Siglecs Modulate Activities of Immune Cells Through Positive and Negative Regulation of ROS Generation

The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans

(2021) Benjamin A. H. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Modulation of immune cell reactivity with cis-binding Siglec agonists

(2021) Corleone S. Delaveris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay Between Sialic Acids, Siglec-E, and Neu1 Regulates MyD88- and TRIF-Dependent Pathways for TLR4-Activation During Leishmania donovani Infection

(2021) Joyshree Karmakar et al.   Frontiers in Immunology

Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19

(2021) Corleone S. Delaveris et al.   ACS Central Science

Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments

(2021) Elena Gianchecchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Siglec Ligands

(2021) Anabel Gonzalez-Gil et al.   Cells

Siglecs as Immune Cell Checkpoints in Disease

(2020) Shiteng Duan et al.   Annual Review of Immunology

Sialic Acid-Siglec-E Interactions During Pseudomonas aeruginosa Infection of Macrophages Interferes With Phagosome Maturation by Altering Intracellular Calcium Concentrations

(2020) Kaustuv Mukherjee et al.   Frontiers in Immunology

Discovery of a new sialic acid binding region that regulates Siglec-7

(2020) Nao Yamakawa et al.   Scientific Reports

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Targeted glycan degradation potentiates the anticancer immune response in vivo

(2020) Melissa A. Gray et al.   Nature Chemical Biology

Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy

(2020) Alain R. Thierry et al.   Journal of Clinical Medicine

Selective Response to Bacterial Infection by Regulating Siglec-E Expression

(2020) Yin Wu et al.   iScience

Current Status on Therapeutic Molecules Targeting Siglec Receptors

(2020) María Pia Lenza et al.   Cells

Oxidative Stress in Microbial Diseases: Pathogen, Host, and Therapeutics

(2019) Rômulo Dias Novaes et al.   Oxidative Medicine and Cellular Longevity

Nanoparticles Equipped with α2,8-Linked Sialic Acid Chains Inhibit the Release of Neutrophil Extracellular Traps

(2019) Bornhöfft et al.   Nanomaterials

Sialic acid–binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses

(2019) Heinz Läubli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Decreased erythrocyte binding of Siglec-9 increases neutrophil activation in sickle cell disease

(2019) Zachary M. Kiser et al.   BLOOD CELLS MOLECULES AND DISEASES

Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase‐derived reactive oxygen species in aging

(2019) Naazneen Khan et al.   FASEB JOURNAL

Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers

(2019) Chia-Hsueh Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses

(2019) Daniel Perez-Zsolt et al.   Viruses-Basel

Siglecs: A journey through the evolution of sialic acid-binding immunoglobulin-type lectins

(2018) Kim F. Bornhöfft et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Sialic acid–binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β 2 -integrin–dependent function in human eosinophils

(2018) Daniela J. Carroll et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mapping the interaction site and effect of the Siglec-9 inflammatory biomarker on human primary amine oxidase

(2018) Leonor Lopes de Carvalho et al.   Scientific Reports

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

(2018) Michal A. Stanczak et al.   JOURNAL OF CLINICAL INVESTIGATION

CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity

(2018) Edward A. Clark et al.   Frontiers in Immunology

Targeting reactive oxygen species for respiratory infection: Fact or fancy?

(2018) Stavros Selemidis   RESPIROLOGY

Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions

(2018) Joyce Lübbers et al.   Frontiers in Immunology

Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases

(2017) Gen Kano et al.   IMMUNOBIOLOGY

Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract

(2017) Kathryn A Patras et al.   IMMUNOLOGY AND CELL BIOLOGY

Increased expression of Siglec-9 in chronic obstructive pulmonary disease

(2017) Zhilin Zeng et al.   Scientific Reports

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

(2016) Marcus Karlstetter et al.   EMBO Molecular Medicine

Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infection

(2016) Eric Henrique Roma et al.   Parasites & Vectors

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

(2016) Maurizio Perdicchio et al.   Oncotarget

Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm

(2016) Saptarshi Roy et al.   PLoS Neglected Tropical Diseases

Multivalent Interactions of Human Primary Amine Oxidase with the V and C22 Domains of Sialic Acid-Binding Immunoglobulin-Like Lectin-9 Regulate Its Binding and Amine Oxidase Activity

(2016) Heli Elovaara et al.   PLoS One

Phagocyte NADPH oxidase and specific immunity

(2015) Julien Cachat et al.   CLINICAL SCIENCE

Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling

(2015) F. Gasparrini et al.   EMBO JOURNAL

Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation

(2015) Ismael Secundino et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Siglec receptors impact mammalian lifespan by modulating oxidative stress

(2015) Flavio Schwarz et al.   eLife

Discovery of Multifold Modified Sialosides as Human CD22/Siglec-2 Ligands with Nanomolar Activity on B-Cells

(2014) Horst Prescher et al.   ACS Chemical Biology

Siglec-E Promotes β2-Integrin-dependent NADPH Oxidase Activation to Suppress Neutrophil Recruitment to the Lung

(2014) Sarah J. McMillan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialylation of Outer Membrane Porin Protein D: A Mechanistic Basis of Antibiotic Uptake inPseudomonas aeruginosa

(2014) Biswajit Khatua et al.   MOLECULAR & CELLULAR PROTEOMICS

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

(2014) Heinz Läubli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo

(2014) Yung-Chi Chang et al.   PLoS Pathogens

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Mechanism of Siglec-8–mediated cell death in IL-5–activated eosinophils: Role for reactive oxygen species–enhanced MEK/ERK activation

(2013) Gen Kano et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microglial CD33-Related Siglec-E Inhibits Neurotoxicity by Preventing the Phagocytosis-Associated Oxidative Burst

(2013) J. Claude et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of Siglec-F-Induced Eosinophil Apoptosis: A Role for Caspases but Not for SHP-1, Src Kinases, NADPH Oxidase or Reactive Oxygen

(2013) Hui Mao et al.   PLoS One

Targeting of CD22-positive B-cell lymphoma cells by synthetic divalent sialic acid analogues

(2012) Astrid Schweizer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Siglec-8 and Siglec-F, the new therapeutic targets in asthma

(2012) Sima Sh. Farid et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer

(2011) K. Aalto et al.   BLOOD

IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils

(2011) Ho Jeong Na et al.   CYTOKINE

The Pan-B Cell Marker CD22 Is Expressed on Gastrointestinal Eosinophils and Negatively Regulates Tissue Eosinophilia

(2011) T. Wen et al.   JOURNAL OF IMMUNOLOGY

Basic and Clinical Immunology of Siglecs

(2009) Stephan von Gunten et al.   Annals of the New York Academy of Sciences

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Sialic acids acquired byPseudomonas aeruginosaare involved in reduced complement deposition and siglec mediated host-cell recognition

(2009) Biswajit Khatua et al.   FEBS LETTERS

Group BStreptococcussuppression of phagocyte functions by protein-mediated engagement of human Siglec-5

(2009) Aaron F. Carlin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Siglecs as targets for therapy in immune-cell-mediated disease

(2009) Mary K. O’Reilly et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY

Interleukin-5 Priming of Human Eosinophils Alters Siglec-8–Mediated Apoptosis Pathways

(2007) Esra Nutku-Bilir et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The function of the NADPH oxidase of phagocytes and its relationship to other NOXs in plants, invertebrates, and mammals

(2007) Anthony W. Segal   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY