Article
Immunology
Pu Zhou, Diangang Chen, Bo Zhu, Wei Chen, Qichao Xie, Yali Wang, Qiulin Tan, Bibo Yuan, Xuejiao Zuo, Changlin Huang, Hongfan Zhu, Guanghui Li
Summary: The study found that the diversity of TCR repertoire and PD-L1 expression in the TME increased significantly after SBRT, with the most enriched term in gene ontology analysis being immune response genes. Although SBRT induced neo-mutation of genes in tumor cells, it did not increase the burden of tumor mutation in tissues. TME showed complex immune cell changes and infiltration, with expression of immune-regulating factors like CXCL10, CXCL16, IFNs, and IFN receptors.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Qianqian Xue, Wenbei Peng, Siyu Zhang, Xiaoshan Wei, Linlin Ye, Zihao Wang, Xuan Xiang, Pei Zhang, Qiong Zhou
Summary: Immunotherapy has advanced in lung cancer treatment, but many patients do not respond. Identifying novel targets is crucial in improving the response. Single-cell RNA sequencing enables the identification of cellular markers and understanding of their functions in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
David Dora, Christopher Rivard, Hui Yu, Shivaun Lueke Pickard, Viktoria Laszlo, Tunde Harko, Zsolt Megyesfalvi, Elek Dinya, Csongor Gerdan, Gabor Szegvari, Fred R. Hirsch, Balazs Dome, Zoltan Lohinai
Summary: This study aims to characterize the biomarkers of TAMs and MDSCs in limited-stage SCLC using RNAseq and IHC. The research identified differences in cell types and molecular pathways in the TME between NE-low and NE-high subtypes.
Article
Biochemistry & Molecular Biology
Guangxu Cao, Jiali Yue, Yetian Ruan, Ya Han, Yong Zhi, Jianqiao Lu, Min Liu, Xinxin Xu, Jin Wang, Quan Gu, Xuejun Wen, Jinli Gao, Qingfeng Zhang, Jiuhong Kang, Chenfei Wang, Fang Li
Summary: This study conducted single-cell RNA and TCR sequencing of cervical cancer tumors and adjacent normal tissues to map the immune landscape. The study revealed tumor-specific germinal center B cells associated with improved clinical outcomes and established a joint model of tumor and stromal cells to predict patients' prognosis. These findings provide information for future combinational immunotherapy.
Article
Immunology
Songang Wu, Xuewen Li, Fan Hong, Qiang Chen, Yingying Yu, Shuanghui Guo, Yuanyuan Xie, Naian Xiao, Xuwen Kong, Wei Mo, Zhanxiang Wang, Shaoxuan Chen, Feng Zeng
Summary: This study used machine learning-based method to integrate public scRNA-seq datasets and established a comprehensive atlas of immune cells infiltrating in cross-age GBM. The findings showed remarkable differences in immune cell compositions across ages, with a significant increase of extracranial monocyte-derived macrophages (MDMs) in senior patients, which contributes to worse prognosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ying Zhao, Qilin Zhang, Kailin Tu, Yanmei Chen, Yuxuan Peng, Yinyun Ni, Guonian Zhu, Cheng Cheng, Yangqian Li, Xue Xiao, Chunyan Yu, Keying Lu, Yaxin Chen, Chengpin Li, Jun Tang, Gang Wang, Wenxin Luo, Wengeng Zhang, Guowei Che, Weimin Li, Zhoufeng Wang, Dan Xie
Summary: This study identified three clusters of immune cells with immunosuppressive effects in the TME of NSCLC patients, providing insights into the heterogeneity of CD45(+) immune cells and potential genes involved in immune cell phenotypes. Understanding the TME is crucial for explaining NSCLC progression and its response to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Peng Qiu, Yutao Chen, Cheng Dong, Juanjuan Xie, Junwu Wang
Summary: This study analyzed scRNA-seq data of LUAD patients to identify DEGs associated with immune infiltration and survival time, and predicted transcriptional factors. The findings shed new light on the molecular mechanisms and potential individual therapy of LUAD.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Gastroenterology & Hepatology
Qing-yang Zhang, Daniel Wai-Hung Ho, Yu -Man Tsui, Irene Oi-Lin Ng
Summary: Hepatocellular carcinoma is known for its high levels of heterogeneity both within and between tumors, with recent advances in single-cell RNA sequencing providing crucial insights into its pathogenesis and tumor ecosystem. This technology allows for a detailed analysis of the various cell types and interactions within HCC, offering potential implications for personalized medicine in understanding tumor growth, progression, and treatment resistance.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang, Xing-Xing Fan
Summary: PKC delta is identified as a critical factor in the non-inflamed tumor microenvironment (TME) of EGFR-mutated lung cancer. Inhibition of PKC delta enhances the infiltration of immune cells into tumors and increases the sensitivity of tumors to immune checkpoint blockade therapy.
Article
Oncology
Jun Liu, Yaxin Ji, Xiaodan Weng, Wei Shao, Jiaping Zhao, Hanlin Chen, Lu Shen, Fufeng Wang, Qi Meng, Xue Wu, Xiaonan Wang, Qiuxiang Ou, Honggang Ke
Summary: This study investigated the differences in gene expression profiles and immune microenvironment in early-stage lung adenocarcinoma. It identified PTGFRN and SPP1 as potential prognostic markers and found enhanced antigen presentation ability during early-stage invasion. However, immune system tumor-killing ability was inhibited.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Longhui Li, Yangyueying Liang, Minghui Yu, Lu Zhao, Qingyun Mei, Yongchao Yu, Na Wang, Dou Zhang, Ziwei Wang, Yingjie Jia, Fanming Kong
Summary: Small cell lung cancer (SCLC) is one of the most aggressive neuroendocrine tumors with a disappointing prognosis. Although it initially responds well to chemotherapy, most patients experience recurrence and poor survival. The application of ICIs in SCLC is still necessary to explore since it broke the treatment deadlock.
Review
Oncology
Yijie Zhang, Dan Wang, Miao Peng, Le Tang, Jiawei Ouyang, Fang Xiong, Can Guo, Yanyan Tang, Yujuan Zhou, Qianjin Liao, Xu Wu, Hui Wang, Jianjun Yu, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Yixin Tan, Wei Xiong
Summary: Single-cell RNA sequencing is a crucial technology in tumor research, revealing tumor cell heterogeneity, monitoring tumor development, and aiding in the classification of immune cells and drug resistance mechanisms.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Xiaoyang Zhang, Zesheng Li, Cheng Wei, Lin Luo, Shenghui Li, Junhu Zhou, Hao Liang, Ying Li, Lei Han
Summary: In this study, the correlation between high expression of PLK4 and malignant progression of gliomas was demonstrated, and the possible involvement of PLK4 in regulating cell cycle, cell proliferation, and macrophage infiltration in gliomas was identified.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Jing Wen, Shuogui Fang, Yi Hu, Mian Xi, Zelin Weng, Chuqing Pan, Kongjia Luo, Yihong Ling, Renchun Lai, Xiuying Xie, Xiaodan Lin, Ting Lin, Jiyang Chen, Qianwen Liu, Jianhua Fu, Hong Yang
Summary: This study used single-cell RNA sequencing to examine the cellular and molecular dynamics in esophageal squamous cell carcinoma (ESCC) patients before and after neoadjuvant chemoradiotherapy (neoCRT). The findings revealed that neoCRT increased the infiltration of CD8(+) T cells in the tumor microenvironment but also promoted their exhaustion. Additionally, neoCRT influenced the differentiation and abundance of other immune cell types, including Th cells, Treg cells, cDC1s, and macrophages.
Review
Immunology
Rui Tang, Haitao Wang, Mingxi Tang
Summary: This review summarizes the characteristics, interactions, and roles of tissue-resident immune cells in non-small cell lung cancer (NSCLC) and their potential applications in immunotherapy. Tissue-resident immune cells have been found to play a significant role in NSCLC progression and response to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Chufeng Chen, Jiaying Liu, Yidong Chen, Anqi Lin, Weiming Mou, Lingxuan Zhu, Tao Yang, Quan Cheng, Jian Zhang, Peng Luo
Summary: Researches have shown that chronic viral infection and persistent exposure to antigens and/or inflammatory signals in cancer can lead to T cell exhaustion due to major changes in the epigenetic and metabolic environment. The discovery of the immune checkpoint pathway has been a significant milestone in understanding and reversing T cell exhaustion. Antibodies targeting these pathways have demonstrated superior capability in reversing T cell exhaustion. However, immune checkpoint blocking therapy still has limitations, such as short-term therapeutic effects and high individual heterogeneity. Assay for transposase-accessible chromatin with sequencing (ATAC-seq) is a method that can analyze the accessibility of whole-genome chromatin. Increasing studies have reported that ATAC-seq can characterize the dynamic changes of epigenetics in T cell exhaustion. It has been found that immune checkpoint blocking therapy can only temporarily restore the function of exhausted T cells due to irreversible changes in their epigenetics. In this study, we review the latest developments that provide a clearer molecular understanding of T cell exhaustion, reveal potential new therapeutic targets for persistent viral infection and cancer, and offer new insights for designing effective immunotherapy for cancer and chronic infection.
CANCER GENE THERAPY
(2023)
Article
Oncology
Zaoqu Liu, Hui Xu, Siyuan Weng, Chunguang Guo, Qin Dang, Yuyuan Zhang, Yuqing Ren, Long Liu, Libo Wang, Xiaoyong Ge, Zhe Xing, Jian Zhang, Peng Luo, Xinwei Han
Summary: A machine learning-based prognostic signature (MLPS) has been developed to predict the prognosis of melanoma patients, showing superior predictive performance compared to clinical traits and other collected signatures.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Editorial Material
Immunology
Clare Y. Slaney, Peng Luo, Feng-Ming Kong, Linlang Guo, Jian Zhang
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Nan Zhang, Hao Zhang, Zaoqu Liu, Ziyu Dai, Wantao Wu, Ran Zhou, Shuyu Li, Zeyu Wang, Xisong Liang, Jie Wen, Xun Zhang, Bo Zhang, Sirui Ouyang, Jian Zhang, Peng Luo, Xizhe Li, Quan Cheng
Summary: The study found that a model based on immune cells' specific genes could predict survival outcomes of lung adenocarcinoma patients. This model shows promise in predicting disease progression and treatment response, providing valuable information for clinical decision-making.
CELL PROLIFERATION
(2023)
Article
Immunology
Ziyu Dai, Nan Zhang, Ran Zhou, Hao Zhang, Liyang Zhang, Zeyu Wang, Wenjing Zeng, Peng Luo, Jian Zhang, Zhixiong Liu, Quan Cheng
Summary: This study constructed a novel gene pair signature based on relative expression order within the samples from bulk and single-cell sequencing. The signature showed solid ability to predict the prognosis of glioblastoma and pan-cancer, and distinguished samples with different malignant biological hallmarks. The high gene pair score group was associated with classic copy number variations, oncogenic mutations, and extensive hypomethylation, while the increased gene pair score group showed enrichment in tumor and immune-related signaling pathways, along with immunological diversity. The infiltration of M2 macrophages in the high gene pair score group suggests potential therapeutic options targeting adaptive and innate immunity. Overall, the gene pair signature provides valuable information for predicting prognosis and guiding clinical practice.
CLINICAL IMMUNOLOGY
(2023)
Letter
Oncology
Tianqi Gu, Anqi Lin, Haitao Wang, Jian Zhang, Peng Luo
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Zhifei Gao, Yifeng Bai, Anqi Lin, Aimin Jiang, Chaozheng Zhou, Quan Cheng, Zaoqu Liu, Xin Chen, Jian Zhang, Peng Luo
Summary: As a nontraditional T-cell subgroup, gamma delta T cells have shown great potential in immunotherapy for tumors. Immune checkpoint inhibitors (ICIs) have become pioneer drugs in tumor immunotherapy, and studies have shown that targeting ICs can reverse the dysfunctional state of gamma delta T cells in the tumor microenvironment and enhance their antitumor effects. Understanding the functional state of gamma delta T cells and their interaction with ICs will solidify ICIs combined with gamma delta T cells as a viable treatment option.
Article
Cardiac & Cardiovascular Systems
Chunrun Qu, Sheng Liao, Jingdan Zhang, Hui Cao, Hao Zhang, Nan Zhang, Luzhe Yan, Gaoyuan Cui, Peng Luo, Qingwei Zhang, Quan Cheng
Summary: This study reported the burden of cardiovascular disease (CVD) in elderly individuals over 70 from 1990 to 2019 based on the Global Burden of Disease Study 2019. The global CVD incidence, prevalence, death, and disability-adjusted life year rates generally decreased during this period, but the burden remains high. The rapid growth of burden in some regions of Africa and Asia is concerning. Furthermore, the burden tends to concentrate towards countries with a low socioeconomic index (SDI), indicating health inequality. The burden of CVD in older people remains severe and policymakers need to implement targeted measures to reduce its harm.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cell Biology
Yuyuan Zhang, Zaoqu Liu, Jie Li, Bailu Wu, Xin Li, Mengjie Duo, Hui Xu, Long Liu, Xiaoxing Su, Xuhua Duan, Peng Luo, Jian Zhang, Zhen Li
Summary: This study explored the relationships among pathway alterations in hepatocellular carcinoma (HCC) patients and identified pivotal pathways related to prognosis, sorafenib, and transcatheter arterial chemoembolization (TACE). The findings provide new insights for precision treatment and improving clinical outcomes in HCC.
CELLULAR SIGNALLING
(2023)
Article
Neurosciences
Wei-Wei Duan, Li-Ting Yang, Jian Liu, Zi-Yu Dai, Ze-Yu Wang, Hao Zhang, Xun Zhang, Xi-Song Liang, Peng Luo, Jian Zhang, Zao-Qu Liu, Nan Zhang, Hao-Yang Mo, Chun-Run Qu, Zhi-Wei Xia, Quan Cheng
Summary: In this study, a prognostic lncRNA signature related to TGF-beta signaling was established in glioma. The signature was proven to be a reliable prognostic tool and provided insights into immune infiltration characteristics and immunotherapy response prediction. Furthermore, AGAP2-AS1 was identified as an important player in glioma progression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Yushan Huang, Anqi Lin, Tianqi Gu, Shuang Hou, Jiarong Yao, Peng Luo, Jian Zhang
Summary: This study examined the relationship between mutation status and prognosis and the possible mechanisms. The results suggest CACNA1C mutation status is a potential biomarker for SKCM immunotherapy.
Article
Immunology
Suizi Zhou, Chaozheng Zhou, Xinyue Wang, Peng Luo, Anqi Lin, Yi Cui, Qianhui Qiu
Summary: Through gene expression analysis, it was found that immune cell infiltration increased in patients with seasonal allergic rhinitis (SAR), especially an increase in the proportion of CD8 positive T cells and a decrease in the proportion of neutrophils. Additionally, the NF-kappa B and Toll-like receptor signaling pathways were enriched in SAR patients. These findings suggest that T cell receptor signaling pathways and T helper 1/2 cell differentiation may play important roles in the development of SAR.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hao Zhang, Xinghai Yue, Zhe Chen, Chao Liu, Wantao Wu, Nan Zhang, Zaoqu Liu, Liping Yang, Qing Jiang, Quan Cheng, Peng Luo, Guodong Liu
Summary: This article summarizes the heterogeneity of cancer-associated fibroblasts (CAFs), including their origin, phenotype, and function. CAFs have various functions and sophisticated mechanisms in promoting cancer progression. The advancements in treatment strategies and clinical trials targeting CAFs are also highlighted.
Review
Biochemistry & Molecular Biology
Yuqing Ren, Ruizhi Wang, Siyuan Weng, Hui Xu, Yuyuan Zhang, Shuang Chen, Shutong Liu, Yuhao Ba, Zhaokai Zhou, Peng Luo, Quan Cheng, Qin Dang, Zaoqu Liu, Xinwei Han
Summary: The disruption of redox homeostasis has negative effects on cancer development, which is closely linked to various redox processes. This study aims to investigate the impact of multi-source reactive oxygen species (ROS) on apoptosis, autophagy, and anti-tumor immune response in the tumor microenvironment, as well as the mutual crosstalk between these processes. It also examines the relationship between traditional cancer therapy and ROS, and discusses potential ROS-related treatment options for future studies.
Article
Public, Environmental & Occupational Health
Shulu Hu, Anqi Lin, Peng Luo, Jian Zhang
Summary: The rate of cannabis use is increasing among cancer patients. This study analyzed data from 2005 to 2018 and found a significant positive correlation between cannabis use and depression in cancer patients, especially among female patients, those with a history of cocaine use, and those who started using cannabis after the age of 17.
PREVENTIVE MEDICINE REPORTS
(2023)