Single-Cell RNA Sequencing Reveals the Heterogeneity of Tumor-Associated Macrophage in Non-Small Cell Lung Cancer and Differences Between Sexes

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(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Metabolic reprogramming in macrophage responses

(2021) Yang Liu et al.   Biomarker Research

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

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(2021) Sheila Spada et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Conserved pan-cancer microenvironment subtypes predict response to immunotherapy

(2021) Alexander Bagaev et al.   CANCER CELL

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Sex Differences in Immunity to Viral Infections

(2021) Henning Jacobsen et al.   Frontiers in Immunology

Lung Cancer in Women

(2020) Christina R. MacRosty et al.   CLINICS IN CHEST MEDICINE

Macrophage targeting in cancer

(2020) Martha Lopez‐Yrigoyen et al.   Annals of the New York Academy of Sciences

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

(2020) Lei Zhang et al.   CELL

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer

(2020) Poonam Sarode et al.   Science Advances

Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

(2020) C. C. Bain et al.   Science Immunology

Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level

(2020) Sven Hendrik Hagen et al.   Cell Reports

Sex Difference and Smoking Effect of Lung Cancer Incidence in Asian Population

(2020) Boyoung Park et al.   Cancers

Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration

(2019) Kate Webb et al.   Frontiers in Immunology

Association of Patient Sex With Efficacy of Immune Checkpoint Inhibitors and Overall Survival in Advanced Cancers

(2019) Christopher J. D. Wallis et al.   JAMA Oncology

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Dissecting intratumoral myeloid cell plasticity by single cell RNA‐seq

(2019) Qianqian Song et al.   Cancer Medicine

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Tumor cells hijack macrophage-produced complement C1q to promote tumor growth

(2019) Lubka T. Roumenina et al.   Cancer Immunology Research

Ontogeny of Tumor-Associated Macrophages

(2019) Marie Laviron et al.   Frontiers in Immunology

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

Non–Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment

(2019) Narjust Duma et al.   MAYO CLINIC PROCEEDINGS

Sex Differences in Cancer Immunotherapy Efficacy, Biomarkers, and Therapeutic Strategy

(2019) Shixiang Wang et al.   MOLECULES

Sex‐specificity in lung cancer risk

(2019) Claudia Stapelfeld et al.   INTERNATIONAL JOURNAL OF CANCER

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Higher Lung Cancer Incidence in Young Women Than Young Men in the United States

(2018) Ahmedin Jemal et al.   NEW ENGLAND JOURNAL OF MEDICINE

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

(2018) Diana Miao et al.   NATURE GENETICS

Metal-isotope-tagged monoclonal antibodies for high-dimensional mass cytometry

(2018) Guojun Han et al.   Nature Protocols

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

(2018) John D. Klement et al.   JOURNAL OF CLINICAL INVESTIGATION

Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation

(2018) Mélanie Souyris et al.   Seminars in Immunopathology

Upregulation of PD-L1 by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma

(2017) Yan Zhang et al.   EXPERIMENTAL CELL RESEARCH

A male and female RNA marker to infer sex in forensic analysis

(2017) M. van den Berge et al.   Forensic Science International-Genetics

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Defining the biological basis of radiomic phenotypes in lung cancer

(2017) Patrick Grossmann et al.   eLife

Osteopontin splice variants are differential predictors of breast cancer treatment responses

(2016) Krzysztof Zduniak et al.   BMC CANCER

An Expression Signature as an Aid to the Histologic Classification of Non-Small Cell Lung Cancer

(2016) L. Girard et al.   CLINICAL CANCER RESEARCH

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation

(2016) Roberta Bulla et al.   Nature Communications

Repeated observation of immune gene sets enrichment in women with non-small cell lung cancer

(2016) Jhajaira M. Araujo et al.   Oncotarget

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Clinical and prognostic significance of OPN and VEGF expression in patients with non-small-cell lung cancer

(2015) Qunying Lin et al.   Cancer Epidemiology

Sex, the aging immune system, and chronic disease

(2015) Melanie R. Gubbels Bupp   CELLULAR IMMUNOLOGY

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-  Production in Women

(2015) M. Griesbeck et al.   JOURNAL OF IMMUNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-α Production of Plasmacytoid Dendritic Cells from Women

(2014) Sophie Laffont et al.   JOURNAL OF IMMUNOLOGY

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Chemokine (C–X–C motif) ligand (CXCL)10 in autoimmune diseases

(2013) Alessandro Antonelli et al.   AUTOIMMUNITY REVIEWS

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Peroxisome proliferator-activated receptor (PPAR)  and -  regulate IFN  and IL-17A production by human T cells in a sex-specific way

(2012) M. A. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

17 -Estradiol Promotes TLR4-Triggered Proinflammatory Mediator Production through Direct Estrogen Receptor   Signaling in Macrophages In Vivo

(2010) B. Calippe et al.   JOURNAL OF IMMUNOLOGY

Menopause and aging: Changes in the immune system—A review

(2010) Cátia Morgado Gameiro et al.   MATURITAS

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Immunological Basis for the Gender Differences in Murine Paracoccidioides brasiliensis Infection

(2010) Camila Figueiredo Pinzan et al.   PLoS One

Estrogens Augment Cell Surface TLR4 Expression on Murine Macrophages and Regulate Sepsis Susceptibilityin Vivo

(2009) Jennifer A. Rettew et al.   ENDOCRINOLOGY

Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis

(2009) A Hewagama et al.   GENES AND IMMUNITY

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Macrophage Functions by PPAR-α, PPAR-γ, and LXRs in Mice and Men

(2008) Elena Rigamonti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats

(2007) Michele F. Hannah et al.   BRAIN BEHAVIOR AND IMMUNITY