Age-Related Expression of IFN-λ1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected Individuals

Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation

(2021) Cecile King et al.   TRENDS IN IMMUNOLOGY

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial

(2021) Jordan J Feld et al.   Lancet Respiratory Medicine

Downregulation of type III interferons in patients with severe COVID‐19

(2021) Yosuke Fukuda et al.   JOURNAL OF MEDICAL VIROLOGY

Functional landscape of SARS-CoV-2 cellular restriction

(2021) Laura Martin-Sancho et al.   MOLECULAR CELL

RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

(2021) Taisho Yamada et al.   NATURE IMMUNOLOGY

Human Surfactant Protein D Binds Spike Protein and Acts as an Entry Inhibitor of SARS-CoV-2 Pseudotyped Viral Particles

(2021) Miao-Hsi Hsieh et al.   Frontiers in Immunology

The interferon landscape along the respiratory tract impacts the severity of COVID-19

(2021) Benedetta Sposito et al.   CELL

IFN-λ1 Displays Various Levels of Antiviral Activity In Vitro in a Select Panel of RNA Viruses

(2021) Marina Plotnikova et al.   Viruses-Basel

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

(2020) Hin Chu et al.   CLINICAL INFECTIOUS DISEASES

Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2

(2020) Cheng Wang et al.   GASTROENTEROLOGY

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

COVID-19 and emerging viral infections: The case for interferon lambda

(2020) Ludmila Prokunina-Olsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents

(2020) Riccardo Castagnoli et al.   JAMA Pediatrics

Inhibition of SARS-CoV-2 by type I and type III interferons

(2020) Ulrike Felgenhauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

(2020) Megan L. Stanifer et al.   Cell Reports

Interplay between SARS-CoV-2 and the type I interferon response

(2020) Margarida Sa Ribero et al.   PLoS Pathogens

The Dichotomous Responses Driven by β-Defensins

(2020) Jennifer R. Shelley et al.   Frontiers in Immunology

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

(2020) Kenneth H. Dinnon et al.   NATURE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2

(2020) Idoia Busnadiego et al.   mBio

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

(2020) Hanjun Zhao et al.   Nature Communications

SARS-CoV-2 Infection Boosts MX1 Antiviral Effector in COVID-19 Patients

(2020) Juan Bizzotto et al.   iScience

Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

(2020) Petra Zimmermann et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Host genetic susceptibility to viral infections: the role of type I interferon induction

(2020) Marie Bourdon et al.   GENES AND IMMUNITY

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

(2020) Ruochen Zang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

(2020) Robbert Boudewijns et al.   Nature Communications

Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms

(2019) Stefan Bidula et al.   Journal of Immunology Research

Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

Interferon Lambda's New Role as Regulator of Neutrophil Function

(2019) Amariliz Rivera   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

(2019) Rudragouda Channappanavar et al.   JOURNAL OF CLINICAL INVESTIGATION

Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus

(2019) Emily A. Hemann et al.   NATURE IMMUNOLOGY

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons

(2019) Adriana Forero et al.   IMMUNITY

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion

(2019) Achille Broggi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

(2018) Jonas Klinkhammer et al.   eLife

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

(2018) Kalliopi Pervolaraki et al.   PLoS Pathogens

Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

(2017) Ioanna E. Galani et al.   IMMUNITY

Defensins in Viral Infection and Pathogenesis

(2017) Mayumi K. Holly et al.   Annual Review of Virology

Mx GTPases: dynamin-like antiviral machines of innate immunity

(2015) Otto Haller et al.   TRENDS IN MICROBIOLOGY

Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?

(2015) Suan-Sin Foo et al.   TRENDS IN MICROBIOLOGY

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

IFITM Proteins Inhibit Entry Driven by the MERS-Coronavirus Spike Protein: Evidence for Cholesterol-Independent Mechanisms

(2014) Florian Wrensch et al.   Viruses-Basel

Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression

(2013) Christopher R. Bolen et al.   HEPATOLOGY

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

(2012) Tobias R. Kollmann et al.   IMMUNITY

Molecular Signatures Associated with Mx1-Mediated Resistance to Highly Pathogenic Influenza Virus Infection: Mechanisms of Survival

(2011) C. Cilloniz et al.   JOURNAL OF VIROLOGY

Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells

(2011) Tamaki Okabayashi et al.   VIRUS RESEARCH

Induction and function of type I and III interferon in response to viral infection

(2011) David E Levy et al.   Current Opinion in Virology

Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus

(2011) I-Chueh Huang et al.   PLoS Pathogens

Dysregulation of human Toll-like receptor function in aging

(2010) Albert C. Shaw et al.   AGEING RESEARCH REVIEWS

Defensins in Viral Infections

(2009) Jian Ding et al.   Journal of Innate Immunity

Dysregulation of TLR3 Impairs the Innate Immune Response to West Nile Virus in the Elderly

(2008) K.-F. Kong et al.   JOURNAL OF VIROLOGY