STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
Authors
Keywords
-
Journal
Nature Communications
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-11-17
DOI
10.1038/s41467-020-19684-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China
- (2020) Dawei Wang et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Reducing mortality from 2019-nCoV: host-directed therapies should be an option
- (2020) Alimuddin Zumla et al. LANCET
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- (2020) Chaolin Huang et al. LANCET
- Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study
- (2020) Heshui Shi et al. LANCET INFECTIOUS DISEASES
- A Novel Coronavirus from Patients with Pneumonia in China, 2019
- (2020) Na Zhu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases
- (2020) Tao Ai et al. RADIOLOGY
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
- (2020) Daniel Wrapp et al. SCIENCE
- Accounting for population structure reveals ambiguity in the Zaire Ebolavirus reservoir dynamics
- (2020) Bram Vrancken et al. PLoS Neglected Tropical Diseases
- Pathological findings of COVID-19 associated with acute respiratory distress syndrome
- (2020) Zhe Xu et al. Lancet Respiratory Medicine
- Tocilizumab therapy in five solid and composite tissue transplant recipients with early ARDS due to SARS‐CoV‐2
- (2020) Jose A. Morillas et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2
- (2020) Ren-Di Jiang et al. CELL
- SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
- (2020) Carly G.K. Ziegler et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- A Mouse Model of SARS-CoV-2 Infection and Pathogenesis
- (2020) Shi-Hui Sun et al. Cell Host & Microbe
- Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility
- (2020) Jasper Fuk-Woo Chan et al. CLINICAL INFECTIOUS DISEASES
- Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection
- (2020) Lu Lin et al. GUT
- Clinical progression of patients with COVID-19 in Shanghai, China
- (2020) Jun Chen et al. JOURNAL OF INFECTION
- Pathogenesis and transmission of SARS-CoV-2 in golden hamsters
- (2020) Sin Fun Sia et al. NATURE
- The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
- (2020) Linlin Bao et al. NATURE
- The proximal origin of SARS-CoV-2
- (2020) Kristian G. Andersen et al. NATURE MEDICINE
- Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
- (2020) Barry Rockx et al. SCIENCE
- Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study
- (2020) Tao Chen et al. BMJ-British Medical Journal
- Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients
- (2020) Jing Liu et al. EBioMedicine
- Combined IL‐6 and JAK/STAT inhibition therapy in COVID‐19‐related sHLH, potential game changer
- (2020) Sophie Portsmore et al. BRITISH JOURNAL OF HAEMATOLOGY
- Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies
- (2020) Daniel Wrapp et al. CELL
- A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies
- (2020) Ahmed O. Hassan et al. CELL
- Compassionate Use of Tocilizumab for Treatment of SARS-CoV-2 Pneumonia
- (2020) Stanley C Jordan et al. CLINICAL INFECTIOUS DISEASES
- The potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19
- (2020) Bakiye Goker Bagca et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Immune status could determine efficacy of COVID-19 therapies
- (2020) Megan Cully NATURE REVIEWS DRUG DISCOVERY
- Type I and III interferons disrupt lung epithelial repair during recovery from viral infection
- (2020) Jack Major et al. SCIENCE
- Type III interferons disrupt the lung epithelial barrier upon viral recognition
- (2020) Achille Broggi et al. SCIENCE
- Spatial Comparisons of Mechanosensory Information Govern the Grooming Sequence in Drosophila
- (2020) Neil Zhang et al. CURRENT BIOLOGY
- Consensus transcriptional regulatory networks of coronavirus-infected human cells
- (2020) Scott A. Ochsner et al. Scientific Data
- New treatment options for delta virus: Is a cure in sight?
- (2019) Cihan Yurdaydin JOURNAL OF VIRAL HEPATITIS
- Targeting Interleukin-6 Signaling in Clinic
- (2019) Sujin Kang et al. IMMUNITY
- Interferon-Stimulated Genes: What Do They All Do?
- (2019) John W. Schoggins Annual Review of Virology
- An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans
- (2019) Murilo Delgobo et al. eLife
- Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
- (2018) Maria L. Agostini et al. mBio
- A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients
- (2018) Ricardo Khouri et al. OncoImmunology
- Origin and evolution of pathogenic coronaviruses
- (2018) Jie Cui et al. NATURE REVIEWS MICROBIOLOGY
- Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control
- (2018) Evangelos Andreakos et al. CURRENT OPINION IN IMMUNOLOGY
- Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology
- (2017) Rudragouda Channappanavar et al. Seminars in Immunopathology
- Zika virus infection of adult and fetal STAT2 knock-out hamsters
- (2017) Venkatraman Siddharthan et al. VIROLOGY
- Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice
- (2016) Rudragouda Channappanavar et al. Cell Host & Microbe
- Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir
- (2016) Brian B. Gowen et al. JOURNAL OF VIROLOGY
- Longitudinal, in vivo assessment of invasive pulmonary aspergillosis in mice by computed tomography and magnetic resonance imaging
- (2016) Jennifer Poelmans et al. LABORATORY INVESTIGATION
- The cytokine storm of severe influenza and development of immunomodulatory therapy
- (2015) Qiang Liu et al. Cellular & Molecular Immunology
- Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume
- (2015) Greetje Vande Velde et al. Disease Models & Mechanisms
- Modular approach to customise sample preparation procedures for viral metagenomics: a reproducible protocol for virome analysis
- (2015) Nádia Conceição-Neto et al. Scientific Reports
- STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control
- (2015) Karoly Toth et al. PLoS Pathogens
- Inhibitors of the Interferon Response Enhance Virus Replication In Vitro
- (2014) Claire E. Stewart et al. PLoS One
- Efficient Gene Targeting in Golden Syrian Hamsters by the CRISPR/Cas9 System
- (2014) Zhiqiang Fan et al. PLoS One
- Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes
- (2013) Jacqueline K. White et al. CELL
- Iterative CT Reconstruction Using Shearlet-Based Regularization
- (2013) Bert Vandeghinste et al. IEEE TRANSACTIONS ON NUCLEAR SCIENCE
- Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling
- (2012) Daniel J. Gough et al. IMMUNITY
- Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread
- (2012) T. Mahlakoiv et al. JOURNAL OF GENERAL VIROLOGY
- Induction of Alternatively Activated Macrophages Enhances Pathogenesis during Severe Acute Respiratory Syndrome Coronavirus Infection
- (2012) C. Page et al. JOURNAL OF VIROLOGY
- Quantification of Lung Fibrosis and Emphysema in Mice Using Automated Micro-Computed Tomography
- (2012) Ellen De Langhe et al. PLoS One
- Validation of assays to monitor immune responses in the Syrian golden hamster (Mesocricetus auratus)
- (2011) Marko Zivcec et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections
- (2010) M. Mordstein et al. JOURNAL OF VIROLOGY
- SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism
- (2010) Matthew B. Frieman et al. PLoS Pathogens
- Neutralizing antibody against severe acute respiratory syndrome (SARS)-coronavirus spike is highly effective for the protection of mice in the murine SARS model
- (2008) Koji Ishii et al. MICROBIOLOGY AND IMMUNOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started