Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

(2020) Jasper Fuk-Woo Chan et al.   Emerging Microbes & Infections

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

(2020) Annsea Park et al.   Cell Host & Microbe

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

(2020) Hin Chu et al.   CLINICAL INFECTIOUS DISEASES

A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia

(2020) Isabella Quinti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Cytokine release syndrome in severe COVID-19

(2020) John B. Moore et al.   SCIENCE

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

(2020) Jing Liu et al.   EBioMedicine

Type 1 interferons as a potential treatment against COVID-19

(2020) Erwan Sallard et al.   ANTIVIRAL RESEARCH

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients

(2020) Christoph Kreer et al.   CELL

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

(2020) Víctor J. Costela-Ruiz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Lessons for COVID-19 Immunity from Other Coronavirus Infections

(2020) Alan Sariol et al.   IMMUNITY

Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

(2020) Emilie Seydoux et al.   IMMUNITY

Combination of four clinical indicators predicts the severe/critical symptom of patients infected COVID-19

(2020) Liping Sun et al.   JOURNAL OF CLINICAL VIROLOGY

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

(2020) Davide F. Robbiani et al.   NATURE

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

(2020) Quan-Xin Long et al.   NATURE MEDICINE

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

(2020) Jennifer A. Juno et al.   NATURE MEDICINE

Predictors of COVID ‐19 severity: A literature review

(2020) Benjamin Gallo Marin et al.   REVIEWS IN MEDICAL VIROLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Type III interferons disrupt the lung epithelial barrier upon viral recognition

(2020) Achille Broggi et al.   SCIENCE

Interplay between SARS-CoV-2 and the type I interferon response

(2020) Margarida Sa Ribero et al.   PLoS Pathogens

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

(2020) Naoki Kaneko et al.   CELL

SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates

(2020) Gregory A Poland et al.   LANCET

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

(2020) Yanchun Peng et al.   NATURE IMMUNOLOGY

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

(2020) Jin-Yan Li et al.   VIRUS RESEARCH

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

(2020) Yoriyuki Konno et al.   Cell Reports

Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production

(2020) Yuezhou Chen et al.   CELL

Emergence of a new SARS-CoV-2 variant in the UK

(2020) Julian W Tang et al.   JOURNAL OF INFECTION

Public needs to prep for vaccine side effects

(2020) Meredith Wadman   SCIENCE

The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

(2020) Lien Van Hoecke et al.   Molecular Therapy-Nucleic Acids

The Role of Interleukin 6 During Viral Infections

(2019) Lauro Velazquez-Salinas et al.   Frontiers in Microbiology

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

(2019) Rudragouda Channappanavar et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice

(2019) Jonna B. Westover et al.   Pathogens

Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes

(2017) Claudia Loetsch et al.   Cell Reports

Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly

(2017) Anshu Agrawal et al.   Frontiers in Immunology

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

(2016) Jincun Zhao et al.   IMMUNITY

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

IFN-  Exerts Opposing Effects on T Cell Responses Depending on the Chronicity of the Virus Infection

(2014) I. Misumi et al.   JOURNAL OF IMMUNOLOGY

Depletion of Alveolar Macrophages Ameliorates Virus-Induced Disease following a Pulmonary Coronavirus Infection

(2014) Stacey M. Hartwig et al.   PLoS One

Mechanisms and Implications of Age-Associated Impaired Innate Interferon Secretion by Dendritic Cells: A Mini-Review

(2013) Anshu Agrawal   GERONTOLOGY

Endothelial TNF Receptor 2 Induces IRF1 Transcription Factor-Dependent Interferon-β Autocrine Signaling to Promote Monocyte Recruitment

(2013) Deepak Venkatesh et al.   IMMUNITY

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

Intranasal Treatment with Poly(I{middle dot}C) Protects Aged Mice from Lethal Respiratory Virus Infections

(2012) J. Zhao et al.   JOURNAL OF VIROLOGY

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

(2012) Yun-Hee Youm et al.   Cell Reports

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

(2011) Jincun Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Lack of Peripheral Memory B Cell Responses in Recovered Patients with Severe Acute Respiratory Syndrome: A Six-Year Follow-Up Study

(2011) F. Tang et al.   JOURNAL OF IMMUNOLOGY

Impaired Interferon Signaling in Dendritic Cells From Older Donors Infected In Vitro With West Nile Virus

(2011) Feng Qian et al.   JOURNAL OF INFECTIOUS DISEASES

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

Emerging cellular networks for regulation of T follicular helper cells

(2011) Cecile King et al.   TRENDS IN IMMUNOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits

(2010) LuLu Gao et al.   VACCINE

Type I Interferon Signaling in Dendritic Cells Stimulates the Development of Lymph-Node-Resident T Follicular Helper Cells

(2009) Helena Cucak et al.   IMMUNITY

Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected Mice

(2009) Jincun Zhao et al.   PLoS Pathogens

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY