Osteopontin Blockade Immunotherapy Increases Cytotoxic T Lymphocyte Lytic Activity and Suppresses Colon Tumor Progression

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

(2020) Lei Zhang et al.   CELL

Osteopontin: A Key Regulator of Tumor Progression and Immunomodulation

(2020) Hannah R. Moorman et al.   Cancers

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

SUV39H1 represses the expression of cytotoxic T-lymphocyte effector genes to promote colon tumor immune evasion

(2019) Chunwan Lu et al.   Cancer Immunology Research

Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade

(2019) Ying Zhu et al.   GUT

Follistatin-like Protein 1 Inhibits Lung Cancer Metastasis by Preventing Proteolytic Activation of Osteopontin

(2019) Jean Chiou et al.   CANCER RESEARCH

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

(2018) Elham Azizi et al.   CELL

Assessing the Feasibility of Neutralizing Osteopontin with Various Therapeutic Antibody Modalities

(2018) Vahid Farrokhi et al.   Scientific Reports

Osteopontin controls immunosuppression in the tumor microenvironment

(2018) Michael R. Shurin   JOURNAL OF CLINICAL INVESTIGATION

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

(2018) John D. Klement et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

(2018) Jun Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulation of PD-L1 by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma

(2017) Yan Zhang et al.   EXPERIMENTAL CELL RESEARCH

The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors

(2017) Laetitia Marisa et al.   JNCI-Journal of the National Cancer Institute

Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival

(2017) Bernhard Mlecnik et al.   JNCI-Journal of the National Cancer Institute

The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors

(2017) Laetitia Marisa et al.   JNCI-Journal of the National Cancer Institute

Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival

(2017) Bernhard Mlecnik et al.   JNCI-Journal of the National Cancer Institute

Tumour CD274 (PD-L1) expression and T cells in colorectal cancer

(2016) Yohei Masugi et al.   GUT

Osteopontin-Expressing Macrophages in Non-Small Cell Lung Cancer Predict Survival

(2015) Yue Li et al.   ANNALS OF THORACIC SURGERY

The significance of the co-existence of osteopontin and tumor-associated macrophages in gastric cancer progression

(2015) Chang-Ni Lin et al.   BMC CANCER

Tumor-Derived Osteopontin Reprograms Normal Mammary Fibroblasts to Promote Inflammation and Tumor Growth in Breast Cancer

(2015) Y. Sharon et al.   CANCER RESEARCH

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia

(2015) Naoyoshi Maeda et al.   Retrovirology

The ins and outs of osteopontin

(2015) Claudia Chiodoni et al.   OncoImmunology

Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis

(2014) Bo Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor-Derived Osteopontin Suppresses Antitumor Immunity by Promoting Extramedullary Myelopoiesis

(2014) E.-K. Kim et al.   CANCER RESEARCH

Osteopontin Shapes Immunosuppression in the Metastatic Niche

(2014) Sabina Sangaletti et al.   CANCER RESEARCH

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints

(2014) Nicolas J. Llosa et al.   Cancer Discovery

Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via α9β1 integrin

(2013) S Kale et al.   ONCOGENE

Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer

(2012) G. Rao et al.   CLINICAL CANCER RESEARCH

Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer

(2012) Farbod Shojaei et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Osteopontin-Enhanced Hepatic Metastasis of Colorectal Cancer Cells

(2012) Jianjin Huang et al.   PLoS One

Prognostic Significance of Plasma Osteopontin in Patients with Locoregionally Advanced Head and Neck Squamous Cell Carcinoma Treated on TROG 02.02 Phase III Trial

(2011) A. M. Lim et al.   CLINICAL CANCER RESEARCH

Identification of osteopontin as a novel marker for early hepatocellular carcinoma

(2011) Sufen Shang et al.   HEPATOLOGY

Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease

(2010) F. Zhao et al.   BLOOD

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

(2010) Mary Zimmerman et al.   Jove-Journal of Visualized Experiments

Coordination of Intratumoral Immune Reaction and Human Colorectal Cancer Recurrence

(2009) M. Camus et al.   CANCER RESEARCH

Gene Expression Profiling of Paraffin-Embedded Primary Melanoma Using the DASL Assay Identifies Increased Osteopontin Expression as Predictive of Reduced Relapse-Free Survival

(2009) C. Conway et al.   CLINICAL CANCER RESEARCH

Treatment of collagen‐induced arthritis with an anti‐osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells

(2008) Kexing Fan et al.   ARTHRITIS AND RHEUMATISM

Osteopontin Promotes Vascular Endothelial Growth Factor Dependent Breast Tumor Growth and Angiogenesis via Autocrine and Paracrine Mechanisms

(2008) G. Chakraborty et al.   CANCER RESEARCH

Osteopontin regulates development and function of invariant natural killer T cells

(2008) H. Diao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA