE LETTERS

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation

(2013) Alessandra Di Penta et al.   PLoS One

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

(2012) Marie T. Fischer et al.   BRAIN

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

Negative regulation of inflammation by SIRT1

(2012) Jun Xie et al.   PHARMACOLOGICAL RESEARCH

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment?

(2011) Elke Verena Voß et al.   NEUROBIOLOGY OF DISEASE

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Radical changes in multiple sclerosis pathogenesis

(2010) Jack van Horssen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions

(2010) Jack van Horssen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

(2010) Joanna Mikita et al.   Multiple Sclerosis Journal

Molecular Changes in White Matter Adjacent to an Active Demyelinating Lesion in Early Multiple Sclerosis

(2009) Thomas Zeis et al.   BRAIN PATHOLOGY

Dry olive leaf extract ameliorates experimental autoimmune encephalomyelitis

(2009) Djordje Miljković et al.   CLINICAL NUTRITION

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease

(2008) B D Butts et al.   CELL DEATH AND DIFFERENTIATION

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression

(2008) J. van Horssen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Challenges for Research on Polyphenols from Foods in Alzheimer’s Disease: Bioavailability, Metabolism, and Cellular and Molecular Mechanisms

(2008) Manjeet Singh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

(2008) G. Ramadori et al.   JOURNAL OF NEUROSCIENCE

Elevated myeloperoxidase activity in white matter in multiple sclerosis

(2008) Elizabeth Gray et al.   NEUROSCIENCE LETTERS

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

(2008) S. Hisahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA